Results 31 to 40 of about 79,106 (244)
Carbethoxylation of Polynucleotides [PDF]
European Journal of Biochemistry, 1971 Diethyl pyrocarbonate has been shown to react with poly(A), poly(C) and poly(G) but poly(U) does not react. Diethyl pyrocarbonate appears to carbethoxylate amino groups on the bases. Poly(A) can bind one carbethoxy group per base but the binding capacity of poly(G) and poly(C) under non‐denaturing conditions is 0.32 and 0.23, respectively.
openaire +2 more sources
Regulation of metabolism by miR-378 [PDF]
, 2014 The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression.
Carrer, Michele, Olson, Eric N.
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Molecules, 2012 We report herein the synthesis and characterization of 9-(2-diallylaminoethyl) adenine. We evaluated two different synthetic routes starting with adenine where the optimal route was achieved through coupling of 9-(2-chloroethyl)adenine with diallylamine.
Karyn Usher +4 more
doaj +1 more source
DNA 3 '-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress [PDF]
, 2009 Oxidative stress is a major source of chromosome single-strand breaks (SSBs), and the repair of these lesions is retarded in neurodegenerative disease. The rate of the repair of oxidative SSBs is accelerated by XRCC1, a scaffold protein that is essential
Breslin, Claire, Caldecott, Keith W
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Error Analysis of Chemically Synthesized Polynucleotides
BioTechniques, 1998 Two single-stranded polynucleotide constructs, 123 and 126 nucleotides in length, were chemically synthesized using standard phosphoramidite chemistry.
Karl H. Hecker, Randolph L. Rill
doaj +1 more source
Micro-RNAs of the miR-15 family modulate cardiomyocyte survival and cardiac repair [PDF]
, 2015 A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of ...
Olson, Eric N., van Rooij, Eva
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Journal of Dermatological TreatmentBackground Facial aging is characterized by midface volume loss from structural and dermal atrophy.Objectives To evaluate the efficacy and safety of a hyaluronic acid–polynucleotide (HA–PN) hybrid filler for temporary restoration of anteromedial cheek ...
So Young Lee +2 more
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BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair [PDF]
, 2011 Repair of dsDNA breaks requires processing to produce 3′-terminated ssDNA. We biochemically reconstituted DNA end resection using purified human proteins: Bloom helicase (BLM); DNA2 helicase/nuclease; Exonuclease 1 (EXO1); the complex comprising MRE11 ...
Campbell, Judith L. +7 more
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Проблемы особо опасных инфекций, 2010 Cited are literary data related to the development of DNA vaccines against rabies virus. Research results regarding gene vaccination of different models of laboratory animals and different ways of vaccine introduction are presented.
I. V. Tuchkov, A. K. Nikiforov
doaj +1 more source
Pulling hairpinned polynucleotide chains: Does base-pair stacking interaction matter?
, 2001 Force-induced structural transitions both in relatively random and in designed single-stranded DNA (ssDNA) chains are studied theoretically. At high salt conditions, ssDNA forms compacted hairpin patterns stabilized by base-pairing and base-pair stacking
Haijun Zhou, Moroz J. D., Yang Zhang
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