Results 121 to 130 of about 74,680 (298)

Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up

Scientific Reports
We sought to identify long-term associations of medical complications and healthcare utilization related to polypharmacy following spinal surgery for degenerative lumbar pathology.
Nicholas Dietz, Chitra Kumar, Aladine A. Elsamadicy, Martin F. Bjurström, Katrina Wong, Alysha Jamieson, Mayur Sharma, Dengzhi Wang, Beatrice Ugiliweneza, Doniel Drazin, Maxwell Boakye   +10 more
doaj   +1 more source

Medication Prescribing Patterns for Chronic Kidney Diseases: Analysis of Drug-Dose Adjustments, Polypharmacy, and Drug Interactions

Background: Multiple drug prescriptions in chronic kidney disease (CKD) escalate metabolic buildup, nephrotoxicity, and end stage kidney disease progression.
Ikilas Moldaliyev, Rita Assabayeva, Meruyert Madikenova, Dmitriy Sychev, Ali Issayev, Dmitriy Syssoyev, Aizat Seidakhmetova, Ainur Assan, Zakira Kerimbayeva, Abduzhappar Gaipov   +9 more
core   +1 more source

Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science

Clinical Pharmacology &Therapeutics, EarlyView.
New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS).
Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi, Jahan Cooper, Tromondae K. Feaster, Paula L. Hyland, Lidiya Stavitskaya, Wendy W. Wu, Jeffry Florian, Rodney Rouse   +9 more
wiley   +1 more source

An observational cross-sectional study on the impact of polypharmacy on medication adherence in patients with type 2 diabetes mellitus.

Student's Journal of Health Research Africa
Background: Polypharmacy is increasingly prevalent among patients with Type 2 Diabetes Mellitus (T2DM) due to frequent comorbidities. While multiple medications may be clinically justified, their cumulative burden can impair adherence, ultimately ...
Dr. Gayathri Elango, Dr. Athira Muralidas, Dr. Prasheeta V Praviraj   +2 more
doaj   +1 more source

Incident heart failure: comparing management and outcome in primary and hospital settings in Western Sweden 2008–2017

ESC Heart Failure, Volume 12, Issue 2, Page 832-838, April 2025.
Abstract Aim Heart failure (HF) is a highly prevalent condition managed in both primary care (PC) and hospital care (HC)‐based settings. HF patients managed in these two settings may differ in their demography, comorbidities and outcomes, so we aimed to compare the patient management in PC and HC in the Västra Götaland Region (VGR) in Sweden.
Xiaojing Chen, Aldina Pivodic, Maria Schaufelberger, Annika Rosengren, Michael Fu   +4 more
wiley   +1 more source

Polypharmacy in the Older Adult

, 2016
Discuss the definitions of polypharmacy Describe factors associated with polypharmacy Discuss the prevalence of polypharmacy Describe the consequences of polypharmacy Discuss strategies to address polypharmacy Presentation: 40 ...
Shah, PharmD, BCPS, AAHIVP, Bhavik M.
core   +1 more source

Polypharmacy in Older Adults

, 2015
Polypharmacy, by definition, is the concurrent use of several different medications consumed by a person. Often these multiple medications are in the same class and are used to treat more than one chronic condition. Older individuals are often faced with
Patricia T. Alpert, Alpert, Patricia T, Gatlin, Patricia K, Tricia Gatlin   +3 more
core   +1 more source

Polypharmacy and adverse drug reactions in Japanese elderly taking antihypertensives: a retrospective database study

, 2013
Izumi Sato,1 Manabu Akazawa21Department of Epidemiology and Statistics, Graduate School of Medicine, The University of Tokyo Tokyo, Japan; 2Department of Public Health and Epidemiology, Meiji Pharmaceutical University, Tokyo, JapanBackground: The ...
Sato I, Akazawa M
core  

Phenotyping patients with chronic obstructive pulmonary disease and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 900-911, April 2025.
Central illustration. Abbreviations: ACEi, angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNi, angiotensin‐receptor‐neprilysin inhibitor; CI, confidence interval; COPD, chronic obstructive pulmonary disease; CRT, cardiac resynchronization therapy; CV, cardiovascular; EF, ejection fraction; eGFR, estimated glomerular ...
Peter Moritz Becher, Felix Lindberg, Lina Benson, Camilla Hage, Ulf Dahlström, Stephan Rosenkranz, Francesco Cosentino, Giuseppe M.C. Rosano, Stefan Blankenberg, Paulus Kirchhof, Frieder Braunschweig, Lars H. Lund, Gianluigi Savarese   +12 more
wiley   +1 more source

Spotlight commentary: Addressing the persistent problem of benzodiazepine overuse, time for clinical, educational and AI‐driven reform

British Journal of Clinical Pharmacology, EarlyView.
Jakša Vukojević, Luka Horvat, Vito Papić, Andrija Štajduhar   +3 more
wiley   +1 more source