The biological essence of synthetic lethality: Bringing new opportunities for cancer therapy
MedComm – Oncology, Volume 3, Issue 1, March 2024.Synthetic lethality exploits vulnerabilities in cancer cells, targeting aberrant pathways resulting from genetic mutations or pharmacological interventions. This strategy extends beyond the tumor cells to include the tumor microenvironment, such as stromal cells and signaling molecules, to enhance treatment responses and eradicate cancer.
Meiyi Ge +4 more
wiley +1 more source
Knocking out ACR2 does not affect arsenic redox status in Arabidopsis thaliana: implications for As detoxification and accumulation in plants [PDF]
, 2012 Peer reviewedPublisher ...
David E Salt +8 more
core +7 more sources
Protein Science, Volume 33, Issue 2, February 2024.Abstract Escherichia coli is one of the most widely utilized hosts for production of recombinant membrane proteins (MPs). Bacterial MP production, however, is usually accompanied by severe toxicity and low‐level volumetric accumulation. In previous work, we had discovered that co‐expression of RraA, an inhibitor of the RNA‐degrading activity of RNase E,
Eleni Vasilopoulou +2 more
wiley +1 more source
Cleavage of 3′-terminal adenosine by archaeal ATP-dependent RNA ligase [PDF]
, 2017 Methanothermobacter thermoautotrophicus RNA ligase (MthRnl) catalyzes formation of phosphodiester bonds between the 5′-phosphate and 3′-hydroxyl termini of single-stranded RNAs.
Gollnick Paul +3 more
core +3 more sources
PNPase knockout results in mtDNA loss and an altered metabolic gene expression program.
PLoS ONE, 2018 Polynucleotide phosphorylase (PNPase) is an essential mitochondria-localized exoribonuclease implicated in multiple biological processes and human disorders.
Eriko Shimada +11 more
doaj +1 more source
Hamster leukemia virus: lack of endogenous DNA synthesis and unique structure of its DNA polymerase [PDF]
, 1974 Infectious hamster leukemia virus (HaLV) contains a DNA polymerase different from those of murine and avian viruses. No endogenous reaction directed by the 60 to 70S RNA of HaLV could be demonstrated in detergenttreated HaLV virions, nor could the ...
Baltimore, David +3 more
core
Modulation of Neurogenesis through the Promotion of Energy Production Activity Is behind the Antidepressant-Like Effect of Colonial Green Alga, Botryococcus braunii [PDF]
, 2017 Algae have been recognized as important resources providing functional components due to their capacity to exert beneficial effects on health. Therefore, there is increasing interest in investigating the biological activity of algae.
Demura Mikihide +6 more
core +1 more source
U.S. Patent Literature Survey of Agrobacterium-Mediated Transformation of Sweet Potato (Ipomoea Batatas) [PDF]
, 2007 A team of researchers and patent information scientists at Franklin Pierce Law Center were asked to evaluate the patent and literature landscape related to the Agrobacterium-mediated transformation in sweet potato with respect to the U.S.
Cavicchi, Jon R. +3 more
core +1 more source
Synthetic and Systems Biotechnology, 2017 The usefulness of genetic/metabolic engineering for further improvement of industrial strains is subject of discussion because of the general lack of knowledge on genetic alterations introduced by iterative cycles of random mutagenesis in such strains ...
Eser Ünsaldı +4 more
doaj +1 more source
Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA [PDF]
, 2002 We characterised the human hSuv3p protein belonging to the family of NTPases/helicases. In yeast mitochondria the hSUV3 orthologue is a component of the degradosome complex and participates in mtRNA turnover and processing, while in Caenorhabditis ...
Awiszus, K. +10 more
core +2 more sources