Results 21 to 30 of about 22,479,757 (178)

Polyphyllin B inhibited STAT3/NCOA4 pathway and restored gut microbiota to ameliorate lung tissue injury in cigarette smoke-induced mice

BMC Biotechnology
Objective Smoking was a major risk factor for chronic obstructive pulmonary disease (COPD). This study plan to explore the mechanism of Polyphyllin B in lung injury induced by cigarette smoke (CSE) in COPD.
Qing Wang, Zhiyi He, Jinqi Zhu, Mengyun Hu, Liu Yang, Hongzhong Yang   +5 more
doaj   +2 more sources

Functional metal–organic framework nanoparticles loaded with polyphyllin I for targeted tumor therapy

Journal of Science: Advanced Materials and Devices, 2023
Polyphyllin I (PPI) is a naturally active steroidal saponin that has good therapeutic effects in various cancers, such as liver and lung cancers. However, owing to its non-selective distribution in various tissues, it is toxic and has side effects on ...
Kaixin Wang, Mengru Cai, Dongge Yin, Rongyue Zhu, Tingting Fu, Shilang Liao, Yuji Du, Jiahui Kong, Jian Ni, Xingbin Yin   +9 more
doaj   +2 more sources

Polyphyllin I Effects Candida albicans via Inhibition of Virulence Factors. [PDF]

Evid Based Complement Alternat Med, 2023
Paris polyphylla is often used in Chinese medicine to treat conditions such as carbuncles, trauma, snake bites, and mosquito bites. In the present study, we investigated the effect and mechanism of the morphological transition and extracellular phospholipase activity of Candida albicans treated with polyphyllin I (PPI).
Sun AM, Wang YX, Hu GX, Li L, Wang RR.
europepmc   +3 more sources

Discrimination of wild Paris based on near infrared spectroscopy and high performance liquid chromatography combined with multivariate analysis.

PLoS ONE, 2014
Different geographical origins and species of Paris obtained from southwestern China were discriminated by near infrared (NIR) spectroscopy and high performance liquid chromatography (HPLC) combined with multivariate analysis.
Yanli Zhao, Ji Zhang, Tianjun Yuan, Tao Shen, Wei Li, Shihua Yang, Ying Hou, Yuanzhong Wang, Hang Jin   +8 more
doaj   +2 more sources

Response Surface Optimization for Water-Assisted Extraction of Two Saponins from Paris polyphylla var. yunnanensis Leaves

Molecules
The process of extracting polyphyllin II and polyphyllin VII by water-assisted extraction was established and optimized in this study. Response surface methodology was used to establish a prediction model to optimize the extraction conditions.
Yutian Jin, Qing Qiao, Linmei Dong, Mokun Cao, Ping Li, Aizhong Liu, Rui Sun   +6 more
doaj   +2 more sources

Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells. [PDF]

PLoS ONE, 2016
Polyphyllin VII (PP7), a pennogenyl saponin isolated from Rhizoma Paridis, exhibited strong anticancer activities in various cancer types. Previous studies found that PP7 induced apoptotic cell death in human hepatoblastoma cancer (HepG2) cells.
Chao Zhang, Xuejing Jia, Kai Wang, Jiaolin Bao, Peng Li, Meiwan Chen, Jian-Bo Wan, Huanxing Su, Zhinan Mei, Chengwei He   +9 more
doaj   +2 more sources

Polyphyllin H Reverses Paclitaxel Resistance in Breast Cancer by Binding Membrane Cholesterol to Inhibit Both ABCB1 and ABCC3

Pharmaceuticals
Background/Objectives: Breast cancer is the most prevalent malignancy among women, and paclitaxel (PTX) is a first-line chemotherapeutic, but chemoresistance driven by ATP-binding cassette (ABC) transporters limits its efficacy.
Zheng Ye, Chao Hong, Min Jiang, Wenkui Zou, Yaning Ren, Mingfang Li, Xinyue Xue, Xiaoting Xie, Tong Zhang, Yue Ding   +9 more
doaj   +2 more sources

Composition Study of Polyphyllin in Paris polyphylla by Ultrasound-Assisted Deep Eutectic Solvent Extraction Combined with UHPLC-MS/MS [PDF]

Molecules
Paris polyphylla (Chonglou), a medicinal herb documented in Shennong’s Classic of Materia Medica and a key component of formulas such as Yunnan Baiyao, is a rare and endangered plant prized for its bioactive steroidal saponins, notably polyphyllin I (PPI)
Jinyu Guo, Jiajia Liu, Minlong Li, Zhenlin Tan, Huayin Lu, Yuting Zhou   +5 more
doaj   +2 more sources

The protective effect of polyphyllin I on myocardial ischemia/reperfusion injury in rats. [PDF]

Ann Transl Med, 2020
Myocardial ischemia/reperfusion (I/R) injury has become a global public health concern. An increasing amount of evidence has shown that polyphyllin I (PPI) has anti-apoptotic and antioxidant functions. This study was performed to evaluate the cardioprotective effects of PPI in a rat model of myocardial I/R injury and the underlying mechanism.We exposed
Huang R, Shu J, Dai X, Liu Y, Yu F, Shi G.   +5 more
europepmc   +3 more sources

The biosynthesis of trillin 6′-O-glucoside: A low-abundance yet pharmacologically active polyphyllin from Paris polyphylla

Synthetic and Systems Biotechnology
Natural products from medicinal plants serve as an invaluable resource for drug discovery and development. However, low-abundance natural products are often understudied due to the challenges of obtaining sufficient quantities for pharmacological testing
Yaran Suo, Shuyu Li, Haining Lyu, Xin Zhao, Jiale Xing, Xin Chai, Qian Zhang, Chunjin Fu, Chengchao Xu, Jingjing Liao   +9 more
doaj   +2 more sources