Results 31 to 40 of about 9,651 (201)
Small and innovative molecules as new strategy to revert MDR
Frontiers in Oncology, 2014 MDR is a complex phenomenon principally due to the overexpression of some transmembrane proteins belonging to the ATP Binding Cassette (ABC) transporter family.
Laura eZinzi +5 more
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Codominant interference, antieffectors, and multitarget drugs [PDF]
Proceedings of the National Academy of Sciences, 1998 The insufficient selectivity of drugs is a bane of present-day therapies. This problem is significant for antibacterial drugs, difficult for antivirals, and utterly unsolved for anticancer drugs, which remain ineffective against major cancers, and in addition cause severe side effects. The problem may be solved if a therapeutic agent could
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Epigenetic polypharmacology: from combination therapy to multitargeted drugs [PDF]
Clinical Epigenetics, 2016 The modern drug discovery process has largely focused its attention in the so-called magic bullets, single chemical entities that exhibit high selectivity and potency for a particular target. This approach was based on the assumption that the deregulation of a protein was causally linked to a disease state, and the pharmacological intervention through ...
de Lera, Angel R., Ganesan, A.
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Systematic Assessment of Fragment Identification for Multitarget Drug Design
ChemMedChem, 2021 AbstractDesigned multitarget ligands are a popular approach to generating efficient and safe drugs, and fragment‐based strategies have been postulated as a versatile avenue to discover multitarget ligand leads. To systematically probe the potential of fragment‐based multiple ligand discovery, we have employed a large fragment library for comprehensive ...
Steffen Brunst +9 more
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Unveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape: A Bibliometric Analysis
Pharmaceuticals, 2022 Multitarget anti-Alzheimer agents are the focus of very intensive research. Through a comprehensive bibliometric analysis of the publications in the period 1990–2020, we have identified trends and potential gaps that might guide future directions.
Anna Sampietro +5 more
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Antioxidants, 2022 Chronic use of glyceryl trinitrate (GTN) is limited by serious side effects, such as tolerance and endothelial dysfunction of coronary and resistance arteries.
Elisabetta Marini +8 more
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Novel paradigms for drug discovery: computational multitarget screening [PDF]
Trends in Pharmacological Sciences, 2008 An established paradigm in current drug development is (i) to identify a single protein target whose inhibition is likely to result in the successful treatment of a disease of interest; (ii) to assay experimentally large libraries of small-molecule compounds in vitro and in vivo to identify promising inhibitors in model systems; and (iii) to determine ...
Ekachai, Jenwitheesuk +4 more
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Integrated systems‐genetic analyses reveal a network target for delaying glioma progression
Annals of Clinical and Translational Neurology, 2019 Objective To identify a convergent, multitarget proliferation characteristic for astrocytoma transformation that could be targeted for therapy discovery.
Liisi Laaniste +15 more
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Multigram Synthesis and in Vivo Efficacy Studies of a Novel Multitarget Anti-Alzheimer’s Compound
Molecules, 2015 We describe the multigram synthesis and in vivo efficacy studies of a donepezil‒huprine hybrid that has been found to display a promising in vitro multitarget profile of interest for the treatment of Alzheimer’s disease (AD).
Irene Sola +16 more
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Pharmaceuticals, 2022 Systemic and pulmonary hypertension are multifactorial, high-pressure diseases. The first one is a civilizational condition, and the second one is characterized by a very high mortality rate. Searching for new therapeutic strategies is still an important
Patryk Remiszewski, Barbara Malinowska
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