Results 111 to 120 of about 22,479,757 (178)

Synthesis of Active Steroidal Glycosides and Flavonoid Glycosides

, 2003
甾体皂甙和黄酮体甙是自然界广泛存在的糖缀合物，它们是许多药用植物的活性成份，具有多种生物活性。本论文完成了一系列甾体皂甙和黄酮体甙的合成和结构确定工作，为测试其生物活性、研究构效关系和药物开发奠定基础。 i)Polyphyllin D合成方法的改进： Polyphyllin D是一个具有2，4分枝的三糖甾体皂甙，它具有良好细胞毒性。以D—葡萄糖和薯蓣甙元为起始原料，经保护基操作和糖苷化反应得到关键的二醇受体15。在TMSOTf的促进下，15与Piv保护的鼠李糖三氯亚胺酯给体21反应，以71 ...
李明
core   +1 more source

Natural products target the NRF2-ferroptosis axis in hepatocellular carcinoma: tumor sensitization versus hepatoprotection

Frontiers in Pharmacology
Hepatocellular carcinoma (HCC) remains a major cause of cancer mortality. First-line systemic therapy is now led by immune checkpoint inhibitor (ICI)-based regimens, notably atezolizumab plus bevacizumab and durvalumab plus tremelimumab, whereas ...
Zugen Cheng, Ping Rong
doaj   +1 more source

Polyphyllin I Inhibits Propionibacterium acnes-Induced IL-8 Secretion in HaCaT Cells by Downregulating the CD36/NOX1/ROS/NLRP3/IL-1β Pathway. [PDF]

Evid Based Complement Alternat Med, 2021
Yang S, Jiang Y, Yu X, Zhu L, Wang L, Mao J, Wang M, Zhou N, Yang Z, Liu Y, Zhu T.   +10 more
europepmc   +1 more source

Multi-omics and field experiments reveal the mechanism of Pseudomonas palleroniana P6 promoting the growth and polyphyllins accumulation in Paris polyphylla

BMC Plant Biology
Background Paris polyphylla (P. polyphylla), a medicinal herb valued in traditional Chinese medicine, struggles with slow growth rate and long maturation periods, hindering sustainable cultivation and commercial production—especially for polyphyllins ...
Xinhong Wu, Shihui Li, Yan Deng, Zhenchun Duan, Yiran Li, Luhua Jiang, Xueduan Liu, Shaodong Fu, Yili Liang   +8 more
doaj   +1 more source

Antitumor effects of polyphyllin D, a steroidal saponin found in paris polyphylla, on two human breast cancer cell lines MCF-7 and MDA-MB-231. [PDF]

, 2003
Lee Mei-sze.Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.Includes bibliographical references (leaves 123-133).Abstracts in English and Chinese.ACKOWLEDGEMENT --- p.iABSTRACT --- p.iiABSTRACT in Chinese (摘要） --- p.ivLIST OF FIGURES AND ...

core  

Polyphyllin I Orchestrates Autophagy to Reprogram the Tumour Immune Microenvironment and Abrogate Cisplatin Resistance in Non-Small Cell Lung Cancer. [PDF]

Clin Exp Pharmacol Physiol
Liu Z, Li Y, Li S, Wang Z, Zhao H, Ke K, Wan C, Shi X.   +7 more
europepmc   +1 more source

RETRACTED: Luo et al. Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway. <i>Int. J. Mol. Sci.</i> 2022, <i>23</i>, 9368. [PDF]

Int J Mol Sci
Luo Q, Jia L, Huang C, Qi Q, Jahangir A, Xia Y, Liu W, Shi R, Tang L, Chen Z.   +9 more
europepmc   +1 more source

Polyphyllin I, a lethal partner of Palbociclib, suppresses non-small cell lung cancer through activation of p21/CDK2/Rb pathway in vitro and in vivo.

Cell Cycle, 2021
Shen Z, Wang J, Ke K, Chen R, Zuo A, Zhang R, Wan W, Xie X, Li X, Song N, Fu H, Zhang Z, Cai E, Shen J, Zhang Q, Shi X.   +15 more
europepmc   +1 more source

Polyphyllin I enhances tumor necrosis factor-related apoptosis-inducing ligand-induced inhibition of human osteosarcoma cell growth downregulating the Wnt/β-catenin pathway. [PDF]

J Tradit Chin Med
Junli C, Fulai Z, Xingyuan S, Xiaoping MA, Peng Z, Chujie Z, Binhao S, Wenchao GU, Yongjun W, Yanping Y.   +9 more
europepmc   +1 more source

Polyphyllin I induces cell cycle arrest in prostate cancer cells via the upregulation of IL6 and P21 expression. [PDF]

Medicine (Baltimore), 2019
Zhang D, Liu S, Liu Z, Ma C, Jiang Y, Sun C, Li K, Cao G, Lin Z, Wang P, Zhang J, Xu D, Kong F, Zhao S.   +13 more
europepmc   +1 more source