Results 41 to 50 of about 89,786 (317)
Synthesis of Polynucleotide Analogs Containing a Polyvinyl Alcohol Backbone
Molecules, 2008 Water soluble homo-base polynucleotide analogues were synthesized in whichpolyvinyl alcohol and partially phosphonated polyvinyl alcohol constituted the backbones,onto which were grafted uracil or adenine via 1,3-dioxane spacers formed by acetalformation
Per Carlsen, Qiang Yu
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Translocation of structured polynucleotides through nanopores [PDF]
Physical Biology 1 (2004) 19-26, 2003 We investigate theoretically the translocation of structured RNA/DNA molecules through narrow pores which allow single but not double strands to pass. The unzipping of basepaired regions within the molecules presents significant kinetic barriers for the translocation process.
arxiv +1 more source
Molecules, 2012 We report herein the synthesis and characterization of 9-(2-diallylaminoethyl) adenine. We evaluated two different synthetic routes starting with adenine where the optimal route was achieved through coupling of 9-(2-chloroethyl)adenine with diallylamine.
Karyn Usher +4 more
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Stochastic sensing of polynucleotides using patterned nanopores [PDF]
Phys. Rev. X 2, 021002 (2012), 2012 The effect of the microscopic structure of a pore on polymer translocation is studied using Langevin dynamics simulation, and the consequence of introducing patterned stickiness inside the pore is investigated. It is found that the translocation process is extremely sensitive to the detailed structure of such patterns with faster than exponential ...
arxiv +1 more source
Clinical symptoms and molecular biology research in a family with oculopharyngeal muscular dystrophy
Chinese Journal of Contemporary Neurology and Neurosurgery, 2021 Objective To investigate the clinical symptoms and molecular biological characteristics in a family with oculopharyngeal muscular dystrophy (OPMD). Methods Clinical data of the family members were collected.
HUANG Kai +6 more
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Fluorescent labeling of plasmid DNA and mRNA : gains and losses of current labeling strategies [PDF]
, 2016 Live-cell imaging has provided the life sciences with insights into the cell biology and dynamics. Fluorescent labeling of target molecules proves to be indispensable in this regard. In this Review, we focus on the current fluorescent labeling strategies
Braeckmans, Kevin +2 more
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Error Analysis of Chemically Synthesized Polynucleotides
BioTechniques, 1998 Two single-stranded polynucleotide constructs, 123 and 126 nucleotides in length, were chemically synthesized using standard phosphoramidite chemistry.
Karl H. Hecker, Randolph L. Rill
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Dynamical characteristics of DNA kinks and antikinks [PDF]
Компьютерные исследования и моделирование, 2012 In this article in the frameworks of the sine-Gordon mode we have calculated the dynamical characteristics of kinks and antikinks activated in the homogeneous polynucleotide chains each if them contains only one of the types of the bases: adenines ...
L. V. Yakushevich +1 more
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Biomolecules, 2021 New analogs of the commercial asymmetric monomethine cyanine dyes thiazole orange (TO) and thiazole orange homodimer (TOTO) with hydroxypropyl functionality were synthesized and their properties in the presence of different nucleic acids were studied ...
Ivana Mikulin +9 more
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Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair [PDF]
, 2012 Microcephaly with early-onset, intractable seizures and developmental delay (MCSZ) is a hereditary disease caused by mutations in polynucleotide kinase/phosphatase (PNKP), a DNA strand break repair protein with DNA 5'-kinase and DNA 3'-phosphatase ...
Alexandra K. Walker +41 more
core +1 more source