Results 11 to 20 of about 182 (128)

Compartment-Specific Variation in Bacterial Microbiome and Polyphyllin Profiles in Paris polyphylla [PDF]

International Journal of Microbiology
Paris polyphylla (P. polyphylla) is a valuable traditional Chinese medicinal plant, yet the spatial distribution of its compartment-specific bacterial microbiomes and their correlative relationships with bioactive polyphyllins remain poorly characterized.
Xinhong Wu, Yan Deng, Shihui Li, Kai Zou, Zhenchun Duan, Nazidi Ibrahim, Jin Zhou, Luhua Jiang, Xueduan Liu, Shaodong Fu, Yili Liang   +10 more
doaj   +6 more sources

Metabolomics and transcriptomics profiling of three Paris species with varied polyphyllin compositions [PDF]

Scientific Data
Most of the species in Paris have important medicinal values in China. Polyphyllins are the key components in Paris, with varying levels and compositions among different species.
Ping Xu, Jia Chen, Qi Mi, Wenchun Li, You Lu, Wenxiu Luo, Mengwen Yu, Xuan Zhang, Zhenhua Tu, Honggao Xu, Guowei Zheng   +10 more
doaj   +4 more sources

Development of EST-SSR Markers Related to Polyphyllin Biosynthesis Reveals Genetic Diversity and Population Structure in Paris polyphylla

Diversity, 2022
Paris polyphylla is an important medicinal plant that can biosynthesize polyphyllins with multiple effective therapies, ranging from anti-inflammation to antitumor; however, the genetic diversity of Paris polyphylla is still unclear.
Xiaoyang Gao, Qixuan Su, Baolin Yao, Wenjing Yang, Weisi Ma, Bin Yang, Changning Liu   +6 more
doaj   +2 more sources

Polyphyllin H Reverses Paclitaxel Resistance in Breast Cancer by Binding Membrane Cholesterol to Inhibit Both ABCB1 and ABCC3 [PDF]

Pharmaceuticals
Background/Objectives: Breast cancer is the most prevalent malignancy among women, and paclitaxel (PTX) is a first-line chemotherapeutic, but chemoresistance driven by ATP-binding cassette (ABC) transporters limits its efficacy.
Zheng Ye, Chao Hong, Min Jiang, Wenkui Zou, Yaning Ren, Mingfang Li, Xinyue Xue, Xiaoting Xie, Tong Zhang, Yue Ding   +9 more
doaj   +2 more sources

Genomic insights into Aspergillus tamarii TPD11: enhancing polyphyllin production and uncovering potential therapeutic applications [PDF]

BMC Genomics
Background The excavation and utilization of endophytic fungi from medicinal plants is highly important for the development of new drugs. The endophytic fungus Aspergillus tamarii TPD11, which was isolated and obtained by the authors in the previous ...
Qing Zhang, Hai Liu, Xiaojun Zhao, Jili Yang, Weidi Tang, Ying Yang, Sheng Chang, Bo Cai, Juan Liu, Yaoshun Zhu, Bo Zhou, Tao Liu   +11 more
doaj   +2 more sources

Unveiling polyphyllin's role in neuroprotection: A pharmacological perspective

Pharmacological Research - Modern Chinese Medicine
Introduction: Polyphyllins are bioactive steroidal saponins predominantly derived from Paris polyphylla (Chinese: Chonglou, 重楼), an herb long employed in Traditional Chinese Medicine (TCM) for detoxification, inflammation control, and pain relief ...
Md Sadique Hussain, Amita Joshi Rana, Mudasir Maqbool, Nasreen Sulthana, Ayesha Sultana, Sumel Ashique, Yumna Khan, Prasanna Srinivasan Ramalingam, Sushil S. Burle, Vikas Jakhmola, Gaurav Gupta   +10 more
doaj   +2 more sources

Integrated Multi-Omics Analysis Reveals the Polyphyllins Biosynthesis in Paris polyphylla var. Yunnanensis Across Different Growth Years

Industrial Crops and Products
Growth duration significantly influences the active ingredient content of Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz, a valuable perennial Chinese medicinal herb.
Guowei Zheng
exaly   +3 more sources

Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis [PDF]

OncoTargets and Therapy, 2021
Yaser Gamallat, Muhammad Fiaz Khan, Bashir Ahmad   +2 more
exaly   +2 more sources

Haplotype-resolved autotetraploid genome of Dioscorea nipponica provides insights into recent polyploidization, metabolic rewiring, and environmental adaptation. [PDF]

Plant J
SUMMARY Whole‐genome duplication (WGD, or polyploidization) is a major evolutionary force in plants, yet the genomic, transcriptional, and metabolic consequences of autopolyploidy remain less understood than those of allopolyploidy. Dioscorea nipponica, a medicinal species producing diosgenin‐type steroidal saponins, harbors both diploid and ...
Li SS, Sun XQ, Feng Y, Hu K, Li P, Liu Y, Gu JH, Chen M, Lu RS.   +8 more
europepmc   +2 more sources

Characterization of a 4′-O-Rhamnosyltransferase and De Novo Biosynthesis of Bioactive Steroidal Triglycosides From Paris polyphylla [PDF]

Plant Communications
Qiao-Zhuo Zhang, Xiu-Lan Pu, Xue Tang
exaly   +2 more sources