Results 81 to 90 of about 22,479,757 (178)

Study on Synthesis and Regulation of PPVI and PPVII in Paris polyphylla with UV

Metabolites
Paris polyphylla Smith var. Chinensis (Franch.) Hara is a medicinal plant that belongs to the Liliaceae family. Its main components are parissaponins, which have excellent medicinal effects such as anti-inflammatory, anti-tumor, etc.
Dongjie Geng, Yiqun Sun, Shouzan Liu, Wen Chen, Fei Gao, Yan Bai, Shaobo Zhang   +6 more
doaj   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

Effects and Mechanisms of Dietary Natural Products on Ischemic Stroke: An Updated Review

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This review mainly summarizes the effects and mechanisms of dietary natural products on ischemic stroke, and highlights future research directions. Overall, this review provides a useful reference for the application of dietary natural products in the prevention and management of ischemic stroke.
Kai‐Yi Zhong, Yong Zhang, Nai‐Dong Wang, Guang‐Wen Li, Xian‐Jun Zhang, Zhi‐Jun Yang   +5 more
wiley   +1 more source

Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Native thioredoxin‐1 (TRX) stimulates proliferation and rescues stem cells and cancer cells from multiple stressors by suppressing p53 and inhibiting ferroptosis via GPX4/SLC7A11 upregulation mediated by enhanced KLF4 expression and p53 promoter binding.
Jian Wu, Xiaobei Wang, Parker Mathews, Shaima Jabbar, Min Zhang, Haim Moskowitz, Wei Duan, David P. Nichols, George William Schaaf, John D. Olson, Andrew N. Macintyre, J. Daniel Bourland, Ivan Spasojevic, Jen‐Tsan Ashley Chi, Joel Ross, Nelson Chao, J. Mark Cline, Peter B. Heifetz, Yubin Kang   +18 more
wiley   +1 more source

Additional file 2 of RNA-Seq analysis reveals the important co-expressed genes associated with polyphyllin biosynthesis during the developmental stages of Paris polyphylla

, 2022
Additional file 2: This PDF contains all the additional figures (Figure S1-S6) associated with the manuscript. Figure numbers and titles are listed as follows: Figure S1. BUSCO assessment results. Figure S2.
Jiawei Guo (1488853), Jing Li (10611), Shengying Li (1310157), Qixuan Su (13208025), Wenjing Yang (466552), Changning Liu (14026), Xiaoyang Gao (150076), Baolin Yao (9928079)   +7 more
core   +1 more source

Integrating Nature Into Oncology: Enhancing Hematological Malignancies Therapies With Natural Medicine

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Hematological malignancies are complex clonal disorders that pose a significant threat to human health. Current treatment modalities, including radiotherapy, chemotherapy, immunotherapy, and bone marrow transplantation, have demonstrated efficacy but are often limited by side effects, drug resistance, and suboptimal cure rates.
Yaoyao Tian, Baoyi Ni, Dandan Cai, Jia Wang, Jilai Zhou, Mingqian Song, Xi Zhang, Jiakang Jiang   +7 more
wiley   +1 more source

Additional file 1: of Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways

, 2016
Polyphyllin VII (PP7) inhibited the proliferation of human cancer cells. Cells were treated with increasing concentrations of PP7 for 24 h and cell viability was determined by MTT assay as described in Methods sections. Each IC50 value represents means ± 
Yulin Zhang (510822), Xuejing Jia (847990), Yitao Wang (313075), Jiaolin Bao (519829), Chengwei He (125487), Shenghui Chen (801841), Peng Li (69518), Jian-Bo Wan (500188), Chao Zhang (51048), Kai Wang (21246), Huanxing Su (104291), Zhinan Mei (847991)   +11 more
core   +1 more source

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives

, 2005
(Chemical Equation Presented) The synthesis of three fluorophore-appended derivatives of dioscin and polyphyllin D is reported herein. Starting from trillin, dansyl derivatives A-C were prepared in overall yields of 7-12% over 7-10 steps.
Wong, ELM, Shum, TYT, Che, CM, Hui, Y, Yang, Z   +4 more
core   +1 more source

Programmed Cell Death in Cancer

MedComm, Volume 6, Issue 9, September 2025.
Cancer is one of the most common and lethal diseases globally, with programmed cell death (PCD) playing a pivotal role in its pathogenesis and treatment. This comprehensive review covers the origin, developmental trajectory, and mechanisms of various PCDs, as well as their molecular connections with cancers. Latest studies have increasingly highlighted
Yuang Wei, William Hankey, Dongliang Xu, Fuwen Yuan   +3 more
wiley   +1 more source