Results 101 to 110 of about 43,981 (239)
The FASEB Journal, 2017 DNA double strand breaks, if unrepaired, pose a threat to the cell because they can cause a wide variety of genetic alteration and apoptosis. Therefore, DNA double‐strand break repair pathways are critical for the survival of all organisms.
M. Spence, Lee A. Uranga, S. Lusetti
semanticscholar +1 more source
Single‐Molecule Electrical Profiling of Peptides and Proteins
Advanced Science, Volume 11, Issue 28, July 24, 2024.This work presents a timely overview of the prominent research progress in peptide and protein‐related studies through single‐molecule electrical techniques, including single‐molecule junction, single‐molecule field‐effect transistor (FET), and nanopore.
Hongyu Ju +6 more
wiley +1 more source
The effect of trypsin digestion on the activities of polynucleotide phosphorylase [PDF]
Biochemical Journal, 1967 1. Treatment of Micrococcus lysodeikticus polynucleotide phosphorylase (nucleoside diphosphate–polynucleotide nucleotidyltransferase) with trypsin causes a preferential loss of its cytidine diphosphate and uridine diphosphate polymerization activities. 2.
P. S. Fitt, E. A. Fitt
openaire +3 more sources
RNA turnover: The helicase story unwinds [PDF]
, 1996 Recent results show that RNA helicases play important roles in RNA decay, both as exoribonuclease accessory factors and in communicating signals to RNA decay ...
Jacobs Anderson, John S, Parker, Roy
core +1 more source
Antibiotic influx and efflux in Pseudomonas aeruginosa: Regulation and therapeutic implications
Microbial Biotechnology, Volume 17, Issue 5, May 2024.This work comprehensively summarized the regulatory networks of the major porin proteins and efflux pumps that play critical roles in antibiotic influx and efflux in Pseudomonas aeruginosa. It also discussed promising therapeutic approaches to combat multidrug‐resistant P.
Weiyan Wu, Jiahui Huang, Zeling Xu
wiley +1 more source
Maturation of Polycistronic mRNAs by the Endoribonuclease RNase Y and Its Associated Y-Complex in Bacillus Subtilis [PDF]
, 2018 Endonucleolytic cleavage within polycistronic mRNAs can lead to differential stability, and thus discordant abundance, among cotranscribed genes. RNase Y, the major endonuclease for mRNA decay in Bacillus subtilis, was originally identified for its ...
DeLoughery, Aaron +3 more
core +1 more source
Distinct co-evolution patterns of genes associated to DNA polymerase III DnaE and PolC
BMC Genomics, 2012 Background Bacterial genomes displaying a strong bias between the leading and the lagging strand of DNA replication encode two DNA polymerases III, DnaE and PolC, rather than a single one.
Engelen Stefan +3 more
doaj +1 more source
The biological essence of synthetic lethality: Bringing new opportunities for cancer therapy
MedComm – Oncology, Volume 3, Issue 1, March 2024.Synthetic lethality exploits vulnerabilities in cancer cells, targeting aberrant pathways resulting from genetic mutations or pharmacological interventions. This strategy extends beyond the tumor cells to include the tumor microenvironment, such as stromal cells and signaling molecules, to enhance treatment responses and eradicate cancer.
Meiyi Ge +4 more
wiley +1 more source
Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA [PDF]
, 2002 We characterised the human hSuv3p protein belonging to the family of NTPases/helicases. In yeast mitochondria the hSUV3 orthologue is a component of the degradosome complex and participates in mtRNA turnover and processing, while in Caenorhabditis ...
Awiszus, K. +10 more
core +2 more sources
Protein Science, Volume 33, Issue 2, February 2024.Abstract Escherichia coli is one of the most widely utilized hosts for production of recombinant membrane proteins (MPs). Bacterial MP production, however, is usually accompanied by severe toxicity and low‐level volumetric accumulation. In previous work, we had discovered that co‐expression of RraA, an inhibitor of the RNA‐degrading activity of RNase E,
Eleni Vasilopoulou +2 more
wiley +1 more source