Results 101 to 110 of about 182 (128)
Some of the next articles are maybe not open access.
Polyphyllin D induces apoptosis and differentiation in K562 human leukemia cells
International Immunopharmacology, 2016Polyphyllin D, a compound derived from Paris polyphylla rhizoma, demonstrated strong anticancer activities in a previous study. Our results demonstrated that polyphyllin D exerts a growth inhibitory effect by inducing apoptosis and differentiation in the human erythroleukemia cell line K562.
Chunhui, Yang, Hong, Cai, Xiuxiang, Meng
openaire +2 more sources
Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells
Cancer Letters, 2005In a search for new anticancer agents, we identified a novel compound polyphyllin D (PD) (diosgenyl alpha-L-rhamnopyranosyl-(1-->2)-(alpha-L-arabinofuranosyl)-(1-->4)]-[beta-D-glucopyranoside) that induced DNA fragmentation and phosphatidyl-serine (PS) externalization in a hepatocellular carcinoma cell line HepG2 derivative with drug resistance (R ...
Jenny Yuen-Nei, Cheung +8 more
openaire +2 more sources
Polyphyllin VI: A promising treatment for prostate cancer bone metastasis
International ImmunopharmacologyProstate cancer, as one of the most prevalent malignant tumors in men, seriously affects the prognosis and survival of patients due to its extremely high rate of bone metastasis. This study investigated the effect of Polyphyllin VI (PPVI) on metastatic bone disease for the first time in prostate cancer, focusing on its impact on osteoclast and tumor ...
Yanbin, Feng +7 more
openaire +2 more sources
Synthesis of three diosgenyl saponins: dioscin, polyphyllin D, and balanitin 7
Carbohydrate Research, 1999Dioscin, polyphyllin D, and balanitin 7, which belong to a group of structurally similar diosgenyl saponins with promising bioactivities, were synthesized by stepwise glycosylation.
S, Deng, B, Yu, Y, Hui, H, Yu, X, Han
openaire +2 more sources
A synergistic antitumor effect of polyphyllin I and formosanin C on hepatocarcinoma cells
Bioorganic & Medicinal Chemistry Letters, 2016Polyphyllin I (PPI) and formosanin C (FC) were regarded as effective and imperative components isolated from Rhizoma Paridis saponins (RPS) and exhibited strong anti-tumor effects on a variety of cancers. With the wide application of complex mixtures in clinics, synergistic interactions are of vital importance in phytomedicine.
Jing Liu +4 more
openaire +2 more sources
Two rhamnosyltransferases for de novo biosynthesis of polyphyllins in Nicotiana benthamiana
The Plant JournalSUMMARYPolyphyllins, a prominent class of steroidal saponins in Paris species, owe their diverse bioactivities to their sugar unit configurations, though their glycosylation pathways remain poorly understood. Here, we identified and characterized two UDP‐rhamnosyltransferases, PpUGT73YD1 and PpUGT738A2, using heterologous expression systems.
Wei Song +7 more
openaire +2 more sources
Polyphyllin I in Malignant Tumors: Molecular Mechanisms and Recent Advances
BackgroundRhizoma Paridis (Chong-lou) is a widely used traditional Chinese medicine known for its effects in reducing swelling, relieving pain, and clearing heat and toxins. Modern pharmacological studies have confirmed that it possesses antibacterial, anti-inflammatory, analgesic, anticancer, and immunoregulatory properties.Yiyan Zhai +12 more
openaire +1 more source
Structure‐Driven Mechanisms and Synergistic Approaches of Polyphyllin VII in Breast Cancer Therapy
Archiv der PharmazieABSTRACT Polyphyllin VII (PP7), a natural saponin derived from the rhizomes of Paris polyphylla (family: Melanthiaceae), possesses a unique steroidal furostane structure that contributes to its versatile pharmacological profile.
Alaa O. Hamouda +5 more
openaire +2 more sources