Results 1 to 10 of about 1,357 (186)

Compartment-Specific Variation in Bacterial Microbiome and Polyphyllin Profiles in Paris polyphylla [PDF]

International Journal of Microbiology
Paris polyphylla (P. polyphylla) is a valuable traditional Chinese medicinal plant, yet the spatial distribution of its compartment-specific bacterial microbiomes and their correlative relationships with bioactive polyphyllins remain poorly characterized.
Xinhong Wu, Yan Deng, Shihui Li, Kai Zou, Zhenchun Duan, Nazidi Ibrahim, Jin Zhou, Luhua Jiang, Xueduan Liu, Shaodong Fu, Yili Liang   +10 more
doaj   +6 more sources

Dissection of transcriptome and metabolome insights into the polyphyllin biosynthesis in Paris [PDF]

BMC Plant Biology
Background Polyphyllins are significant medicinal compounds found in Paris species, with different polyphyllins fulfilling distinct medicinal roles. Although some genes involved in polyphyllin synthesis have been identified, further exploration of the ...
Ping Xu, Qi Mi, Xiaoye Zhang, Xuan Zhang, Mengwen Yu, Yingsi Gao, Xiheng Wan, Yichun Chen, Qiaoyuan Li, Jia Chen, Guowei Zheng   +10 more
doaj   +5 more sources

The Interaction Between Polyphyllin I and SQLE Protein Induces Hepatotoxicity Through SREBP-2/HMGCR/SQLE/LSS Pathway

Journal of Pharmaceutical Analysis, 2023
Polyphyllin I (PPI) and polyphyllin II (PII) are the main active substances in the Paris polyphylla. However, liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated. In
Xianwen Ye, Fan Qiqi
exaly   +4 more sources

Exploration of the mechanism of Polyphyllin I against hepatocellular carcinoma based on network pharmacology, molecular docking and experimental validation [PDF]

Discover Oncology
Purpose Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Targeted therapies hold promise for HCC treatment, and understanding the molecular mechanisms of action is crucial for developing novel therapeutic strategies ...
Yilong Chen, Qiuying Wang, Shuixiu Bian, Jing Dong, Jie Xiong, Jiamei Le   +5 more
doaj   +3 more sources

Polyphyllin B induces ferroptosis in triple-negative breast cancer by inactivating NRF2 [PDF]

Frontiers in Pharmacology
BackgroundTriple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC) and lacks effective treatment options. Polyphyllin B (PB), a saponin extracted from Paris formosana Hayata, has shown potential in cancer therapy. However,
Ping Deng, Shouhai Zhu, Yuxuan Wu, Zhiju Fang, Aini Zhang, Dongyi Zhang, Xiaoqu Hu, Xiang Zhou   +7 more
doaj   +4 more sources

Polyphyllin II inhibits thyroid cancer cell growth by simultaneously inhibiting glycolysis and oxidative phosphorylation [PDF]

Open Medicine
Thyroid cancer is the most common malignancy of the endocrine system, and effective treatments for metastatic disease are still lacking. Targeting both glycolysis and oxidative phosphorylation (OXPHOS) simultaneously represents a novel approach to cancer
Sun Jianwei, Ding Ding, Xiang Qian, Zheng Mengyang, Dai Mingming   +4 more
doaj   +2 more sources

The Mechanisms of Ramulus Cinnamomi and Rhizoma Paridis in Gynecological Cancers: A Narrative Review [PDF]

Cancer Management and Research
Feng Li,1 Weipin Niu,2 Wei Shi31First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250014, People’s Republic of China; 2Laboratory Center, Shandong University of Traditional Chinese Medicine Affiliated Hospital ...
Li F, Niu W, Shi W
doaj   +2 more sources

The influence of intercropping Paris polyphylla with Polygonatum cyrtonema or Ganoderma lucidum on rhizosphere soil microbial community structure and quality of Paris polyphylla [PDF]

Frontiers in Microbiology
IntroductionProlonged monoculture cultivation of Paris polyphylla has been linked to challenges such as disruption of rhizosphere soil microbial balance and deterioration in crop quality.
Hailan Su, Penghui Liao, Hong Chen, Fengfang Lin, Meixia Zheng, Yuqing Niu, Wei Ye, Fanghua Mao, Yujing Zhu, Yanghui Fang, Yanming Zhu   +10 more
doaj   +2 more sources

AI-identified CD133-targeting natural compounds demonstrate differential anti-tumor effects and mechanisms in pan-cancer models [PDF]

EMBO Molecular Medicine
Advanced algorithms have significantly improved the efficiency of in vitro screening for protein-interactive compounds. However, target antigen (TAA/TSA)-based drug discovery remains challenging, as predictions of compound-protein interaction (CPI) based
Yibo Hou, Zixian Wang, Wenlin Wang, Qing Tang, Yongde Cai, Siyang Yu, Jin Wang, Xiu Yan, Guocai Wang, Peter E Lobie, Yubo Zhang, Xiaoyong Dai, Shaohua Ma   +12 more
doaj   +2 more sources

Polyphyllins ameliorate imiquimod-induced psoriatic skin barrier disruption and lesions in mice by inhibiting inflammatory infiltration with accelerated recovery effects [PDF]

Frontiers in Immunology
BackgroundPsoriasis is a chronic inflammatory skin disorder that significantly compromises patients’ quality of life. While dexamethasone (DEX) is effective as a first-line treatment, its adverse effects highlight the need for alternatives.
Siqi Ren, Siqi Ren, Yang Yang, Huiwen Zhang, Jingmin Tian, Xiao Li, Ying Zhang, Wuzhou Wan, Ping Li, Jiannan Ma, Jianye Wang, Qianghua Quan   +11 more
doaj   +2 more sources