Results 251 to 260 of about 93,488 (303)

Biologic Properties of Polynucleotides. II. The Anticoagulant Properties of Polynucleotides

Blood, 1964
Abstract Polyinosinic and polyguanylic acids have been found to possess anticoagulant properties. Other synthetic homoribopolynucleotides, as well as naturally occurring RNAs and DNAs are devoid of such properties. Polyinosinic acid will prolong the silicone recalcification time, Quick one-stage prothrombin time, and Russel Viper Venom ...
Stanley Yachnin, Stanley Yachnin
openaire   +3 more sources

Plasmonic AuNP/g-C3N4 Nanohybrid-based Photoelectrochemical Sensing Platform for Ultrasensitive Monitoring of Polynucleotide Kinase Activity Accompanying DNAzyme-Catalyzed Precipitation Amplification.

ACS Applied Materials and Interfaces, 2015
A convenient and feasible photoelectrochemical (PEC) sensing platform based on gold nanoparticles-decorated g-C3N4 nanosheets (AuNP/g-C3N4) was designed for highly sensitive monitoring of T4 polynucleotide kinase (PNK) activity, using DNAzyme-mediated ...
Junyang Zhuang, Wenqiang Lai, Mingdi Xu, Qian Zhou, D. Tang   +4 more
semanticscholar   +1 more source

Polarography of polynucleotides

Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1979
Abstract It has been shown that the thermally labile double-stranded polyribonucleotides poly(adenylic acid) · poly(uridylic acid) and poly(cytidylic acid) · poly(inosinic acid) produce differential pulse polarographic (DPP) peaks analogous to the DPP peak II of double-stranded deoxyribonucleic acid.
Emil Paleček, František Jelen
openaire   +2 more sources

Synthetic Analogues of Polynucleotides

Nature, 1968
ANALOGUES of purines and pyrimidines have been used as antimetabolites1. Some of these have been converted into their nucleosides or nucleotides which also act as antimetabolites2. Analogues of nucleosides in which D-ribose or 2-deoxy-D-ribose is replaced by another carbohydrate or carbohydrate analogue have also been extensively studied2.
A. S. Jones, M. H. Halford
openaire   +3 more sources

Biomaterials for polynucleotide delivery to anchorage-independent cells.

Journal of materials chemistry. B, 2017
Anchorage-independent cells possess morphological features and cell membrane compositions that are distinct from adherent cells. They display minimal surface area, have a low rate of endocytosis and generally possess few proteoglycans which make it a ...
Aysha S Ansari, P. Santerre, H. Uludaǧ
semanticscholar   +1 more source

Studies on polynucleotides

Journal of Molecular Biology, 1965
A ribopolynucleotide containing the repeating trinucleotide sequence, adenylyl-adenylyl-guanylate (poly AAG) has been shown to direct the synthesis of polyly-sine, polyarginine and polyglutamate in the in vitro amino acid incorporation system. In experiments on the stimulation of the binding of [ 14 C]aminoacyl-sRNA to ribosomes the following results
D.S. Jones, S. Nishimura, H. Hayatsu, H G Khorana, E. Ohtsuka, T. M. Jacob   +5 more
openaire   +2 more sources

Alkylation of Synthetic Polynucleotides

Science, 1964
The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine ...
David B. Ludlum, Albert J. Wahba, Robert C. Warner   +2 more
openaire   +3 more sources

Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe.

Chemical Communications, 2014
A label-free, oligonucleotide-based, switch-on luminescence detection method for T4 polynucleotide kinase activity has been developed using a novel G-quadruplex-selective luminescent Ir(iii) complex probe.
Hongzhang He, Ka-Ho Leung, Wei Wang, D. Chan, C. Leung, Dik‐Lung Ma   +5 more
semanticscholar   +1 more source

Amplified detection of T4 polynucleotide kinase activity by the coupled λ exonuclease cleavage reaction and catalytic assembly of bimolecular beacons.

Analytical Chemistry, 2014
The phosphorylation of nucleic acid catalyzed by polynucleotide kinase is an indispensible procedure involved in many vital cellular activities such as DNA recombination and DNA repair.
Ting Hou, Xiuzhong Wang, Xiaojuan Liu, Tingting Lu, Shufeng Liu, Feng Li   +5 more
semanticscholar   +1 more source

A WS2 nanosheet based sensing platform for highly sensitive detection of T4 polynucleotide kinase and its inhibitors.

Nanoscale, 2014
DNA phosphorylation, catalyzed by polynucleotide kinase (PNK), plays significant regulatory roles in many biological events. Here, a novel fluorescent nanosensor based on phosphorylation-specific exonuclease reaction and efficient fluorescence quenching ...
J. Ge, Li-Juan Tang, Q. Xi, Xi-Ping Li, R. Yu, Jian-hui Jiang, X. Chu   +6 more
semanticscholar   +1 more source