Results 61 to 70 of about 22,479,757 (178)

Quantitative Analysis in Combination with Fingerprint Technology and Chemometric Analysis Applied for Evaluating Six Species of Wild Paris Using UHPLC-UV-MS

Journal of Analytical Methods in Chemistry, 2016
A fast method was developed by ultra high performance liquid chromatography (UHPLC) for simultaneous determination of polyphyllin I and polyphyllin II.
Yuangui Yang, Ji Zhang, Hang Jin, Jinyu Zhang, Yuanzhong Wang   +4 more
doaj   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, Volume 15, Issue 3, Page 206-226, September 2026.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

The role of Rhizoma Paridis saponins on anti-cancer: The potential mechanism and molecular targets

Heliyon
Cancer is a disease characterized by uncontrolled cell proliferation, leading to excessive growth and invasion that can spread to other parts of the body.
Famin Ke, Ranqi Zhang, Rui Chen, Xiurong Guo, Can Song, Xiaowei Gao, Fancai Zeng, Qiuyu Liu   +7 more
doaj   +1 more source

Haplotype‐resolved autotetraploid genome of Dioscorea nipponica provides insights into recent polyploidization, metabolic rewiring, and environmental adaptation

The Plant Journal, Volume 127, Issue 6, September 2026.
SUMMARY Whole‐genome duplication (WGD, or polyploidization) is a major evolutionary force in plants, yet the genomic, transcriptional, and metabolic consequences of autopolyploidy remain less understood than those of allopolyploidy. Dioscorea nipponica, a medicinal species producing diosgenin‐type steroidal saponins, harbors both diploid and ...
Shan‐Shan Li, Xiao‐Qin Sun, Yu Feng, Ke Hu, Pan Li, Yu Liu, Jun‐Hao Gu, Min Chen, Rui‐Sen Lu   +8 more
wiley   +1 more source

Effect of provenance and water stress on biomass and polyphyllin content in the medicinal plant Paris polyphylla Smith var. yunnanensis [PDF]

, 2019
Water stress and provenance could affect the secondary metabolites synthesis and accumulation in herbs. Thus, this study explored the effect of soil water moisture and provenance on the growth of Paris polyphylla Smith var. yunnanensis (PPY).
Wu, X., Zhang, Q., Wang, Y., Zuo, .
core   +2 more sources

Mass Spectrometry and NMR Spectroscopy‐Based Structural Characterization of Polysaccharide From Gastrodia elata Blume

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Structural characterization of complex carbohydrates remains challenging. This study employed methylation, acid hydrolysis, 1‐phenyl‐3‐methyl‐5‐pyrazolone (PMP) derivatization, and ultra‐high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) to determine monosaccharides, glycosidic linkages, and sequence of ...
Hui Yan, Cheng‐Xi Feng, Zhe Wang, Jun‐Qiao Wang, Shao‐Ping Nie   +4 more
wiley   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, Volume 26, Issue 7, July 2026.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source

Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway

Pharmaceutical Biology, 2022
Context Polyphyllin II (PPII) is a steroidal saponin isolated from Rhizoma Paridis. It exhibits significant antitumor activity such as anti-proliferation and pro-apoptosis in lung cancer.Objective To explore whether PPII induce autophagy and the ...
Yuhan Jiao, Ming Xin, Juanjuan Xu, Xindong Xiang, Xuan Li, Jingjing Jiang, Xiuqin Jia   +6 more
doaj   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Polyphyllin I inhibits proliferation and metastasis of ovarian cancer cell line HO-8910PM in vitro

Journal of Traditional Chinese Medicine, 2013
To study the anticancer mechanism of polyphyllin I (PPI), a Traditional Chinese Medicine, on the ovarian cancer cell line HO-8910PM in vitro.Transwell chamber invasive assays were used to investigate the inhibitory capacity of PPI on HO-8910PM metastasis.
Gu, Linhui, Feng, Jianguo, Xu, Haiyan, Luo, Min, Su, Dan   +4 more
openaire   +2 more sources