Results 61 to 70 of about 93,488 (303)

Colloquium: Physical approaches to DNA sequencing and detection [PDF]

, 2008
With the continued improvement of sequencing technologies, the prospect of genome-based medicine is now at the forefront of scientific research. To realize this potential, however, a revolutionary sequencing method is needed for the cost-effective and ...
Di Ventra, Massimiliano, Zwolak, Michael
core   +2 more sources

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

Presence of a classical RRM-fold palm domain in Thg1-type 3'- 5'nucleic acid polymerases and the origin of the GGDEF and CRISPR polymerase domains

Biology Direct, 2010
Background Almost all known nucleic acid polymerases catalyze 5'-3' polymerization by mediating the attack on an incoming nucleotide 5' triphosphate by the 3'OH from the growing polynucleotide chain in a template dependent or independent manner. The only
Aravind L, Iyer Lakshminarayan M, Anantharaman Vivek   +2 more
doaj   +1 more source

The endoribonucleolytic N-terminal half of Escherichia coli RNase E is evolutionarily conserved in Synechocystis sp. and other bacteria but not the C-terminal half, which is sufficient for degradosome assembly [PDF]

, 1998
Escherichia coli RNase E, an essential single-stranded specific endoribonuclease, is required for both ribosomal RNA processing and the rapid degradation of mRNA.
Jakobsen, J.S., Kaberdin, V.R., Lin-Chao, S., McDowall, K.J., Miczak, A., Von Gabain, A.   +5 more
core   +2 more sources

Pulling hairpinned polynucleotide chains: Does base-pair stacking interaction matter?

, 2001
Force-induced structural transitions both in relatively random and in designed single-stranded DNA (ssDNA) chains are studied theoretically. At high salt conditions, ssDNA forms compacted hairpin patterns stabilized by base-pairing and base-pair stacking
Haijun Zhou, Moroz J. D., Yang Zhang
core   +1 more source

Adiabatic differential scanning calorimetric study of divalent cation induced DNA - DPPC liposome formulation compacted for gene delivery

Brazilian Archives of Biology and Technology, 2004
Complexes between nucleic acids and phospholipid vesicles have been developed as stable non-viral gene delivery vehicles. Currently employed approach uses positively charged lipid species and a helper zwitterionic lipid, the latter being applied for the ...
Erhan Süleymanoglu
doaj   +1 more source

Mdm2 binding to a conformationally sensitive domain on p53 can be modulated by RNA [PDF]

, 2000
Biochemical characterisation of the interaction of mdm2 protein with p53 protein has demonstrated that full-length mdm2 does not bind stably to p53–DNA complexes, contrasting with C-terminal truncations of mdm2 which do bind stably to p53–DNA complexes ...
Abarzua, Blaydes, Blaydes, Borden, Borden, Bottger, Brown, Caron de Fromentel, Chen, Craig, Elenbaas, Freemont, Hansen, Hay, Honda, Hupp, Hupp, Hupp, Jeffrey, Kubbutat, Kussie, Lambert, Marechal, Marston, Midgley, Picksley, Selivanova, Shieh, Stephen, Unger   +29 more
core   +1 more source

Macromolecule‐Driven Supramolecular Polymerization Induced by Crowding Effects

Angewandte Chemie International Edition, Accepted Article.
Macromolecular crowding plays a crucial role in biological systems by regulating dynamic processes, yet its effects in fully synthetic environments remain largely unexplored. Here, we systematically investigate how excluded volume effects influence supramolecular polymerizations in organic media.
Joost van der Tol, Magda Dekker, Adam Muller, Puck Springintveld, E.W. Meijer, Ghislaine Vantomme   +5 more
wiley   +1 more source

Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases.

Molecular biology and evolution, 2005
The AID/APOBEC family (comprising AID, APOBEC1, APOBEC2, and APOBEC3 subgroups) contains members that can deaminate cytidine in RNA and/or DNA and exhibit diverse physiological functions (AID and APOBEC3 deaminating DNA to trigger pathways in adaptive ...
S. Conticello, Cornelia J F Thomas, Svend K. Petersen-Mahrt, M. Neuberger   +3 more
semanticscholar   +1 more source

DNA 3 '-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress [PDF]

, 2009
Oxidative stress is a major source of chromosome single-strand breaks (SSBs), and the repair of these lesions is retarded in neurodegenerative disease. The rate of the repair of oxidative SSBs is accelerated by XRCC1, a scaffold protein that is essential
Breslin, Claire, Caldecott, Keith W
core   +2 more sources