New Fractal Soliton Solutions and Sensitivity Visualization for Double-Chain DNA Model
This article discusses dynamics of the fractal double-chain deoxyribonucleic acid model. This structure contains two long elastic homogeneous strands that serve as two polynucleotide chains of deoxyribonucleic acid molecules, bounded by an elastic ...
Zara Hassan+7 more
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Viral Evolution and Adaptation as a Multivariate Branching Process [PDF]
In the present work we analyze the problem of adaptation and evolution of RNA virus populations, by defining the basic stochastic model as a multivariate branching process in close relation with the branching process advanced by Demetrius, Schuster and Sigmund ("Polynucleotide evolution and branching processes", Bull. Math. Biol. 46 (1985) 239-262), in
arxiv +1 more source
The Reaction of Formaldehyde with Polynucleotides
Formaldehyde has been used extensively for chemically modifying proteins and for inactivating toxins and viruses, although the precise mode of its action is little understood. In the case of tobacco mosaic virus, however, Fraenkel-Conrat (1) and Staehelin (2) have shown that inactivation of the virus is due to interaction of formaldehyde with the amino
Robert Haselkorn, Paul Doty
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Polynucleotide phosphorylase has an impact on cell biology of Campylobacter jejuni
Polynucleotide phosphorylase, encoded by the pnp gene, is known to degrade mRNA, mediating post-transcriptional regulation and may affect cellular functions. The role of PNPase is pleiotropic.
Nabila eHaddad+12 more
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Nickel (II) Ions Interaction with Polynucleotides and DNA of Different GC Composition [PDF]
The goal of the work was to study the role of GC alternative dimmers in the binding of DNA with Ni (II) ions. The method of ultraviolet difference spectroscopy has been applied to investigate Ni (II) ions interactions with DNA extracted from Clostridium perfringens, Mice liver (C3HA line), Calf thymus, Salmon sperm, Herring sperm, E.coli, Micrococcus ...
arxiv
Derivatization of unprotected polynucleotides
A simple and efficient method for attaching amines to the terminal 5'-phosphate of unprotected oligonucleotides or nucleic acids in aqueous solution is described. The method is applicable to low molecular-weight amines, polypeptides, or proteins. The terminal 5'-phosphate of an oligonucleotide or nucleic acid reacts with a water-soluble carbodiimide in
Barbara C.F. Chu+2 more
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Driven Polymer Translocation Through a Narrow Pore [PDF]
Motivated by experiments in which a polynucleotide is driven through a proteinaceous pore by an electric field, we study the diffusive motion of a polymer threaded through a narrow channel with which it may have strong interactions. We show that there is a range of polymer lengths in which the system is approximately translationally invariant, and we ...
arxiv +1 more source
A nanometric DNA-zwitterionic phospholipid unilamellar vesicle formulation compacted for gene delivery: Adiabatic differential scanning microcalorimetric study [PDF]
Complexes between nucleic acids and phospholipid vesicles have been developed as stable non-viral gene delivery vehicles. Currently employed approach uses positively charged lipid species and a helper zwitterionic lipid, the latter being applied for the ...
Erhan S u˙˙leymano(glu
doaj
Synthesis and polymerization of 1-(2-diallylaminoethyl)pyrimidines
We report the preparation and characterization of three pyrimidine-based monomers, specifically: 1-(2-diallylaminoethyl)uracil, 1-(2-diallylaminoethyl)thymine and 1-(2-diallylaminoethyl)cytosine.
Jomana Elaridi+5 more
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Naphthalene diimide bis-guanidinio-carbonyl-pyrrole as a pH-switchable threading DNA intercalator
A novel naphthalene diimde analogue (NDI) equipped at the imide positions with two guanidinio-carbonyl-pyrrole (GCP) pendant arms interacted significantly stronger with ds-DNA at pH 5 than at pH 7, due to reversible protonation of the GCP arms.
Poulami Jana+3 more
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