Results 191 to 200 of about 48,872 (218)

[32] Interferon induction by polynucleotides, modified polynucleotides, and polycarboxylates

1981
Publisher Summary This chapter discusses the procedures for obtaining high interferon yields in primary rabbit kidney (PRK) and human fibroblasts (HF) cells, in response to (I) n . (C) n . The chapter discusses several procedures that are developed to enhance the interferon response of PRK and HF cell cultures to (I) n . (C) n .
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Methylation in the Study of Polynucleotides

Nature, 1949
ALTHOUGH detailed knowledge of the components of pentose nucleic acids is still incomplete, considerable effort over a long period has been directed towards the problem of the mode of union of the constituent nucleosides. It was early recognized that these units are linked through phosphoric acid residues, and the precise manner in which this takes ...
Kathleen R. Farrar, A. S. Anderson, G. R. Barker   +2 more
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Nucleic acids and polynucleotides

Journal of Cellular Physiology, 1969
The conformation of native double helical DNA is well-known, but it is possible that small regions occur within native DNA, undetectable by X-ray diffraction methods, which have different conformations. Model structures are the synthetic deoxypolynucleotides of defined sequence. Under the conditions used, DNA, poly d(A-T) • poly d(A-T), and poly d(T-G)
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Enzymic synthesis of polynucleotides I. polynucleotide phosphorylase of Azotobacter vinelandii

Biochimica et Biophysica Acta, 1956
The isolation, partial purification and some properties of polynucleotide phosphorylase of Azotobacter vinelandii are described. The enzyme catalyzes the synthesis of highly polymerized ribonucleic acid-like polynucleotides from 5′-nucleoside diphosphates with release of orthophosphate. The reaction requires magnesium ions and is reversible.
Marianne Grunberg-Manago, Severo Ochoa, Priscilla J. Ortiz   +2 more
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Hypochromicity of oligo- and polynucleotides

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1962
Abstract 1. 1. Syntheses of dinucleoside phosphates containing 6-dimethylaminopurine are described. The ultraviolet-absorption properties of these compounds show that hydrogen bonding is not a direct cause of hypochromicity. 2. The properties of chemically synthesised oligoguanylic acids and of dinucleoside 5′-pyrophosphates are examined and the ...
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On the Theories of Hypochromism in Polynucleotides

Radiation Research, 1963
Conformational changes and resulting effects on spectra involve intramolecular attractions between relatively independent groups such as the bases in polynucleotides. Intramolecular forces (4) and additivity of group properties (1) in polymers are discussed in general by assuming the total wave function of a polymer to be the product of independent ...
Oktay Sinanoğlu, Oktay Sinanoglu
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The Synthesis of Polynucleotides

1979
Publisher Summary This chapter focuses on the chemical synthesis of oligo and poly-nucleotides. Some of the ways in which synthetic polynucleotides have been used in clarifying molecular-biological problems, and comments on areas in which such compounds are currently under investigation are summarized in the chapter.
Morio Ikehara, Eiko Ohtsuka, Alexander F. Markham   +2 more
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Mechanism of polynucleotide phosphorylase

Biochemistry, 1989
The de novo polymerization of RNA initiated by polynucleotide phosphorylase from nucleoside diphosphates was examined. End group analysis performed under conditions designed to specifically end label the polymer revealed no evidence for a 5'-pyrophosphate-terminated polymer.
Silvio P. Marchese-Ragona, Michael A. Sulewski, Stephen J. Benkovic, Kenneth A. Johnson   +3 more
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The Polynucleotide Field

Nature, 1961
Polynucleotides Natural and Synthetic Nucleic Acids. By Robert F. Steiner, and Roland F. Beers Jr. Pp. viii + 404. (Amsterdam: Elsevier Publishing Company; London: D. Van Nostrand Company, Ltd., 1961.) 85s.
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The hypochromism of helical polynucleotides

Journal of Molecular Biology, 1962
The hypochromism of the 260 mμ. absorption band of helical DNA is its lower absorbance, per base group, compared to the absorbance of the mononucleotides. The hypochromism of DNA has been calculated as a function pf the base composition and sequence. The oscillator strengths, transition monopoles and transition moments for the π→π* transitions of the ...
Howard DeVoe, Ignacio Tinoco
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