Results 1 to 10 of about 22,479,757 (178)

The Interaction Between Polyphyllin I and SQLE Protein Induces Hepatotoxicity Through SREBP-2/HMGCR/SQLE/LSS Pathway [PDF]

Journal of Pharmaceutical Analysis, 2023
Polyphyllin I (PPI) and polyphyllin II (PII) are the main active substances in the Paris polyphylla. However, liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated. In
Xianwen Ye, Fan Qiqi
exaly   +5 more sources

Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis [PDF]

Frontiers in Pharmacology, 2023
Background: Ferroptosis is a new form of regulated cell death characterized by the accumulation of iron-dependent lipid peroxides and membrane damages. Recent studies have identified an important role for cancer cell ferroptosis in antitumor therapy.
Fang Zheng, Fang Zheng, Yeshu Wang, Qunfang Zhang, Qunfang Zhang, Qiuyuan Chen, Chun-Ling Liang, Huazhen Liu, Feifei Qiu, Yuchao Chen, Haiding Huang, Haiding Huang, Weihui Lu, Weihui Lu, Zhenhua Dai, Zhenhua Dai   +15 more
doaj   +6 more sources

Compartment-Specific Variation in Bacterial Microbiome and Polyphyllin Profiles in Paris polyphylla [PDF]

International Journal of Microbiology
Paris polyphylla (P. polyphylla) is a valuable traditional Chinese medicinal plant, yet the spatial distribution of its compartment-specific bacterial microbiomes and their correlative relationships with bioactive polyphyllins remain poorly characterized.
Xinhong Wu, Yan Deng, Shihui Li, Kai Zou, Zhenchun Duan, Nazidi Ibrahim, Jin Zhou, Luhua Jiang, Xueduan Liu, Shaodong Fu, Yili Liang   +10 more
doaj   +6 more sources

Exploration of the mechanism of Polyphyllin I against hepatocellular carcinoma based on network pharmacology, molecular docking and experimental validation [PDF]

Discover Oncology
Purpose Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Targeted therapies hold promise for HCC treatment, and understanding the molecular mechanisms of action is crucial for developing novel therapeutic strategies ...
Yilong Chen, Qiuying Wang, Shuixiu Bian, Jing Dong, Jie Xiong, Jiamei Le   +5 more
doaj   +3 more sources

Polyphyllin I alleviates neuroinflammation after cerebral ischemia–reperfusion injury via facilitating autophagy-mediated M2 microglial polarization [PDF]

Molecular Medicine
Microglial activation and polarization play a central role in poststroke inflammation and neuronal damage. Modulating microglial polarization from pro-inflammatory to anti-inflammatory phenotype is a promising therapeutic strategy for the treatment of ...
Chunyang Kang, Qiuling Sang, Dingxi Liu, Libo Wang, Jia Li, Xiaoyang Liu   +5 more
doaj   +3 more sources

Polyphyllin I exerts anti-hepatocellular carcinoma activity by targeting ZBTB16 to activate the PPARγ/RXRα signaling pathway [PDF]

Chinese Medicine
Background Studies have reported that polyphyllin I (PPI) had effective anti-tumor activity against hepatocellular carcinoma (HCC). However, the precise molecular mechanism of this action and the direct target remain unclear. The aim of this study was to
Lu shan, Yijun Chen, Guo An, Xiaoyu Tao, Chuanqi Qiao, Meilin Chen, Jiaqi Li, Ruichao Lin, Jiarui Wu, Chongjun Zhao   +9 more
doaj   +4 more sources

MiR-124-3p mediates gastric cancer cell ferroptosis induced by an anti-cancer drug polyphyllin I [PDF]

Frontiers in Pharmacology, 2023
Background: Ferroptosis is an emerging type of regulated cell death and associated with antitumoral therapy, while some microRNAs have been shown to regulate the tumorigenesis and cancer progression.
Fang Zheng, Jian-Can Bi, Yu-Yan Wei, Yeshu Wang, Qunfang Zhang, Chun-Ling Liang, Jianwei Wu, Zhenhua Dai   +7 more
doaj   +2 more sources

Polyphyllin I suppressed the apoptosis of intervertebral disc nucleus pulposus cells induced by IL-1β by miR-503-5p/Bcl-2 axis [PDF]

Journal of Orthopaedic Surgery and Research, 2023
Background There are no studies that have shown the role and underlying mechanism of Polyphyllin I (PPI)-mediated anti-apoptosis activity in nucleus pulposus cells (NPCs).
Lei Yuan, Hui Miao, Heng Ding, Fan Zhang, Zhen-kai Lou, Xing-Guo Li   +5 more
doaj   +2 more sources

Antitumor effect of polyphyllin I (PPI) on colorectal cancer: Evidence from patient-derived organoids and Notch signaling suppression [PDF]

Heliyon
Colorectal cancer (CRC) is a malignant tumor with a high incidence, ranking first among gastrointestinal malignancies. We investigated the impact of polyphyllin I (PPI), a natural compound found in Paris polyphylla, on CRC.
Yu Wang, Hao Ge, Yi Zhang, Pei Wang, Haoran Zhao, Lu Wang, Zhimin Fan   +6 more
doaj   +2 more sources

The Mechanisms of Ramulus Cinnamomi and Rhizoma Paridis in Gynecological Cancers: A Narrative Review [PDF]

Cancer Management and Research
Feng Li,1 Weipin Niu,2 Wei Shi31First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250014, People’s Republic of China; 2Laboratory Center, Shandong University of Traditional Chinese Medicine Affiliated Hospital ...
Li F, Niu W, Shi W
doaj   +2 more sources