Results 61 to 70 of about 65,968 (266)
The Reaction of Formaldehyde with Polynucleotides
Journal of Biological Chemistry, 1961 Formaldehyde has been used extensively for chemically modifying proteins and for inactivating toxins and viruses, although the precise mode of its action is little understood. In the case of tobacco mosaic virus, however, Fraenkel-Conrat (1) and Staehelin (2) have shown that inactivation of the virus is due to interaction of formaldehyde with the amino
Robert Haselkorn, Paul Doty
openaire +3 more sources
The FEBS Journal, EarlyView.When overexpressed in Staphylococcus aureus, the type I toxins SprA1 and SprA2 form membrane pores, with SprA1 creating stable pores and SprA2 forming transient ones. Both induce concomitant membrane depolarization, ATP release, and growth arrest, while only SprA1 causes membrane permeabilization due to its stable pore formation.
Laurence Fermon +10 more
wiley +1 more source
Human FASTK preferentially binds single‐stranded and G‐rich RNA
The FEBS Journal, EarlyView.Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak +7 more
wiley +1 more source
Polynucleotide phosphorylase has an impact on cell biology of Campylobacter jejuni
Frontiers in Cellular and Infection Microbiology, 2012 Polynucleotide phosphorylase, encoded by the pnp gene, is known to degrade mRNA, mediating post-transcriptional regulation and may affect cellular functions. The role of PNPase is pleiotropic.
Nabila eHaddad +12 more
doaj +1 more source
Blood group O expression in normal tissues and tumors
The FEBS Journal, EarlyView.The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, specifically detect the H antigen on glycan microarrays, glycoproteins, and human cells.
Ea Kristine Clarisse Tulin +11 more
wiley +1 more source
Derivatization of unprotected polynucleotides
Nucleic Acids Research, 1983 A simple and efficient method for attaching amines to the terminal 5'-phosphate of unprotected oligonucleotides or nucleic acids in aqueous solution is described. The method is applicable to low molecular-weight amines, polypeptides, or proteins. The terminal 5'-phosphate of an oligonucleotide or nucleic acid reacts with a water-soluble carbodiimide in
Barbara C.F. Chu +2 more
openaire +4 more sources
Journal of Integrative Plant Biology, EarlyView.The Arabidopsis bZIP3 protein works in conjunction with ASYMMETRIC LEAVES1 to facilitate the function of the CONSTANS protein in activating FLOWERING LOCUS T expression at the end of the day in a day length‐dependent manner. ABSTRACT Plants monitor daylength to synchronize their flowering time with their surroundings and thus maximize reproductive ...
Wonbok Lee +10 more
wiley +1 more source
A Chromosome Inversion Creates a Supergene for Sex and Colour in Lake Malawi Cichlids
Molecular Ecology, EarlyView.ABSTRACT Cichlid fishes have the highest rates of evolutionary turnover of sex chromosomes among vertebrates. Many large structural polymorphisms in the radiation of cichlids in Lake Malawi are associated with sex chromosomes and may also carry adaptive variation.
Kristen A. Behrens +10 more
wiley +1 more source
A nanometric DNA-zwitterionic phospholipid unilamellar vesicle formulation compacted for gene delivery: Adiabatic differential scanning microcalorimetric study [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2004 Complexes between nucleic acids and phospholipid vesicles have been developed as stable non-viral gene delivery vehicles. Currently employed approach uses positively charged lipid species and a helper zwitterionic lipid, the latter being applied for the ...
Erhan S u˙˙leymano(glu
doaj
Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair
Nucleic Acids Research, 2011 Mutations in mitochondrial DNA (mtDNA) are implicated in a broad range of human diseases and in aging. Compared to nuclear DNA, mtDNA is more highly exposed to oxidative damage due to its proximity to the respiratory chain and the lack of protection ...
Nasser Tahbaz, Sudip Subedi, M. Weinfeld
semanticscholar +1 more source