Results 71 to 80 of about 74,970 (276)

Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma [PDF]

, 2009
Current treatment options for neuroblastoma fail to eradicate the disease in the majority of high-risk patients, clearly mandating development of innovative therapeutic strategies. Gene therapy represents a promising approach for reversing the neoplastic
Ardelt, Arnold, Beck, Benito, Brodeur, Chan, Cinatl, Cinatl, D'Alessio, Hellemans, Holmes, Jasty, Kotchetkov, Lebedeva, Lebedeva, Leszczyniecka, Leszczyniecka, Maris, McConville, Michaelis, Pattyn, Pattyn, Ross, Sarkar, Sarkar, Sarkar, Sarkar, Sarkar, Sarkar, Su, Tweddle, Van Maerken, Vandesompele, Vandesompele, Vasandani, Vasandani, Youle, Young   +37 more
core   +2 more sources

A Novel Protein NLRP12‐119aa that Prevents Rhabdovirus Replication by Disrupting the RNP Complex Formation

Advanced Science, Volume 12, Issue 12, March 27, 2025.
The NLRP12‐119aa protein exerts its antiviral effect by two distinct mechanisms. First, it competes with the N protein of rhabdoviruses for binding to the viral leRNA, thereby preventing the formation of the RNP complex. Second, NLRP12‐119aa directly interacts with the rhabdovirus N protein, destabilizing it and promoting its degradation, which ...
Weiwei Zheng, Xiangxiang Zhu, Tongtong Zhu, Qiang Luo, Yan Zhao, Tianjun Xu   +5 more
wiley   +1 more source

Presence of a classical RRM-fold palm domain in Thg1-type 3'- 5'nucleic acid polymerases and the origin of the GGDEF and CRISPR polymerase domains

Biology Direct, 2010
Background Almost all known nucleic acid polymerases catalyze 5'-3' polymerization by mediating the attack on an incoming nucleotide 5' triphosphate by the 3'OH from the growing polynucleotide chain in a template dependent or independent manner. The only
Aravind L, Iyer Lakshminarayan M, Anantharaman Vivek   +2 more
doaj   +1 more source

Polynucleotide phosphorylase: Not merely an RNase but a pivotal post-transcriptional regulator. [PDF]

PLoS Genetics, 2018
Almost 60 years ago, Severo Ochoa was awarded the Nobel Prize in Physiology or Medicine for his discovery of the enzymatic synthesis of RNA by polynucleotide phosphorylase (PNPase).
Todd A Cameron, Lisa M Matz, Nicholas R De Lay   +2 more
doaj   +1 more source

Method for creating polynucleotide and polypeptide sequences [PDF]

, 2003
The invention provides methods for evolving a polynucleotide toward acquisition of a desired property. Such methods entail incubating a population of parental polynucleotide variants under conditions to generate annealed polynucleotides comprising ...
Arnold, Frances, Shao, Zhixin, Volkov, Alexander   +2 more
core   +1 more source

Micro-RNAs of the miR-15 family modulate cardiomyocyte survival and cardiac repair [PDF]

, 2015
A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of ...
Olson, Eric N., van Rooij, Eva
core   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

Pseudomonas aeruginosa Polynucleotide Phosphorylase Contributes to Ciprofloxacin Resistance by Regulating PrtR

Frontiers in Microbiology, 2019
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that causes various acute and chronic infections. It is intrinsically resistant to a variety of antibiotics. However, production of pyocins during SOS response sensitizes P.
Zheng Fan, Hao Chen, Mei Li, Xiaolei Pan, Weixin Fu, Huan Ren, Ronghao Chen, Fang Bai, Yongxin Jin, Zhihui Cheng, Shouguang Jin, Weihui Wu   +11 more
doaj   +1 more source

Dual targeting of MIR-208 and MIR-499 in the treatment of cardiac disorders [PDF]

, 2014
The present invention provides a method of treating or preventing cardiac disorders in a subject in need thereof by inhibiting the expression or function of both miR-499 and miR-208 in the heart cells of the subject. In particular, specific protocols for
Olson, Eric S., van Rooij, Eva
core   +1 more source

Linker region is required for efficient nuclear localization of polynucleotide kinase phosphatase.

PLoS ONE, 2020
Polynucleotide kinase phosphatase (PNKP) is a DNA repair factor with dual enzymatic functions, i.e., phosphorylation of 5'-end and dephosphorylation of 3'-end, which are prerequisites for DNA ligation and, thus, is involved in multiple DNA repair ...
Kaima Tsukada, Yoshihisa Matsumoto, Mikio Shimada   +2 more
doaj   +1 more source