Results 81 to 90 of about 93,488 (303)

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Polynucleotide-Chitosan Complex, an Insoluble but Reactive Form of Polynucleotide.

Chemical and Pharmaceutical Bulletin, 1997
DNA formed an insoluble complex on mixing with chitosan (poly-D-glucosamine) in solution. The DNA content of the complex was about 50% and the DNA remained insoluble in aqueous media of pH 2-7%; e.g., on treatment of the DNA-chitosan complex with phosphate-buffered saline at pH 7 and 37 degrees C for 26 h, the DNA released into the aqueous phase was ...
Takashi Kubo, Yuji Tanaka, Kazuo Negishi, Hikoya Hayatsu   +3 more
openaire   +3 more sources

Prediction of Proliferation Rate of Pre‐Osteoblasts Using Raman Spectroscopy and Machine Learning Models

Journal of Raman Spectroscopy, EarlyView.
The main processes involved in predicting the pre–osteoblast proliferation rate using Raman spectroscopy and machine learning. ABSTRACT This novel study focuses on using Raman spectroscopy and machine learning (ML) models to forecast the murine pre‐osteoblast (OB) proliferation rate.
Sai S. Sudha, Angshuman Baradwaz, Ahmad Y. Javaid, Ambalangodage C. Jayasuriya   +3 more
wiley   +1 more source

New Fractal Soliton Solutions and Sensitivity Visualization for Double-Chain DNA Model

Journal of Function Spaces, 2022
This article discusses dynamics of the fractal double-chain deoxyribonucleic acid model. This structure contains two long elastic homogeneous strands that serve as two polynucleotide chains of deoxyribonucleic acid molecules, bounded by an elastic ...
Zara Hassan, Nauman Raza, Abdel-Haleem Abdel-Aty, Mohammed Zakarya, Riaz Ur Rahman, Adeela Yasmeen, Abdisalam Hassan Muse, Emad E. Mahmoud   +7 more
doaj   +1 more source

Dual targeting of MIR-208 and MIR-499 in the treatment of cardiac disorders [PDF]

, 2014
The present invention provides a method of treating or preventing cardiac disorders in a subject in need thereof by inhibiting the expression or function of both miR-499 and miR-208 in the heart cells of the subject. In particular, specific protocols for
Olson, Eric S., van Rooij, Eva
core   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

Scaling and Visualization of Nucleotide Sequences [PDF]

EPJ Web of Conferences, 2019
Algorithms for scaling and visualization of nucleotide sequences developed in this study allow identifying relationships between the biochemical parameters of DNA and RNA molecules with scale invariance, fractal clusters, nonlinear ordering and symmetry ...
Stepanyan Ivan V., Khussein Abbakar M.
doaj   +1 more source

The Reaction of Formaldehyde with Polynucleotides

Journal of Biological Chemistry, 1961
Formaldehyde has been used extensively for chemically modifying proteins and for inactivating toxins and viruses, although the precise mode of its action is little understood. In the case of tobacco mosaic virus, however, Fraenkel-Conrat (1) and Staehelin (2) have shown that inactivation of the virus is due to interaction of formaldehyde with the amino
Robert Haselkorn, Paul Doty
openaire   +3 more sources

Solvation Effects on Hole Mobility in the Poly G/Poly C Duplex

, 2012
Theoretical calculations of solvation contribution to hole energy in a polynucleotide chain give very low hole mobility values at zero temperature, \mu < 10^{-3} cm^2/(V s).
Fialko, N. S., Lakhno, V. D.
core   +1 more source

Organic Reactivity Matters for the Emergence of Life: Kinetic Barriers and Molecular Diversity Are Suggested as Crucial Factors by Emerging Autonomous System Models

ChemSystemsChem, EarlyView.
Self‐organisation may result from organic systems fed with free energy provided that reactivity becomes a determining factor. The propensity of carbon to form covalent bonds can give rise to kinetically stable thermodynamically activated compounds possibly undergoing non‐linear kinetic processes.
Robert Pascal
wiley   +1 more source