Results 11 to 20 of about 9,651 (201)

Drug discovery and computational strategies in the multitarget drugs era [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2018
The pharmaceutical industry is increasingly joining chemoinformatics in the search for the development of new drugs to be used in the treatment of diseases.
Jéssika de Oliveira Viana, Mayara Barbalho Félix, Mayara dos Santos Maia, Vanessa de Lima Serafim, Luciana Scotti, Marcus Tullius Scotti   +5 more
doaj   +3 more sources

Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs [PDF]

Frontiers in Chemistry, 2017
H2S is a gaseous molecule able to trigger a plethora of central physiological and pharmacological effects as antioxidant, pro- and anti-inflammatory, pro- and anti-nociceptive, neuromodulator, and cytoprotective.
Simona Sestito, Giulia Nesi, Rongbiao Pi, Rongbiao Pi, Rongbiao Pi, Marco Macchia, Simona Rapposelli   +6 more
doaj   +2 more sources

Indazolylketones as new multitarget cannabinoid drugs

European Journal of Medicinal Chemistry, 2019
Multitarget cannabinoids could be a promising therapeutic strategic to fight against Alzheimer's disease. In this sense, our group has developed a new family of indazolylketones with multitarget profile including cannabinoids, cholinesterase and BACE-1 activity.
Pedro Gonzalez-Naranjo, Perez Martin, Gabriela Vaca   +2 more
exaly   +4 more sources

Multitarget docking and molecular enumeration reveal DdpMPyPEPhU as a potent modulator of cell cycle, glucocorticoid, and estrogen signalling in breast cancer. [PDF]

PLoS ONE
Breast cancer is one of the most prevalent cancers worldwide, ranked as the second most diagnosed cancer and the fourth leading cause of cancer-related deaths.
Shaban Ahmad, Sahar Qazi, Nagmi Bano, Rahis Uddin, Pramod Kumar Gautam, Khalid Raza   +5 more
doaj   +2 more sources

Polypharmacology of dopamine D1-like receptor antagonists [PDF]

Arhiv za farmaciju, 2015
Drug discovery based on development of selective ligands for a specific target intended to modulate its activity and revert pathophysiological process is now recognized as too simplistic to design effective agent for complex multifactorial diseases ...
Nikolić Katarina, Filipić Slavica, Agbaba Danica   +2 more
doaj   +1 more source

In Silico-Based Design and In Vivo Evaluation of an Anthranilic Acid Derivative as a Multitarget Drug in a Diet-Induced Metabolic Syndrome Model

Pharmaceuticals, 2021
Metabolic syndrome (MetS) is a complex disease that affects almost a quarter of the world’s adult population. In MetS, diabetes, obesity, hyperglycemia, high cholesterol, and high blood pressure are the most common disorders.
Héctor González-Álvarez, Astrid Bravo-Jiménez, Matilda Martínez-Arellanes, Gabriela Odette Gamboa-Osorio, Edwin Chávez-Gutiérrez, Lino A. González-Hernández, Karina Gallardo-Ignacio, Osvaldo J. Quintana-Romero, Armando Ariza-Castolo, Christian Guerra-Araiza, Laura Martino-Roaro, Dulce María Meneses-Ruiz, Rodolfo Pinto-Almazán, Marco A. Loza-Mejía   +13 more
doaj   +1 more source

Multitarget Drug Discovery and Polypharmacology [PDF]

ChemMedChem, 2016
Promising promiscuity: Guest editors Maria Laura Bolognesi and Andrea Cavalli set the stage for this ChemMedChem Special Issue on Polypharmacology and Multitarget Drugs. They highlight cases in which a departure from the "one target, one drug" paradigm has proven advantageous, with single molecules that can engage two or more targets to address a given
BOLOGNESI, MARIA LAURA, CAVALLI, ANDREA
openaire   +3 more sources

Novel Multitarget Therapies for Lung Cancer and Respiratory Disease

Molecules, 2020
In recent years, multitarget drugs for neurological diseases such as Alzheimer’s disease have been developed and well researched. Many studies have revealed that multitarget drugs are also useful for lung cancer and respiratory diseases.
Masako Yumura, Tatsuya Nagano, Yoshihiro Nishimura   +2 more
doaj   +1 more source

Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity

Frontiers in Oncology, 2022
Simultaneous inhibition of more than one target is considered to be a novel strategy in cancer therapy. Owing to the importance of histone deacetylases (HDACs) and p53-murine double minute 2 (MDM2) interaction in tumor development and their synergistic ...
Qian Zhao, Shan-Shan Xiong, Can Chen, Can Chen, Hong-Ping Zhu, Hong-Ping Zhu, Xin Xie, Cheng Peng, Gu He, Bo Han   +9 more
doaj   +1 more source

Extended Multitarget Pharmacology of Anticancer Drugs [PDF]

Journal of Chemical Information and Modeling, 2019
Multitarget pharmacology of small-molecule cancer drugs significantly contributes to their mechanism of action, side effects, and emergence of drug resistance and opens ways to repurpose, combine, or customize drug therapy. In most cases, the set of targets affected at therapeutic concentrations is not fully characterized and/or the interaction ...
Da Shi, Feroz Khan, Ruben Abagyan
openaire   +4 more sources