Results 101 to 110 of about 40,696 (222)
Role of the particle's stepping cycle in an asymmetric exclusion process: A model of mRNA translation [PDF]
Phys. Rev. E 81, 051904 (2010), 2009 Messenger RNA translation is often studied by means of statistical-mechanical models based on the Asymmetric Simple Exclusion Process (ASEP), which considers hopping particles (the ribosomes) on a lattice (the polynucleotide chain). In this work we extend this class of models and consider the two fundamental steps of the ribosome's biochemical cycle ...
arxiv +1 more source
The FASEB Journal, 2017 DNA double strand breaks, if unrepaired, pose a threat to the cell because they can cause a wide variety of genetic alteration and apoptosis. Therefore, DNA double‐strand break repair pathways are critical for the survival of all organisms.
M. Spence, Lee A. Uranga, S. Lusetti
semanticscholar +1 more source
Antibiotic influx and efflux in Pseudomonas aeruginosa: Regulation and therapeutic implications
Microbial Biotechnology, Volume 17, Issue 5, May 2024.This work comprehensively summarized the regulatory networks of the major porin proteins and efflux pumps that play critical roles in antibiotic influx and efflux in Pseudomonas aeruginosa. It also discussed promising therapeutic approaches to combat multidrug‐resistant P.
Weiyan Wu, Jiahui Huang, Zeling Xu
wiley +1 more source
A Gibbs approach to Chargaff's second parity rule [PDF]
J. Statist. Phys. 146(2), 408-422, 2012, 2011 Chargaff's second parity rule (CSPR) asserts that the frequencies of short polynucleotide chains are the same as those of the complementary reversed chains. Up to now, this hypothesis has only been observed empirically and there is currently no explanation for its presence in DNA strands.
arxiv +1 more source
The biological essence of synthetic lethality: Bringing new opportunities for cancer therapy
MedComm – Oncology, Volume 3, Issue 1, March 2024.Synthetic lethality exploits vulnerabilities in cancer cells, targeting aberrant pathways resulting from genetic mutations or pharmacological interventions. This strategy extends beyond the tumor cells to include the tumor microenvironment, such as stromal cells and signaling molecules, to enhance treatment responses and eradicate cancer.
Meiyi Ge +4 more
wiley +1 more source
The effect of trypsin digestion on the activities of polynucleotide phosphorylase [PDF]
Biochemical Journal, 1967 1. Treatment of Micrococcus lysodeikticus polynucleotide phosphorylase (nucleoside diphosphate–polynucleotide nucleotidyltransferase) with trypsin causes a preferential loss of its cytidine diphosphate and uridine diphosphate polymerization activities. 2.
P. S. Fitt, E. A. Fitt
openaire +3 more sources
Protein Science, Volume 33, Issue 2, February 2024.Abstract Escherichia coli is one of the most widely utilized hosts for production of recombinant membrane proteins (MPs). Bacterial MP production, however, is usually accompanied by severe toxicity and low‐level volumetric accumulation. In previous work, we had discovered that co‐expression of RraA, an inhibitor of the RNA‐degrading activity of RNase E,
Eleni Vasilopoulou +2 more
wiley +1 more source
Distinct co-evolution patterns of genes associated to DNA polymerase III DnaE and PolC
BMC Genomics, 2012 Background Bacterial genomes displaying a strong bias between the leading and the lagging strand of DNA replication encode two DNA polymerases III, DnaE and PolC, rather than a single one.
Engelen Stefan +3 more
doaj +1 more source
Viral Evolution and Adaptation as a Multivariate Branching Process [PDF]
, 2011 In the present work we analyze the problem of adaptation and evolution of RNA virus populations, by defining the basic stochastic model as a multivariate branching process in close relation with the branching process advanced by Demetrius, Schuster and Sigmund ("Polynucleotide evolution and branching processes", Bull. Math. Biol. 46 (1985) 239-262), in
arxiv +1 more source
PNPase knockout results in mtDNA loss and an altered metabolic gene expression program.
PLoS ONE, 2018 Polynucleotide phosphorylase (PNPase) is an essential mitochondria-localized exoribonuclease implicated in multiple biological processes and human disorders.
Eriko Shimada +11 more
doaj +1 more source