Results 41 to 50 of about 22,479,757 (178)

The Fruits of Paris polyphylla Inhibit Colorectal Cancer Cell Migration Induced by Fusobacterium nucleatum-Derived Extracellular Vesicles

Molecules, 2021
Colorectal cancer (CRC) is one of the most common cancers worldwide. Gut microbiota are highly associated with CRC, and Fusobacterium nucleatum was found to be enriched in CRC lesions and correlated with CRC carcinogenesis and metastases.
Liang-Tzung Lin, Yeu-Ching Shi, Chen-Yen Choong, Chen-Jei Tai   +3 more
doaj   +1 more source

Polyphyllin I suppresses the formation of vasculogenic mimicry via Twist1/VE-cadherin pathway. [PDF]

Cell Death Dis, 2018
Abstract Vasculogenic mimicry (VM) is a functional microcirculation pattern formed by aggressive tumor cells and is related to the metastasis and poor prognosis of many cancer types, including hepatocellular carcinoma (HCC). Thus far, no effective drugs have been developed to target VM.
Xiao T, Zhong W, Zhao J, Qian B, Liu H, Chen S, Chen S, Qiao K, Lei Y, Zong S, Wang H, Liang Y, Zhang H, Meng J, Zhou H, Sun T, Liu Y, Yang C.   +17 more
europepmc   +3 more sources

Polyphyllin I alleviates inflammatory injury in mice with gestational diabetes through AMPK pathway

General physiology and biophysics, 2023
Our study aimed to detect the effects of polyphyllin I (PPI) on relieving gestational diabetes mellitus (GDM), and the possible mechanism. A mouse model of GDM was constructed. The effects of PPI on GDM mice were evaluated by detecting blood glucose, insulin level, glucose tolerance test, and insulin tolerance test. The inflammation response in GDM and
Yaoyao, Cai, Fengfeng, Xie, Haiou, Wang, Qi, Zhai, Feng, Lin, Shishi, Pan   +5 more
openaire   +2 more sources

Establishment of a multicomponent quality control method and the transfer characteristics of five markers from Qidongning Formula to rat tissues by HPLC-QQQ-MS/MS

Frontiers in Pharmacology, 2023
Introduction: Traditional Chinese medicine compound preparations have become an increasingly utilized strategy for tumour treatment. Qidongning Formula (QDN) is a kind of antitumour compound preparation used in hospitals, and it can inhibit the growth of
Di Zhou, Jian-Ru Chen, Zi-Qi Yang, Ling Xu, Yu-Feng Huang   +4 more
doaj   +1 more source

Data_Sheet_1_Endophyte-inoculated rhizomes of Paris polyphylla improve polyphyllin biosynthesis and yield: a transcriptomic analysis of the underlying mechanism.CSV

, 2023
IntroductionPolyphyllin from Paris polyphylla var. yunnanensis exhibits anti-inflammatory, analgesic, antibacterial, and antiviral properties. However, the current production of polyphyllin can barely meet market demand.
Lufeng Liu (16011029), Ying Yang (24175), Qing Zhang (1802), Tao Liu (10785), Yumei Dong (819762), Congfang Xi (17303854), Sheng Chang (649642), Yu Liu (6938), Yunchao He (17303857), Bo Cai (62436)   +9 more
core   +1 more source

Data_Sheet_2_Endophyte-inoculated rhizomes of Paris polyphylla improve polyphyllin biosynthesis and yield: a transcriptomic analysis of the underlying mechanism.CSV

, 2023
IntroductionPolyphyllin from Paris polyphylla var. yunnanensis exhibits anti-inflammatory, analgesic, antibacterial, and antiviral properties. However, the current production of polyphyllin can barely meet market demand.
Lufeng Liu (16011029), Ying Yang (24175), Qing Zhang (1802), Tao Liu (10785), Yumei Dong (819762), Congfang Xi (17303854), Sheng Chang (649642), Yu Liu (6938), Yunchao He (17303857), Bo Cai (62436)   +9 more
core   +1 more source

Development of EST-SSR Markers Related to Polyphyllin Biosynthesis Reveals Genetic Diversity and Population Structure in Paris polyphylla

Diversity, 2022
Paris polyphylla is an important medicinal plant that can biosynthesize polyphyllins with multiple effective therapies, ranging from anti-inflammation to antitumor; however, the genetic diversity of Paris polyphylla is still unclear.
Xiaoyang Gao, Qixuan Su, Baolin Yao, Wenjing Yang, Weisi Ma, Bin Yang, Changning Liu   +6 more
doaj   +1 more source

Presentation_1_Endophyte-inoculated rhizomes of Paris polyphylla improve polyphyllin biosynthesis and yield: a transcriptomic analysis of the underlying mechanism.pdf

, 2023
IntroductionPolyphyllin from Paris polyphylla var. yunnanensis exhibits anti-inflammatory, analgesic, antibacterial, and antiviral properties. However, the current production of polyphyllin can barely meet market demand.
Lufeng Liu (16011029), Ying Yang (24175), Qing Zhang (1802), Tao Liu (10785), Yumei Dong (819762), Congfang Xi (17303854), Sheng Chang (649642), Yu Liu (6938), Yunchao He (17303857), Bo Cai (62436)   +9 more
core   +1 more source

Clonal Propagation and Assessment of Biomass Production and Saponin Content of Elite Accessions of Wild Paris polyphylla var. yunnanensis

Plants, 2023
Paris polyphylla var. yunnanensis is an endangered medicinal plant endemic to China with great economic importance for the pharmaceutical industry. Two significant barriers to its commercial development are the long duration of its seed germination and ...
Mulan Wang, Weiqi Li, Qi Qiang, Junchao Ma, Jiaqi Chen, Xudong Zhang, Yanxia Jia, Tie Zhang, Liang Lin   +8 more
doaj   +1 more source

Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2)

, 2021
Natural products have continued to offer tremendous opportunities for drug development, as they have long been used in traditional medicinal systems. SHP2 has served as an anticancer target.
Se Jeong Kwon, Dohee Ahn, Hyo Jin Kang, Sang J. Chung, Hyun-Mo Yang   +4 more
core   +1 more source