Results 51 to 60 of about 93,488 (303)
Polynucleotide Phosphorylase Mediates a New Mechanism of Persister Formation in Escherichia coli
Despite the identification of many genes and pathways involved in the persistence phenomenon in bacteria, the mechanisms of persistence are not well understood.
Nan Wu+8 more
doaj +1 more source
Regulation of metabolism by miR-378 [PDF]
The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression.
Carrer, Michele, Olson, Eric N.
core +1 more source
FfRlpA2, a conserved Fusarium effector, functions as a protease inhibitor by hijacking the E3 ubiquitin ligase IbCHYR1 to degrade the resistance factor IbZnFR, thereby promoting Fusarium pathogenicity. Conversely, the high dosage Pro::IbZnFRHap2 allele was associated with resistance to root rot disease.
Huan Zhang+14 more
wiley +1 more source
Method for creating polynucleotide and polypeptide sequences [PDF]
The invention provides methods for evolving a polynucleotide toward acquisition of a desired property. Such methods entail incubating a population of parental polynucleotide variants under conditions to generate annealed polynucleotides comprising ...
Arnold, Frances+2 more
core +1 more source
Virus Replication as a Phenotypic Version of Polynucleotide Evolution
In this paper we revisit and adapt to viral evolution an approach based on the theory of branching process advanced by Demetrius, Schuster and Sigmund ("Polynucleotide evolution and branching processes", Bull. Math. Biol.
A. Eyre-Walker+64 more
core +1 more source
BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair [PDF]
Repair of dsDNA breaks requires processing to produce 3′-terminated ssDNA. We biochemically reconstituted DNA end resection using purified human proteins: Bloom helicase (BLM); DNA2 helicase/nuclease; Exonuclease 1 (EXO1); the complex comprising MRE11 ...
Campbell, Judith L.+7 more
core +3 more sources
The structure and assembly principles of a two‐component encapsulin nanocompartment shell are reported. The two‐component protein compartment self‐assembles from two distinct HK97‐fold shell proteins into a pseudo‐icosahedral protein shell with variable composition and irregular tiling.
Cassandra A. Dutcher+2 more
wiley +1 more source
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that causes various acute and chronic infections. It is intrinsically resistant to a variety of antibiotics. However, production of pyocins during SOS response sensitizes P.
Zheng Fan+11 more
doaj +1 more source
Linker region is required for efficient nuclear localization of polynucleotide kinase phosphatase.
Polynucleotide kinase phosphatase (PNKP) is a DNA repair factor with dual enzymatic functions, i.e., phosphorylation of 5'-end and dephosphorylation of 3'-end, which are prerequisites for DNA ligation and, thus, is involved in multiple DNA repair ...
Kaima Tsukada+2 more
doaj +1 more source
Rapid nanopore discrimination between single polynucleotide molecules.
A variety of different DNA polymers were electrophoretically driven through the nanopore of an alpha-hemolysin channel in a lipid bilayer. Single-channel recording of the translocation duration and current flow during traversal of individual ...
A. Meller+4 more
semanticscholar +1 more source