In Combo Studies for the Optimization of 5-Aminoanthranilic Acid Derivatives as Potential Multitarget Drugs for the Management of Metabolic Syndrome [PDF]
Pharmaceuticals, 2022 Metabolic syndrome is a set of risk factors that consist of abdominal obesity, arterial hypertension, alterations in the lipid profile, and hyperglycemia.
Edwin Chávez-Gutiérrez +13 more
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Evaluation of multitarget drugs on the expression of cocaine-induced locomotor sensitization in male rats: A comparative study [PDF]
HeliyonPurpose: — Cocaine use disorder (CUD) is a complex disease. Several studies have shown the efficacy of multitarget drugs used to treat CUD. Here we compare the efficacy of mirtazapine (MIR), pindolol (PIN), fluoxetine (FLX), risperidone (RIS), trazodone (
Susana Barbosa-Méndez +1 more
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Multitarget drugs as potential therapeutic agents for alzheimer’s disease. A new family of 5-substituted indazole derivatives as cholinergic and BACE1 inhibitors [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Multitarget drugs are a promising therapeutic approach against Alzheimer’s disease. In this work, a new family of 5-substituted indazole derivatives with a multitarget profile including cholinesterase and BACE1 inhibition is described.
Pedro González-Naranjo +9 more
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Synthesis, Antiplasmodial, and Antileukemia Activity of Dihydroartemisinin–HDAC Inhibitor Hybrids as Multitarget Drugs [PDF]
Pharmaceuticals, 2022 Artemisinin-based combination therapies (ACTs) are the gold standard for the treatment of malaria, but the efficacy is threatened by the development of parasite resistance.
Lukas von Bredow +11 more
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Xanthine–Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases [PDF]
Biomolecules, 2023 Multitarget drugs based on a hybrid dopamine–xanthine core were designed as potential drug candidates for the treatment of neurodegenerative diseases.
Michał Załuski +10 more
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Natural products, an important resource for discovery of multitarget drugs and functional food for regulation of hepatic glucose metabolism [PDF]
Drug Design, Development and Therapy, 2018 Jian Li,1,* Haiyang Yu,2,* Sijian Wang,1 Wei Wang,3 Qian Chen,1 Yanmin Ma,2 Yi Zhang,1 Tao Wang1 1Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, 2Department of Phytochemistry, Institute of Traditional Chinese Medicine, Tianjin ...
Li J +7 more
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Multitarget Drugs: an Epigenetic Epiphany [PDF]
ChemMedChem, 2016 AbstractEpigenetics refers to changes in a biological phenotype that are not due to an underlying change in genotype. In eukaryotes, epigenetics involves a set of chemical modifications of the DNA and the histone proteins in nucleosomes. These dynamic changes are carried out by enzymes and modulate protein–protein and protein–nucleic acid interactions ...
A Ganesan
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Frontiers in Chemistry, 2020 The design of multitarget drugs is an essential area of research in Medicinal Chemistry since they have been proposed as potential therapeutics for the management of complex diseases. However, defining a multitarget drug is not an easy task. In this work,
Juan Francisco Sánchez-Tejeda +3 more
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Computational Identification of Potent Multitarget Natural Ligands for Alzheimer’s Disease Therapeutics [PDF]
ScientificaAlzheimer’s disease (AD), a complex neurodegenerative disorder, urgently necessitates a multitarget therapeutic approach. This study presents a novel in silico framework targeting a unique combination of four AD-relevant proteins—sortilin, clusterin, tau,
Nadia Sharif +10 more
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Multitarget drugs: Focus on the NO-donor hybrid drugs [PDF]
Pure and Applied Chemistry, 2008 Abstract The article addresses the design of multitarget drugs, namely, compounds capable of interacting with more than one target simultaneously. These agents could be useful tools in the therapy of complex diseases such as cardiovascular and inflammatory diseases. An interesting case of multitarget compounds are nitric oxide (NO)-donor
Donatella Boschi +2 more
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