Results 31 to 40 of about 182 (128)

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, Volume 26, Issue 7, July 2026.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Plant‐Derived Treatments for Monogenean Parasites in Farmed Fish: A Systematic Review and Meta‐Analysis

Reviews in Aquaculture, Volume 18, Issue 3, June 2026.
ABSTRACT Monogeneans are among the most problematic ectoparasites in finfish aquaculture. Plant‐derived compounds have been widely explored as therapeutic agents, yet their efficacy and safety have not been quantitatively synthesized across studies. This study provides a meta‐analysis of plant‐based treatments against monogeneans, integrating 453 in ...
Francisco Neptalí Morales‐Serna
wiley   +1 more source

Polyphyllin I inhibits the growth of ovarian cancer cells in nude mice

Oncology Letters, 2016
Polyphyllin I (PPI) is an active component in Rhizoma Paridis, which displays extensive pharmacological antitumor activities. In a previous study, we found that polyphyllin I exhibited inhibitory effects on cell growth in the human ovarian cancer HO-8910PM cell line, as well as promoting apoptosis and the inhibition of cell migration. Furthermore, gene
Gu, Linhui, Feng, Jianguo, Zheng, Zhiguo, Xu, Haiyan, Yu, Wei   +4 more
openaire   +3 more sources

Punicalagin Inhibits the Growth and Proliferation of Ovarian Epithelial Adenocarcinoma Cells Via Apoptosis and Autophagic Cell Death

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.
Punicalagin targets ovarian cancer via multiple anti‐cancer mechanisms. This graphical abstract summarizes the key findings of the study on the effects of Punicalagin (PCG), a pomegranate‐derived polyphenol, on ovarian cancer cells (OVCAR‐3 and SKOV‐3).
Zeeshan Ahmad Bhutta, Cho‐Won Kim, Hwayoung Na, Hong Kyu Lee, Kyung‐Chul Choi   +4 more
wiley   +1 more source

Biomimetic Cell Membrane‐Coated MOFs System for Targeted Cancer Therapy

Advanced Science, Volume 13, Issue 21, 13 April 2026.
Biomimetic MOF‐based drug delivery nanoplatforms synthesized using liposomes or cell membranes as camouflage for multiple cancer therapeutics. ABSTRACT The integration of metal‐organic frameworks (MOFs) with cell membrane coatings has emerged as a revolutionary strategy to enhance the therapeutic efficacy of cancer nanomedicine.
Qilu Wu, Jia Song Deon Chon, Yuxiao Feng, Kang Liang, Shiming Li, Can Yang Zhang, Jun Ge   +6 more
wiley   +1 more source

A new agent developed by biotransformation of polyphyllin VII inhibits chemoresistance in breast cancer. [PDF]

Oncotarget, 2016
Biotransformation by the endophytes of certain plants changes various compounds, and this 'green' chemistry becomes increasingly important for finding new products with pharmacological activity. In this study, polyphyllin VII (PPL7) was biotransformed by endophytes from the medicinal plant Paris polyphylla Smith, var. yunnanensis.
He DX, Li GH, Gu XT, Zhang L, Mao AQ, Wei J, Liu DQ, Shi GY, Ma X.   +8 more
europepmc   +3 more sources

Rutaceae Zanthoxylum–Derived 7‐Demethylsuberosin Alleviates the Rheumatoid Arthritis Through Inhibiting the Maturation of Dendritic Cells via Targeting MAPK14 Functional Food‐Based 7‐Demethylsuberosin

Food Frontiers, Volume 7, Issue 2, March 2026.
This study revealed that 7‐demethylsuberosin exhibits immunosuppressive effects both in vivo and in vitro. Furthermore, it inhibits the phosphorylation of MAPK14 by targeting it, thereby modulating dendritic cell (DC) maturation and function and reducing inflammation across various in vivo models.
Peng Han, Bo Wang, Luyang Han, Yanbo Zhu, Jiawei Dong, Yuekang Xu, Xiaoying Liu, Jinyao Li   +7 more
wiley   +1 more source

Identifying the Molecular Triggers of Allergic Immunity: A Systematic Approach to Allergen and Adjuvant Discovery

Allergic diseases reflect a misdirected immune response toward innocuous environmental or dietary components. While the major food allergens and their molecular identities are known, few systematic efforts have identified unique allergens or small ...
Wu, Elena
core   +3 more sources

Dual Roles of Natural Products in Regulating Ferroptosis in Acute and Chronic Liver Diseases: A Review

Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
Liver diseases, both acute and chronic, are a major global health burden with limited therapeutic options. Ferroptosis, an iron‐dependent form of regulated cell death driven by lipid peroxidation, has emerged as a key contributor to liver pathology and a potential therapeutic target.
Farshad Niazpour, Reza Meshkani, Swaran J. S. Flora   +2 more
wiley   +1 more source