Results 101 to 110 of about 22,479,757 (178)

Polyphyllin I induces ferritinophagy dependent ferroptosis through EZH2 and promotes anti-tumor immunity

Biomedicine & Pharmacotherapy
Polyphyllin I (PPI), the primary active component extracted from the commonly utilized drug Paris polyphylla, in clinical applications, exhibits exceptional anti-tumor activity. Therefore, the objective of this study is to delve into its antitumor properties by promoting ferroptosis and enhancing anti-tumor immunity.Our result demonstrate that PPI ...
Mengfei Xu, Xiaoyan Yu, Luyu Jia, Mingnan Ye, Yueyang Zhao, Rui Wang, Qing Tang, Gangxing Zhu, Jicai Chen, Qichun Zhou, Shigui Deng, Sumei Wang   +11 more
openaire   +2 more sources

Effects of polyphyllin D on the induction of apoptosis in human hepatocellular carcinoma HepG2 cells and its multidrug resistant derivative RHepG2 cells. [PDF]

, 2004
Ong Chik Ying Rose.Thesis (M.Phil.)--Chinese University of Hong Kong, 2004.Includes bibliographical references (leaves 181-195).Abstracts in English and Chinese.Acknoledgements --- p.iList of Abbreviations --- p.iiAbstract --- p.iiiAbstract in Chinese

core  

Polyphyllin I Induces Cell Cycle Arrest and Cell Apoptosis in Human Retinoblastoma Y-79 Cells through Targeting p53

, 2018
Background: Retinoblastoma is the most common intraocular malignant tumor in childhood. Although external beam radiation and enucleation are effective to control retinoblastoma, eye salvage and vision preservation are still significant challenges ...
Ke Wang, Kai Zhang, Xue Zhu, Ling Zhu, Yi Pan, Fanfan Zhou   +5 more
core   +1 more source

A cycloartenol synthase from the steroidal saponin biosynthesis pathway of Paris polyphylla

, 2020
Steroidal saponins named polyphyllin are the major active components of Paris polyphylla. Cycloartenol synthase (CAS) is a key enzyme that catalyzes the formation of the sterol scaffold. In this study, we cloned a putative CAS gene from Paris polyphylla.
Si-Yuan Guo (8542251), Yan Yin (53882), Ying-Hui Shi (8542254), Wei Gao (2085), Tao Lei (404218), Jia Li (160557), Xia-Nan Zhang (3824302)   +6 more
core   +1 more source

UHPLC-Q-TOF/MS unveils metabolic diversity in Paris L. and highlights medicinal potential of five newly identified species

Frontiers in Pharmacology
Paris species are widely distributed across China, with their rhizomes traditionally used in Chinese medicine. P. polyphylla var. chinensis (PPC) and P. polyphylla var.
Kangmeng Sun, Yingying Shao, Rong Li, Zhi Wang, Jinghan Wang, Xinyu Luan, Changqiao Wu, Liya Wang, Chunnian He, Qi Tang   +9 more
doaj   +1 more source

Optimization of enzyme-assisted extraction of polyphyllins from paris polyphylla var. yunnanensis rhizomes using response surface methodology

Scientific Reports
Paris polyphylla Smith var. yunnanensis (Franch.) Hand.-Mazz. (P. polyphylla var. yunnanensis) is a perennial herb of the genus Paris. As an important medicinal resource, P. polyphylla var.
Linmei Dong, Peng Long, Yutian Jin, Lijia Chen, Xiahong He, Rui Sun   +5 more
doaj   +1 more source

Unveiling polyphyllin's role in neuroprotection: A pharmacological perspective

Pharmacological Research - Modern Chinese Medicine
Introduction: Polyphyllins are bioactive steroidal saponins predominantly derived from Paris polyphylla (Chinese: Chonglou, 重楼), an herb long employed in Traditional Chinese Medicine (TCM) for detoxification, inflammation control, and pain relief ...
Md Sadique Hussain, Amita Joshi Rana, Mudasir Maqbool, Nasreen Sulthana, Ayesha Sultana, Sumel Ashique, Yumna Khan, Prasanna Srinivasan Ramalingam, Sushil S. Burle, Vikas Jakhmola, Gaurav Gupta   +10 more
doaj   +1 more source

Wnt/β-catenin signaling pathway inhibitors, glycyrrhizic acid, solanine, polyphyllin I, crocin, hypericin, tubeimoside-1, diosmin, and rutin in medicinal plants have better binding affinities and anticancer properties: Molecular docking and ADMET study. [PDF]

Food Sci Nutr, 2023
Egbuna C, Patrick-Iwuanyanwu KC, Onyeike EN, Uche CZ, Ogoke UP, Riaz M, Ibezim EN, Khan J, Adedokun KA, Imodoye SO, Bello IO, Awuchi CG.   +11 more
europepmc   +1 more source

Engineered Panax notoginseng polysaccharide micelles inhibit macrophage polarization and delay the progression of rheumatoid arthritis via JAK2-STAT3 signaling pathway

Journal of Nanobiotechnology
Background The imbalance of macrophage polarization plays a pivotal role in the progression of rheumatoid arthritis (RA). Reprogramming macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype is considered a promising ...
Yang Yu, Liang Kong, Rui-bo Guo, Ya-ni Zhang, Shu-tong Li, Feng-yuan Zhang, Xin Wang, Yang Liu, Xiu-Ying Li, Xue-tao Li   +9 more
doaj   +1 more source

Anticancer Effect of Polyphyllin I in Suppressing Stem Cell-Like Properties of Hepatocellular Carcinoma via the AKT/GSK-3β/β-Catenin Signaling Pathway. [PDF]

Oxid Med Cell Longev, 2022
Liao M, Du H, Wang B, Huang J, Huang D, Tong G.   +5 more
europepmc   +1 more source