Results 91 to 100 of about 182 (128)

Simultaneous determination and pharmacokinetic study of polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII in beagle dog plasma after oral administration of Rhizoma Paridis extracts by LC‐MS‐MS

Biomedical Chromatography, 2012
ABSTRACTFor the first time, a rapid and specific LC‐MS‐MS method has been developed for the analysis of polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII in beagle dog plasma. The method was applied to study the pharmacokinetics of Rhizoma Paridis extracts containing polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII. The
Xingbin, Yin, Changhai, Qu, Zhaoxia, Li, Yujing, Zhai, Sali, Cao, Longfei, Lin, Lijun, Feng, Lei, Yan, Jian, Ni   +8 more
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An improved synthesis of the saponin, polyphyllin D

Carbohydrate Research, 2001
Polyphyllin D, namely diosgenyl alpha-L-rhamnopyranosyl-(1 --> 2)- [(alpha-L-arabinofuranosyl)-(1 --> 4)]-[beta-D-glucopyranoside, was synthesized from diosgenyl-beta-D-glucopyranoside in four steps and in 30% overall yield, taking advantage of regioselective pivaloylation and alpha-L-rhamnopyranosylation reactions.
B, Li, B, Yu, Y, Hui, M, Li, X, Han, K P, Fung   +5 more
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Polyphyllin I, a strong antifungal compound against Candida albicans

APMIS, 2023
This study was performed to explore the antifungal and antibiofilm effects of polyphyllin I (PPI) on Candida albicans. Microdilution assay was performed to determine the minimal inhibitory concentrations (MIC) of PPI against Candida species. Adhesion assay, hyphal growth assay, biofilm formation, and development were used to test the impacts of PPI on ...
Yu Zhang, Jingxiao Zhang, Jian Sun, Min Zhang, Xin Liu, Longfei Yang, Yongjie Yin   +6 more
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[Study on hemolytic mechanism of polyphyllin II].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2016
To study the hemolytic effect of polyphyllin II (PP II) mediated by anion channel protein and glucose transporter 1 (GLUT1), in order to initially reveal its hemolytic mechanism in vitro. In the experiment, the spectrophotometric method was adopted to detect the hemolysis of PP II in vitro and the effect of anion channel-related solution and blocker ...
Li-hua, Ning, Bo, Zhou, Yao-xiang, Zhang, Xin-ping, Li   +3 more
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Anti-cancer effects of Polyphyllin I: An update in 5 years

Chemico-Biological Interactions, 2020
Chong-lou, the rhizome of Paris polyphylla, has been used in herbal regimes to treat parotitis, mastitis and certain malignant tumors for thousands of years in traditional medicine. Polyphyllin I (PPI) is the main bioactive component in Paris polyphylla. Recent studies of PPI in various types of cancers have shown that PPI may exert a broad spectrum of
Ye, Tian, Guan-Yu, Gong, Liang-Liang, Ma, Zhuo-Qun, Wang, Dan, Song, Mei-Yun, Fang   +5 more
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Fluorophore-Appended Steroidal Saponin (Dioscin and Polyphyllin D) Derivatives

Organic Letters, 2005
The synthesis of three fluorophore-appended derivatives of dioscin and polyphyllin D is reported herein. Starting from trillin, dansyl derivatives A-C were prepared in overall yields of 7-12% over 7-10 steps. A study of their behavior in a variety of polar solvents suggests that dansyl derivatives A-C are capable of micellar self-assembly and can ...
Che, CM, Wong, ELM, Shum, TYT, Hui, Y, Yang, Z   +4 more
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Polyphyllin VII induces fibroblasts apoptosis via the ERK/JNK pathway

Burns, 2021
Hypertrophic scar (HS) is a pathological scar that often occurs in burn patients. Its histology is characterized by the excessive proliferation of fibroblasts (FB) and excessive accumulation of extracellular matrix (ECM). Inhibition of proliferation and activation of FB is essential for the treatment of HS.
Chaoyi, Zhong, Qingwen, Nong, Wenyu, Feng, Yugu, Pan, Yajun, Wu, Xianmin, Zeng, Hanwen, Li, Xueran, Zhong, Feicui, Li, Zhiwei, Luan, Xing, Huang, Kai, Luo, Daen, Liu, Jun, Yao   +13 more
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ChemInform Abstract: An Improved Synthesis of the Saponin, Polyphyllin D.

ChemInform, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bing Li, Biao Yu, Yongzheng Hui, Ming Li, Xiuwen Han, Kwok‐Pui Fung   +5 more
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Polyphyllin VII is a Potential Drug Targeting CD44 Positive Colon Cancer Cells

Current Cancer Drug Targets, 2022
Background: Current therapies for colon cancer are hindered by treatment failure and recurrence, mainly due to colon cancer stem cells (CSCs). Thus, treatment using drugs targeting CSCs should be effective in eliminating colon cancer cells and impeding cancer recurrence. Objective: This study aimed to test if PPVII can be a potent drug candidate for
Ye, Zhu, Fei, Fu, Zhongyu, Wang, Fen, Qiu, Ting, Deng, Boyu, Du, Yunhe, Zhu, Xueyan, Xi   +7 more
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Polyphyllin I in malignant tumors: molecular mechanisms and advances

Phytomedicine
Natural products derived from traditional Chinese medicine have become an important focus in anticancer drug discovery due to their favorable safety profiles and multi-target properties. Polyphyllin I (PPI), a major bioactive constituent of Rhizoma Paridis (Chong-lou), represents the key pharmacological basis for its traditional uses, including heat ...
Yiyan Zhai, Xiangli Yin, Zeyu Xue, Zijian Xu, Huiling Lei, Peiying Lu, Xiaodong Chen, Meiling Guo, Junyi Li, Muyassar Mamattohti, Xiaojing Zhao, Chunguo Wang, Jiarui Wu   +12 more
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