Results 21 to 30 of about 182 (128)

Correlation analysis between soil factors with biomass and medicinal components of Paris polyphylla var. chinensis

Guangxi Zhiwu, 2023
Inorder to study the effect of soil factors on the growth and medicinal component of Paris polyphylla var. chinensis, the biomass and the polyphyllin contents of different samples from different origins were determined, soil composition was measured, and
Ke XIA, Zhiguo ZHAO, Qiaofen WU, Xiujuan LI, Wenjun ZHENG, Shuo QIU   +5 more
doaj   +1 more source

Proteomics Analysis of Polyphyllin D-Treated Triple-Negative Breast Cancer Cells Reveal the Anticancer Mechanisms of Polyphyllin D

Applied Biochemistry and Biotechnology, 2023
AbstractPolyphyllin D (PD), one of the important steroid saponins in traditional medicinal herb Paris polyphylla, has been demonstrated to have anticancer activity both in vitro and in vivo. However, the mechanisms through which PD exerts its anticancer effects in triple-negative breast cancer (TNBC) remain unclear.
Wei, Chuanchao, Mao, Anwei, Liu, Yongzhi, Zhang, Qing, Pan, Gaofeng, Liu, Weiyan, Liu, Jiazhe   +6 more
openaire   +2 more sources

Antitumor effect of polyphyllin D on liver metastases of neuroblastoma

Pediatric Surgery International, 2022
Abstract PurposeWe previously reported that polyphyllin D, a main component of the traditional Chinese medicinal herb Paris polyphylla, exhibited anticancer effects in vitro against human neuroblastoma cells. The aim of this investigation was to examine the presence or absence of in vivo anti-metastasis effects of polyphyllin D ...
Yasuhiro, Kondo, Shunsuke, Watanabe, Atsuki, Naoe, Toshiyuki, Takeuchi, Atsuko, Niimi, Motoshi, Suzuki, Naoya, Asai, Seiji, Okada, Tomonori, Tsuchiya, Mika, Murayama, Toshihiro, Yasui, Mikihiro, Inoue, Tatsuya, Suzuki   +12 more
openaire   +2 more sources

Polyphyllin I Inhibits Propionibacterium acnes-Induced Inflammation In Vitro [PDF]

Inflammation, 2018
Propionibacterium acnes (P. acnes) has been implicated in the progression of acne inflammation. Because current acne medications have various side effects, it is necessary to explore alternative medications possessing anti-inflammatory activity against P. acnes. We investigated the inhibitory effects of polyphyllin I (PPI) on P.
Zhu, Tingting, Wu, Wenjuan, Yang, Shuyun, Li, Donglin, Sun, Dongjie, He, Li   +5 more
openaire   +2 more sources

Polyphyllin I Effects Candida albicans via Inhibition of Virulence Factors

Evidence-Based Complementary and Alternative Medicine, 2023
Paris polyphylla is often used in Chinese medicine to treat conditions such as carbuncles, trauma, snake bites, and mosquito bites. In the present study, we investigated the effect and mechanism of the morphological transition and extracellular phospholipase activity of Candida albicans treated with polyphyllin I (PPI).
Ai-Mei Sun, Ying-Xian Wang, Guo-Xian Hu, Li Li, Rui-Rui Wang   +4 more
openaire   +2 more sources

A cycloartenol synthase from the steroidal saponin biosynthesis pathway of Paris polyphylla

, 2020
Steroidal saponins named polyphyllin are the major active components of Paris polyphylla. Cycloartenol synthase (CAS) is a key enzyme that catalyzes the formation of the sterol scaffold. In this study, we cloned a putative CAS gene from Paris polyphylla.
Si-Yuan Guo (8542251), Yan Yin (53882), Ying-Hui Shi (8542254), Wei Gao (2085), Tao Lei (404218), Jia Li (160557), Xia-Nan Zhang (3824302)   +6 more
core   +1 more source

The protective effect of polyphyllin I on myocardial ischemia/ reperfusion injury in rats

Annals of Translational Medicine, 2020
Myocardial ischemia/reperfusion (I/R) injury has become a global public health concern. An increasing amount of evidence has shown that polyphyllin I (PPI) has anti-apoptotic and antioxidant functions. This study was performed to evaluate the cardioprotective effects of PPI in a rat model of myocardial I/R injury and the underlying mechanism.We exposed
Huang, Ruizhen, Shu, Jia, Dai, Xiaoqin, Liu, Yanru, Yu, Fang, Shi, Gang   +5 more
openaire   +2 more sources

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

Phytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng, Xuelian Yuan, Yawen Xie, Zhenni Xia, Zhaohui Guo, Xuesong Liu, Rong Li, Wenliang Wang   +7 more
wiley   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, Volume 15, Issue 3, Page 206-226, September 2026.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Mass Spectrometry and NMR Spectroscopy‐Based Structural Characterization of Polysaccharide From Gastrodia elata Blume

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Structural characterization of complex carbohydrates remains challenging. This study employed methylation, acid hydrolysis, 1‐phenyl‐3‐methyl‐5‐pyrazolone (PMP) derivatization, and ultra‐high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) to determine monosaccharides, glycosidic linkages, and sequence of ...
Hui Yan, Cheng‐Xi Feng, Zhe Wang, Jun‐Qiao Wang, Shao‐Ping Nie   +4 more
wiley   +1 more source