Results 21 to 30 of about 9,651 (201)
Marine Drugs, 2021 An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AR) enzymes, including analysis of the insulin signalling pathway, of phosphoeleganin, a marine-derived phosphorylated polyketide, was achieved.
Massimo Genovese +8 more
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Molecules, 2022 Although opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common drugs used in persistent pain treatment; they have shown many side effects.
Rita Turnaturi +10 more
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Molecules, 2023 The drug development process suffers from low success rates and requires expensive and time-consuming procedures. The traditional one drug–one target paradigm is often inadequate to treat multifactorial diseases. Multitarget drugs may potentially address
Lu Liu +7 more
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Pharmaceutical Fronts, 2022 Evidence suggested that the use of partial dopamine D2/D3 receptor agonists may be a better choice for the treatment of Parkinson's disease (PD), and the stimulation of 5-HT1A receptors (mainly via nondopaminergic mechanisms) alleviates motor and ...
Xin-Li Du +7 more
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Cells, 2020 In this review we have showcased the preclinical development of original amphiphilic nanomaterials designed for ruthenium-based anticancer treatments, to be placed within the current metallodrugs approach leading over the past decade to advanced ...
Maria Grazia Ferraro +8 more
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Selecting Multitarget Peptides for Alzheimer’s Disease
Biomolecules, 2022 Alzheimer’s disease (AD) is a multifactorial disease with a complex pathogenesis. Developing multitarget drugs could be a powerful strategy to impact the progressive loss of cognitive functions in this disease.
Anne Kasus-Jacobi +3 more
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Antibacterial Drug Leads: DNA and Enzyme Multitargeting [PDF]
Journal of Medicinal Chemistry, 2015 We report the results of an investigation of the activity of a series of amidine and bisamidine compounds against Staphylococcus aureus and Escherichia coli. The most active compounds bound to an AT-rich DNA dodecamer (CGCGAATTCGCG)2 and using DSC were found to increase the melting transition by up to 24 °C.
Wei, Zhu +9 more
openaire +2 more sources
Duloxetine, a Multitarget Drug [PDF]
Advances in Pharmacoepidemiology & Drug Safety, 2012 This review presents an overview of the multi targets of the duloxetine drug which was a product of the famous Eli Lilly Company. Although there is little evidence that the studies reproduce, it is clear that different transmitters or receptor types are involved in hyperalgesia and chronic pain which duloxetine mainly targets.
openaire +1 more source
Disease Pathway Cut for Multi-Target drugs
BMC Bioinformatics, 2019 Background Biomarker discovery studies have been moving the focus from a single target gene to a set of target genes. However, the number of target genes in a drug should be minimum to avoid drug side-effect or toxicity.
Sunjoo Bang +3 more
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Antioxidants, 2020 Alzheimer’s disease is a chronic and irreversible pathological process that has become the most prevalent neurodegenerative disease. Currently, it is considered a multifactorial disease where oxidative stress and chronic neuroinflammation play a crucial ...
Patrycja Michalska +9 more
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