Results 51 to 60 of about 9,651 (201)
Brazilian Journal of Psychiatry, 2018 Objective: Anxiety disorders are highly prevalent and the efficacy of the available anxiolytic drugs is less than desired. Adverse effects also compromise patient quality of life and adherence to treatment.
Patrícia Santos +3 more
doaj +1 more source
Molecules, 2021 Diabetes mellitus (DM) represents a group of metabolic disorders that leads to acute and long-term serious complications and is considered a worldwide sanitary emergence.
Massimo Genovese +3 more
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen +10 more
wiley +1 more source
Multi-target drugs: the trend of drug research and development. [PDF]
PLoS ONE, 2012 Summarizing the status of drugs in the market and examining the trend of drug research and development is important in drug discovery. In this study, we compared the drug targets and the market sales of the new molecular entities approved by the U.S ...
Jin-Jian Lu +3 more
doaj +1 more source
Thiosemicarbazone derivatives of transition metals as multi-target drugs: A review
Results in Chemistry, 2022 The mutations of bacteria and viruses along with the resistance of various targets to the existing drugs have emerged as great challenges in the medical field. This imposes the need for novel drugs and medicines to resolve such threats.
Sakshi Gupta +3 more
doaj +1 more source
Asia-Pacific Journal of Chemical Engineering, EarlyView.ABSTRACT To address the persistent exceedance of hydrogen sulfide (H2S) concentrations and the limited effectiveness of existing treatments in the Sickle Bay oil production area, this study deeply analyzes the mechanism of H2S generation in the Sickle Bay oil production area and proposes targeted prevention and control strategies. The results show that
Bo Lei +7 more
wiley +1 more source
Engineered B7‐H3 Binding in Modular Gp2 Miniproteins
Biotechnology and Bioengineering, EarlyView.ABSTRACT B7‐H3, an important immune checkpoint modulator of T‐cell function, is a tumor vasculature biomarker and is overexpressed in a variety of cancers. Its expression is associated with tumor growth, metastasis, and poor clinical prognosis, which makes B7‐H3 an appealing target for diagnostics and therapeutics.
Abbigael Harthorn +5 more
wiley +1 more source
Bulletin of the Korean Chemical Society, EarlyView.Dried blood spot (DBS) analysis enables minimally invasive blood collection with strong analyte stability and simplified logistics, supporting anti‐doping applications beyond traditional matrices. Recent advances address hematocrit, volume variability, and matrix effects while expanding coverage to steroid esters, World Anti‐Doping Agency‐listed ...
Jihyun Yoon +4 more
wiley +1 more source
Enhanced strategies for cuproptosis‐like death in bacterial infection treatment
BMEMat, EarlyView.This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang +7 more
wiley +1 more source
Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs
Molecules, 2020 Diabetes Mellitus (DM) is a multi-factorial chronic health condition that affects a large part of population and according to the World Health Organization (WHO) the number of adults living with diabetes is expected to increase.
Angelica Artasensi +3 more
doaj +1 more source