Disruption of Colorectal Cancer Network by Polyphyllins Reveals Pivotal Entities With Implications for Chemoimmunotherapy [PDF]
Biomedicines, 2022 The prevalence of colorectal cancer has increased world-wide with high rates of mortality and morbidity. In the absence of efficacious drugs to treat this neoplasia, there is an imminent need to discover molecules with multifaceted effects.
Ramamurthy Siripuram +2 more
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Dissection of Transcriptome and Metabolome Insights Into the Polyphyllin Biosynthesis in Paris [PDF]
BMC Plant BiologyBackground Polyphyllins are significant medicinal compounds found in Paris species, with different polyphyllins fulfilling distinct medicinal roles. Although some genes involved in polyphyllin synthesis have been identified, further exploration of the ...
Guowei Zheng, Yingsi Gao, Xiheng Wan
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Effective Prediction of Biosynthetic Pathway Genes Involved in Bioactive Polyphyllins in Paris polyphylla [PDF]
Communications Biology, 2022 Xin Hua, Wei Song, and ZheYong Xue et al. report an effective method to predict key genes involved in polyphyllin biosynthesis in plants. Their results provide further insight into biosynthesis pathways in Paris polyphylla, and the approach may be ...
Tongbing Su, Zheyong Xue, Baozhong Duan
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Polyphyllins Ameliorate Imiquimod-Induced Psoriatic Skin Barrier Disruption and Lesions in Mice by Inhibiting Inflammatory Infiltration With Accelerated Recovery Effects [PDF]
Frontiers in ImmunologyBackgroundPsoriasis is a chronic inflammatory skin disorder that significantly compromises patients’ quality of life. While dexamethasone (DEX) is effective as a first-line treatment, its adverse effects highlight the need for alternatives.
Jiannan Ma, Huiwen Zhang
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The biosynthesis of trillin 6′-O-glucoside: A low-abundance yet pharmacologically active polyphyllin from Paris polyphylla [PDF]
Synthetic and Systems BiotechnologyNatural products from medicinal plants serve as an invaluable resource for drug discovery and development. However, low-abundance natural products are often understudied due to the challenges of obtaining sufficient quantities for pharmacological testing
Yaran Suo +9 more
doaj +3 more sources
Optimization of Enzyme-Assisted Extraction of Polyphyllins From Paris Polyphylla var. Yunnanensis Rhizomes Using Response Surface Methodology [PDF]
Scientific ReportsParis polyphylla Smith var. yunnanensis (Franch.) Hand.-Mazz. (P. polyphylla var. yunnanensis) is a perennial herb of the genus Paris. As an important medicinal resource, P. polyphylla var.
He Xiahong, Linmei Dong
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Multi-Omics and Field Experiments Reveal the Mechanism of Pseudomonas palleroniana P6 Promoting the Growth and Polyphyllins Accumulation in Paris polyphylla [PDF]
BMC Plant BiologyBackground Paris polyphylla (P. polyphylla), a medicinal herb valued in traditional Chinese medicine, struggles with slow growth rate and long maturation periods, hindering sustainable cultivation and commercial production—especially for polyphyllins ...
Xinhong Wu, Shaodong Fu, Xueduan Liu
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Correction: Optimization of enzyme-assisted extraction of polyphyllins from paris polyphylla var. yunnanensis rhizomes using response surface methodology [PDF]
Scientific ReportsLinmei Dong +5 more
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RNA-Seq analysis reveals the important co-expressed genes associated with polyphyllin biosynthesis during the developmental stages of Paris polyphylla [PDF]
BMC Genomics, 2022 Background Plants synthesize metabolites to adapt to a continuously changing environment. Metabolite biosynthesis often occurs in response to the tissue-specific combinatorial developmental cues that are transcriptionally regulated.
Xiaoyang Gao +7 more
doaj +2 more sources
Diversity, 2022 Paris polyphylla Smith is a perennial medicinal herb with records from around 2000 years ago. Polyphyllins are the main bioactive compounds of this herb, which are found to have remarkable effects on bacteriostatic, antiphlogistic, sedative, and ...
Qixuan Su +6 more
doaj +2 more sources