Results 91 to 100 of about 22,479,757 (178)

Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing

, 2023
Inflammatory pain, sustained by a complex network of inflammatory mediators, is a severe and persistent illness affecting many of the general population.
Wang, Tingting, Yi, Mengqin, Luo, Zhenhui, Tang, Dan, Zhang, Zhenglang, Zeng, Hekun, Nie, Hong, Li, Peiyang, Verkhratsky, Alexei; id_orcid, Zaib, Muhammad Haris   +9 more
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Effects of Rhizoma Parisdis total saponins and its main compounds on gastric emptying via regulating muscarinic receptors in vitro and in vivo

, 2017
The aim of this study was to explore the inhibitory effect of Rhizoma Parisdis total Saponins (RPS) and the main monomer compounds (polyphyllin I, II, VI and H) on gastric emptying and gastrointestinal motilityin vitroandin vivo.
Liying Han, Shuli Man, Yuanxue Liu, Zhen Liu, Yu Wang, Wenyuan Gao, Genbei Wang, Changxiao Liu, Ting Xia   +8 more
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Inhibition of EZH2 via activation of SAPK

, 2016
Polyphyllin I (PPI), a bioactive phytochemical extracted from the Rhizoma of Paris polyphylla , has been reported to exhibit anti-cancer activity.
Fang Zheng, Longmei Li, Qing Tang, JingJing Wu, WanYin Wu, Swei Sunny Hann   +5 more
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Optimization of ultrasound-assisted extraction of two saponins from Paris polyphylla var. yunnanensis leaves using response surface methodology [PDF]

Paris polyphylla var. yunnanensis is one of the famous Chinese herbs, in which two saponins (polyphyllin II and polyphyllin VII) have anticancer effects. The endangerment of Paris polyphylla var.
Huaxiong Lei, Aizhong Liu, Zhengxiong Zhao, Yutian Jin, Kunyao Guo, Ping Li, Qing Qiao, Xianming Guo, Rui Sun   +8 more
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Simultaneous determination of Polyphyllin I and Polyphyllin II from Rhyzoma Paridis dog plasma by a rapid HPLC and its application to pharmacokinetic study after oral administration

Journal of Medicinal Plants Research, 2012
For the first time, a rapid and specific reversed phase-high performance liquid chromatography-ultraviolet (RP-HPLC-UV) method was developed for the analysis of polyphyllin I and polyphyllin II in beagle dog plasma. The method was applied to study the pharmacokinetics of Rhizoma paridis capsule containing polyphyllin I and polyphyllin II.
openaire   +1 more source

Paris polyphylla subsp. roots

, 2018
<i>5.9. HPLC method for detecting steroid saponins in P. polyphylla roots</i> <p>For HPLC, an aliquot of the same fresh plant root material that was used for expression analysis was freeze-dried at −50 ̊C for 8 h, and then ...
Gao, Linhui, Yin, Yan, Gao, Wei, Zhang, Xianan   +3 more
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Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial–mesenchymal transition

Phytomedicine
The active ingredients of the Chinese medical herb Paris polyphylla, P. polyphylla ethanol extract (PPE) and polyphyllin I (PPI), potentially inhibit epithelial-mesenchymal transition (EMT) in tumors. However, the roles of these ingredients in inhibiting EMT in adenomyosis (AM) remain to be explored.The primary goal of the study was to uncover the ...
Ya-xin Shi, Li Xu, Xin Wang, Ke-ke Zhang, Cheng-yuan Zhang, Hong-yun Liu, Ping-ping Ding, Wei Shi, Zhi-yong Liu   +8 more
openaire   +2 more sources

Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition

Frontiers in Pharmacology, 2019
Epithelial-to-mesenchymal transition (EMT) is a self-regulated physiological process required for tissue repair that, in non-controled conditions may lead to fibrosis, angiogenesis, loss of normal organ function or cancer.
Lorena Avila-Carrasco, Pedro Majano, José Antonio Sánchez-Toméro, José Antonio Sánchez-Toméro, Rafael Selgas, Rafael Selgas, Manuel López-Cabrera, Manuel López-Cabrera, Abelardo Aguilera, Abelardo Aguilera, Guadalupe González Mateo, Guadalupe González Mateo, Guadalupe González Mateo   +12 more
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Polyphyllin I (PPI) increased the sensitivity of hepatocellular carcinoma HepG2 cells to chemotherapy.

International journal of clinical and experimental medicine, 2016
In this study the antitumor effects of polyphyllin I (PPI) were investigated in hepatocellular carcinoma HepG2 cells. Our data showed that PPI treatment exerted dose-dependent cytotoxicity on HepG2 cells as previously reported. Furthermore, PPI could sensitize HepG2 cells to cisplastin treatment in concentration-dependent manner.
Wenhao, Han, Guoxin, Hou, Lei, Liu
openaire   +1 more source

Crosstalk of NF-κB/P65 and LncRNA HOTAIR-Mediated Repression of MUC1 Expression Contribute to Synergistic Inhibition of Castration-Resistant Prostate Cancer by Polyphyllin 1–Enzalutamide Combination Treatment

Cellular Physiology and Biochemistry, 2018
Background/Aims: Polyphyllin I (PPI), one of the steroidal saponins in Paris polyphylla, reportedly exhibits antitumor effects. However, the detailed mechanism underlying PPI, particularly in enhancing the effect of the androgen receptor inhibitor ...
SongTao Xiang, PeiLiang Zou, JingJing Wu, Fang Zheng, Qing Tang, Jianfu Zhou, Swei Sunny Hann   +6 more
doaj   +1 more source