Results 41 to 50 of about 10,628 (244)

Polyphosphate Is a Primordial Chaperone [PDF]

Molecular Cell, 2014
Composed of up to 1,000 phospho-anhydride bond-linked phosphate monomers, inorganic polyphosphate (polyP) is one of the most ancient, conserved, and enigmatic molecules in biology. Here we demonstrate that polyP functions as a hitherto unrecognized chaperone.
Gray, Michael J., Wholey, Wei-Yun, Wagner, Nico O., Cremers, Claudia M., Mueller-Schickert, Antje, Hock, Nathaniel T., Krieger, Adam G., Smith, Erica M., Bender, Robert A., Bardwell, James C.A., Jakob, Ursula   +10 more
openaire   +2 more sources

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Polyphosphate strikes back [PDF]

Blood, 2016
In this issue of Blood, Mitchell et al show how platelet polyphosphate (polyP) amplifies the role of factor XII (FXII) as a plasminogen activator. This negatively charged polymer acts as a “molecular adaptor” that concentrates FXII and plasminogen on the surface of fibrin polymers, eventually resulting in plasmin formation (see figure ...
openaire   +2 more sources

Vtc5 Is Localized to the Vacuole Membrane by the Conserved AP-3 Complex to Regulate Polyphosphate Synthesis in Budding Yeast

mBio, 2021
Long polymers of inorganic phosphates called polyphosphates are ubiquitous across biological kingdoms. From bacteria to humans, they have diverse functions related to protein homeostasis, energy metabolism, and cell signaling.
Amanda Bentley-DeSousa, Michael Downey
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Antibacterial effects of commercially available phosphates on selected microorganisms

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2008
In the food industry, phosphates, polyphosphates and their salts are used, for example, as emul­si­fying agents in the production of processed cheese.
Leona Buňková, Pavel Pleva, František Buňka, Pavel Valášek, Stanislav Kráčmar   +4 more
doaj   +1 more source

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase

Molecules, 2021
IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao, Ruth Manorama, Shubhra Ganguli, Mithun C. Madhusudhanan, Rashna Bhandari, Kana M. Sureshan   +5 more
doaj   +1 more source

Crystal structure of a polyphosphate kinase and its implications for polyphosphate synthesis [PDF]

The EMBO Reports, 2005
Polyphosphate (polyP), a linear polymer of hundreds of orthophosphate residues, exists in all tested cells in nature, from pathogenic bacteria to mammals. In bacteria, polyP has a crucial role in stress responses and stationary-phase survival. Polyphosphate kinase (PPK) is the principal enzyme that catalyses the synthesis of polyP in bacteria.
Ye, Zhu, Weijun, Huang, Sam S K, Lee, Wenqing, Xu   +3 more
openaire   +2 more sources