Results 41 to 50 of about 182 (128)

Phorbol Myristate Acetate Inhibits Senecavirus A Replication by Activating IKBKE–Mediated IFN Pathway and NF‐κB Signal

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Senecavirus A (SVA) is an emerging picornavirus causing vesicular disease indistinguishable from foot‐and‐mouth disease virus (FMDV). So far, there are no commercial vaccines and effective therapeutic drugs against SVA infection in China. Here, a library of 112 compounds were screened, and we found that phorbol myristate acetate plays an antagonistic ...
Junfang Yan, Yanni Gao, Chengyi Guo, Yubei Dong, Ping Jiang, Juan Bai, Linzhu Ren   +6 more
wiley   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

Effects and Mechanisms of Dietary Natural Products on Ischemic Stroke: An Updated Review

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This review mainly summarizes the effects and mechanisms of dietary natural products on ischemic stroke, and highlights future research directions. Overall, this review provides a useful reference for the application of dietary natural products in the prevention and management of ischemic stroke.
Kai‐Yi Zhong, Yong Zhang, Nai‐Dong Wang, Guang‐Wen Li, Xian‐Jun Zhang, Zhi‐Jun Yang   +5 more
wiley   +1 more source

Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Native thioredoxin‐1 (TRX) stimulates proliferation and rescues stem cells and cancer cells from multiple stressors by suppressing p53 and inhibiting ferroptosis via GPX4/SLC7A11 upregulation mediated by enhanced KLF4 expression and p53 promoter binding.
Jian Wu, Xiaobei Wang, Parker Mathews, Shaima Jabbar, Min Zhang, Haim Moskowitz, Wei Duan, David P. Nichols, George William Schaaf, John D. Olson, Andrew N. Macintyre, J. Daniel Bourland, Ivan Spasojevic, Jen‐Tsan Ashley Chi, Joel Ross, Nelson Chao, J. Mark Cline, Peter B. Heifetz, Yubin Kang   +18 more
wiley   +1 more source

Integrating Nature Into Oncology: Enhancing Hematological Malignancies Therapies With Natural Medicine

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Hematological malignancies are complex clonal disorders that pose a significant threat to human health. Current treatment modalities, including radiotherapy, chemotherapy, immunotherapy, and bone marrow transplantation, have demonstrated efficacy but are often limited by side effects, drug resistance, and suboptimal cure rates.
Yaoyao Tian, Baoyi Ni, Dandan Cai, Jia Wang, Jilai Zhou, Mingqian Song, Xi Zhang, Jiakang Jiang   +7 more
wiley   +1 more source

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Paris Polyphylla Sm.: Phytochemistry, Pharmacological Activities, Molecular Mechanisms, Traditional Uses And Emerging Therapeutic Applications—A Comprehensive Review

Background: Paris polyphylla Smith.(chonglou) is an important traditional Chinese medicinal herb which has been used widely in the treatment of infectious and inflammatory diseases and cancer in China for thousands of years.
Robin Singh, Swamita Arora, Sanjar Alam, Nazli Shahin   +3 more
core   +1 more source

Programmed Cell Death in Cancer

MedComm, Volume 6, Issue 9, September 2025.
Cancer is one of the most common and lethal diseases globally, with programmed cell death (PCD) playing a pivotal role in its pathogenesis and treatment. This comprehensive review covers the origin, developmental trajectory, and mechanisms of various PCDs, as well as their molecular connections with cancers. Latest studies have increasingly highlighted
Yuang Wei, William Hankey, Dongliang Xu, Fuwen Yuan   +3 more
wiley   +1 more source

Research trends and hotspots of polyphyllin in high-incidence cancers: A bibliometric analysis

Heliyon
Polyphyllin, a natural compound derived primarily from the Paris genus, manifests its anticancer properties. Extensive research on its therapeutic potential in cancers has been reported. However, there is no systematical analysis of the general aspects of research on polyphyllin by bibliometric analysis.
Xin Jiang, Zhen Liu, Runlan Wan, Renming Cai, Jiaxin Yang, Linfeng Li, Huiling Hu, Lilan Ou, Chun Zhang, Qiuyu Liu   +9 more
openaire   +3 more sources

Polyphyllin B induces ferroptosis in triple-negative breast cancer by inactivating NRF2

Frontiers in Pharmacology
Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC) and lacks effective treatment options. Polyphyllin B (PB), a saponin extracted from Paris formosana Hayata, has shown potential in cancer therapy.
Deng, Ping, Zhu, Shouhai, Wu, Yuxuan, Fang, Zhiju, Zhang, Aini, Zhang, Dongyi, Hu, Xiaoqu, Zhou, Xiang   +7 more
openaire   +2 more sources