Results 31 to 40 of about 22,479,757 (178)

Polyphyllin I Inhibits Propionibacterium acnes-Induced Inflammation In Vitro. [PDF]

Inflammation, 2019
Propionibacterium acnes (P. acnes) has been implicated in the progression of acne inflammation. Because current acne medications have various side effects, it is necessary to explore alternative medications possessing anti-inflammatory activity against P. acnes. We investigated the inhibitory effects of polyphyllin I (PPI) on P.
Zhu T, Wu W, Yang S, Li D, Sun D, He L.
europepmc   +4 more sources

Polyphyllin I attenuates the invasion and metastasis via downregulating GRP78 in drug-resistant hepatocellular carcinoma cells. [PDF]

Aging (Albany NY), 2023
Drug resistance to chemotherapy agents presents a major obstacle to the effective treatment of hepatocellular carcinoma (HCC), a common type of liver cancer. Increasing evidence indicates a link between drug resistance and the recurrence of HCC. Polyphyllin I (PPI), a promising pharmaceutical candidate, has shown potential therapeutic advantages in the
Du H, Wu H, Kang Q, Liao M, Qin M, Chen N, Huang H, Huang D, Wang P, Tong G.   +9 more
europepmc   +3 more sources

Corrigendum to “The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway” [J. Pharm. Anal. 13 (2023) 39−54] [PDF]

Journal of Pharmaceutical Analysis
Zhiqi Li, Qiqi Fan, Meilin Chen, Ying Dong, Farong Li, Mingshuang Wang, Yulin Gu, Simin Guo, Xianwen Ye, Jiarui Wu, Shengyun Dai, Ruichao Lin, Chongjun Zhao   +12 more
doaj   +2 more sources

Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation. [PDF]

Transl Cancer Res, 2020
Polyphyllin I, a bioactive phytochemical extracted from Rhizoma Paridis, has been reported to exhibit anticancer activity. However, little is known about the potential of Polyphyllin I in induction of gastric cancer (GC) cell apoptosis and its underlying mechanisms.Dual-luciferase reporter assay was performed to test the bioactivity of Polyphyllin I on
Han J, Kan J, Wang X, Yuan Q, Song X, Huang M, Wu H.   +6 more
europepmc   +4 more sources

Endophyte-inoculated rhizomes of Paris polyphylla improve polyphyllin biosynthesis and yield: a transcriptomic analysis of the underlying mechanism

Frontiers in Microbiology, 2023
IntroductionPolyphyllin from Paris polyphylla var. yunnanensis exhibits anti-inflammatory, analgesic, antibacterial, and antiviral properties. However, the current production of polyphyllin can barely meet market demand.
Qing Zhang, Sheng Chang, Ying Yang, Congfang Xi, Yumei Dong, Lufeng Liu, Yunchao He, Yu Liu, Bo Cai, Tao Liu   +9 more
doaj   +1 more source

Therapeutic effects on cancer of the active ingredients in rhizoma paridis

Frontiers in Pharmacology, 2023
Cancer is a major threat to human health, with high mortality and a low cure rate, continuously challenging public health worldwide. Extensive clinical application of traditional Chinese medicine (TCM) for patients with poor outcomes of radiotherapy and ...
Jie Li, Jinhao Jia, Weiwei Zhu, Jianfei Chen, Qiusheng Zheng, Defang Li   +5 more
doaj   +1 more source

Correlation analysis between soil factors with biomass and medicinal components of Paris polyphylla var. chinensis

Guangxi Zhiwu, 2023
Inorder to study the effect of soil factors on the growth and medicinal component of Paris polyphylla var. chinensis, the biomass and the polyphyllin contents of different samples from different origins were determined, soil composition was measured, and
Ke XIA, Zhiguo ZHAO, Qiaofen WU, Xiujuan LI, Wenjun ZHENG, Shuo QIU   +5 more
doaj   +1 more source

Polyphyllin I inhibits the growth of ovarian cancer cells in nude mice. [PDF]

Oncol Lett, 2016
Polyphyllin I (PPI) is an active component in Rhizoma Paridis, which displays extensive pharmacological antitumor activities. In a previous study, we found that polyphyllin I exhibited inhibitory effects on cell growth in the human ovarian cancer HO-8910PM cell line, as well as promoting apoptosis and the inhibition of cell migration. Furthermore, gene
Gu L, Feng J, Zheng Z, Xu H, Yu W.
europepmc   +4 more sources

RETRACTED: Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway.

Int J Mol Sci, 2022
Colon cancer is a common malignant tumor of the digestive tract, and it is considered among the biggest killers. Scientific and reasonable treatments can effectively improve the survival rate of patients if performed in the early stages.
Luo Q, Jia L, Huang C, Qi Q, Jahangir A, Xia Y, Liu W, Shi R, Tang L, Chen Z.   +9 more
europepmc   +2 more sources

Polyphyllin I Promoted Melanoma Cells Autophagy and Apoptosis via PI3K/Akt/mTOR Signaling Pathway. [PDF]

Biomed Res Int, 2020
To investigate whether Polyphyllin I (PPI) might induce the autophagy and apoptosis of melanoma cells by regulating PI3K/Akt/mTOR signal pathway. Melanoma A375 cells were incubated with different concentrations of Polyphyllin I (0, 1.5, 3.0, and 6.0 mg/L) and PI3K/Akt/mTOR signaling pathway activator IGF‐1(20 mg/L).
Long J, Pi X.
europepmc   +4 more sources