Results 71 to 80 of about 7,381 (220)

Astragaloside IV Reprograms Spatial Glycolytic Metabolism in Diabetic Kidney: A Microenvironment‐Targeted Immunometabolic Therapeutic Strategy

Food Frontiers, Volume 7, Issue 3, May 2026.
Diabetic nephropathy (DN) is driven by spatially organized immunometabolic dysfunction. Integrating high‐resolution spatial transcriptomics (10× Visium HD) and metabolomics (MALDI‐MSI), we mapped a pathogenic glycolytic blockade within diabetic kidney microenvironments.
Shi Qiu, Zhibo Wang, Sifan Guo, Dandan Xie, Ying Cai, Xian Wang, Yan Wang, Xiaodan Yu, Jinxuan Chai, Hong Yao, Chunsheng Lin, Qiang Yang, Yu Guan, Qiqi Zhao, Songqi Tang, Wenjie Sun, Yiqiang Xie, Aihua Zhang   +17 more
wiley   +1 more source

Exploiting polypharmacology for drug target deconvolution [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Protein kinase inhibitors represent a major class of anticancer drugs, which are notoriously unspecific. Efforts to exploit the polypharmacology of inhibitors for target deconvolution have met with little success. Our significant contribution is to apply regularized regression to kinase expression and kinase profiling on a large ...
Taranjit Singh, Gujral, Leonid, Peshkin, Marc W, Kirschner   +2 more
openaire   +2 more sources

Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t

Biomedicines, 2023
The ‘entourage effect’ term was originally coined in a pre-clinical study observing endogenous bio-inactive metabolites potentiating the activity of a bioactive endocannabinoid.
Catalina Christensen, Martin Rose, Claus Cornett, Morten Allesø   +3 more
doaj   +1 more source

Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy. [PDF]

, 2014
Activating mutations in FLT3 confer poor prognosis for individuals with acute myeloid leukemia (AML). Clinically active investigational FLT3 inhibitors can achieve complete remissions but their utility has been hampered by acquired resistance and ...
He, Bai-Liang, He, Bai-Liang, Lasater, Elisabeth A, Leung, Anskar Yh, Lin, Kimberly, Lopez, Michael S, Shah, Neil P, Shokat, Kevan M, Smith, Catherine C, Warkentin, Alexander A   +9 more
core  

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains [PDF]

, 2018
Bromodomains have been pursued intensively over the past several years as emerging targets for the development of anticancer and anti-inflammatory agents.
Alessi, Dario R., Becht, Kelly, Blacklow, Stephen C., Bradner, James E., Buckley, Dennis L., Dai, Lingling, Deng, Xianming, DiBona, Amy, Diéguez-Martínez, Nora, Erazo, Tatiana, Fedorov, Oleg, Ferguson, Fleur M., Gomez, Nestor, Gray, Nathanael S., Hao, Mingfeng, Kim, Nam Doo, Lizcano, Jose M., Massefski, Walter, McKeown, Michael R., Muñoz-Guardiola, Pau, Offei-Addo, Nana Kwaku, Park, Paul M., Qi, Jun, Roberts, Justin M., Sim, Taebo, Wang, Jinhua, Xu, Xiang, Zhang, Jinwei   +27 more
core   +3 more sources

Neural Correlates of Cognitive Improvement After Virtual Reality‐Based Cognitive Remediation in Psychosis and Mood Disorders: A Randomized Controlled Trial

Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 553-562, May 2026.
ABSTRACT Introduction Cognitive impairment in mood disorders and schizophrenia spectrum disorders hampers patients' clinical and functional outcomes. A key challenge in pro‐cognitive treatment development is the limited insight into the underlying neurocircuitry correlates of cognitive changes.
Viktoria Damgaard, Andreas Elleby Jespersen, Ida Kruse Søndergaard, Anders Lumbye, Maj Vinberg, Louise Birkedal Glenthøj, Merete Nordentoft, Anjali Sankar, Gitte Moos Knudsen, Julian Macoveanu, Kamilla Woznica Miskowiak   +10 more
wiley   +1 more source

Antibacterial N-Arylcinnamamides as Anti-inflammatory Agents

Proceedings, 2019
A series of ring-substituted N-arylcinnamamides was prepared, characterized, and investigatedfor their antimicrobial efficacy in detail [...]
Jiri Kos, Lubos Danisovic, Zuzana Varchulova Novakova, Radoslav Zamborsky, Ferdinand Devinsky, Josef Jampilek   +5 more
doaj   +1 more source

Discovery of Novel Inhibitors Targeting Multi-UDP-hexose Pyrophosphorylases as Anticancer Agents

Molecules, 2020
To minimize treatment toxicities, recent anti-cancer research efforts have switched from broad-based chemotherapy to targeted therapy, and emerging data show that altered cellular metabolism in cancerous cells can be exploited as new venues for targeted ...
Yueqin Yang, Hariprasad Vankayalapati, Manshu Tang, Yingbo Zheng, Yingri Li, Cong Ma, Kent Lai   +6 more
doaj   +1 more source

Anticancer metallohelices: nanomolar potency and high selectivity [PDF]

, 2015
A range of new helicate-like architectures have been prepared via highly diastereoselective self-assembly using readily accessible starting materials. Six pairs of enantiomers [Fe2L3]Cl4.nH2O (L = various bidentate ditopic ligands NN–NN) show very good ...
Allison, Allison, Andrews, Brabec, Brabec, Bunz, Cao, Cardo, Daborn, Deeth, Deeth, Dunn, Eggert, Faulkner, Grimme, Hanahan, Howson, Howson, Howson, Howson, Howson, Kaner, Kennedy, Kennedy, Kerckhoffs, Klamt, Lee, Lehn, Li, Malina, Malina, Malina, Meacham, Moffat, Neese, Pathak, Persidis, Reynolds, Richards, Sams-Dodd, Schmidt, Seredyuk, Soussi, Swinney, Tait, Verheul, Yu   +46 more
core   +1 more source

The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Konstantina Nikovia, Michael Kapsalis, Michael Georgoulakis, Athanasios Panousis, Constantinos G. Neochoritis   +4 more
wiley   +1 more source