Diversity, 2022 Paris polyphylla Smith is a perennial medicinal herb with records from around 2000 years ago. Polyphyllins are the main bioactive compounds of this herb, which are found to have remarkable effects on bacteriostatic, antiphlogistic, sedative, and ...
Qixuan Su +6 more
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Synergistic anticancer effects of polyphyllin I and evodiamine on freshly-removed human gastric tumors. [PDF]
PLoS ONE, 2013 The present study was designed to examine the anticancer effect of Traditional Chinese Medicine of polyphyllin I (PPI) and evodiamine (EVO) on freshly-removed gastric tumor tissues.Sixty freshly-removed gastric tumor tissues were collected.
Guofeng Yue +8 more
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Corrigendum: Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis [PDF]
Frontiers in Pharmacology, 2023 Fang Zheng +15 more
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Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway [PDF]
Frontiers in Immunology, 2018 Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder, characterized by an increased number of M1-like macrophages in the joints. Polyphyllin I (PPI), one of the main components in the Rhizoma of Paris polyphyllin, displays a selective ...
Qiong Wang +19 more
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Polyphyllin I Inhibits the Metastasis of Cervical Cancer Through the Regulation of the β-Catenin Signaling Pathway. [PDF]
Int J Mol SciCervical cancer ranks as the fourth most prevalent cancer and cause of cancer-related mortality among women globally. It exhibits a recurrence/metastasis rate of approximately 30% and a dismal 5-year survival of only 17% in metastatic cases. Despite significant advancements in surgical techniques, chemoradiotherapy, and targeted therapies, effective ...
Chai Y +8 more
europepmc +4 more sources
Polyphyllin I suppresses human osteosarcoma growth by inactivation of Wnt/β-catenin pathway in vitro and in vivo [PDF]
Scientific Reports, 2017 Osteosarcoma is the most common primary bone cancer in children and adolescents. In spite of aggressive treatment, osteosarcoma has a high mortality rate with minimal improvements in survival over past few decades. Polyphyllin I (PPI), a component in the
Junli Chang +7 more
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Retraction Note: Polyphyllin I suppresses the formation of vasculogenic mimicry via Twist1/VE-cadherin pathway [PDF]
Cell Death and DiseaseTing Xiao +16 more
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Molecules, 2022 An effective method for separating and purifying critical saponins (polyphyllin II and polyphyllin VII) from a Paris polyphylla var. yunnanensis extract was developed in this study which was environmentally friendly and economical.
Xiaoya Zhang +7 more
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Dissection of transcriptome and metabolome insights into the polyphyllin biosynthesis in Paris
BMC Plant BiologyBackground Polyphyllins are significant medicinal compounds found in Paris species, with different polyphyllins fulfilling distinct medicinal roles. Although some genes involved in polyphyllin synthesis have been identified, further exploration of the ...
Ping Xu +10 more
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Natural Product Research, 2023 Previous research has indicated that Polyphyllin I (PPI) possesses potent anticancer properties. However, its impact on endometriosis remains unexplored. This study aims to investigate the inhibitory effects of PPI on ectopic endometrial stromal cells (EESCs).
Liping, Li +5 more
openaire +3 more sources