Results 1 to 10 of about 240,390 (129)

Dissection of Transcriptome and Metabolome Insights Into the Polyphyllin Biosynthesis in Paris [PDF]

BMC Plant Biology
Background Polyphyllins are significant medicinal compounds found in Paris species, with different polyphyllins fulfilling distinct medicinal roles. Although some genes involved in polyphyllin synthesis have been identified, further exploration of the ...
Guowei Zheng, Yingsi Gao, Xiheng Wan
exaly   +6 more sources

The Biosynthesis of Trillin 6′-O-Glucoside: A Low-Abundance yet Pharmacologically Active Polyphyllin From Paris polyphylla [PDF]

Synthetic and Systems Biotechnology
Natural products from medicinal plants serve as an invaluable resource for drug discovery and development. However, low-abundance natural products are often understudied due to the challenges of obtaining sufficient quantities for pharmacological testing
Chengchao Xu, Jingjing Liao, Jiale Xing
exaly   +7 more sources

Endophyte-Inoculated Rhizomes of Paris polyphylla Improve Polyphyllin Biosynthesis and Yield: A Transcriptomic Analysis of the Underlying Mechanism [PDF]

Frontiers in Microbiology, 2023
IntroductionPolyphyllin from Paris polyphylla var. yunnanensis exhibits anti-inflammatory, analgesic, antibacterial, and antiviral properties. However, the current production of polyphyllin can barely meet market demand.
Sheng Chang
exaly   +6 more sources

RNA-Seq Analysis Reveals the Important Co-Expressed Genes Associated With Polyphyllin Biosynthesis During the Developmental Stages of Paris polyphylla [PDF]

BMC Genomics, 2022
Background Plants synthesize metabolites to adapt to a continuously changing environment. Metabolite biosynthesis often occurs in response to the tissue-specific combinatorial developmental cues that are transcriptionally regulated.
Shengying Li, Changning Liu, Jiawei Guo
exaly   +5 more sources

The Interaction Between Polyphyllin I and SQLE Protein Induces Hepatotoxicity Through SREBP-2/HMGCR/SQLE/LSS Pathway [PDF]

Journal of Pharmaceutical Analysis, 2023
Polyphyllin I (PPI) and polyphyllin II (PII) are the main active substances in the Paris polyphylla. However, liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated. In
Xianwen Ye, Fan Qiqi
exaly   +5 more sources

PPDP: A Data Portal of Paris polyphylla for Polyphyllin Biosynthesis and Germplasm Resource Exploration

Diversity, 2022
Paris polyphylla Smith is a perennial medicinal herb with records from around 2000 years ago. Polyphyllins are the main bioactive compounds of this herb, which are found to have remarkable effects on bacteriostatic, antiphlogistic, sedative, and ...
Qixuan Su, Xuan Zhang, Jing Li, Wenjing Yang, Qiang Ren, Xiaoyang Gao, Changning Liu   +6 more
doaj   +3 more sources

Development of EST-SSR Markers Related to Polyphyllin Biosynthesis Reveals Genetic Diversity and Population Structure in Paris polyphylla

Diversity, 2022
Paris polyphylla is an important medicinal plant that can biosynthesize polyphyllins with multiple effective therapies, ranging from anti-inflammation to antitumor; however, the genetic diversity of Paris polyphylla is still unclear.
Xiaoyang Gao, Qixuan Su, Baolin Yao, Wenjing Yang, Weisi Ma, Bin Yang, Changning Liu   +6 more
doaj   +3 more sources

Identification and engineering of a UDP-rhamnosyltransferase from <i>Trillium tschonoskii</i> for heterologous biosynthesis of polyphyllin Ⅱ in yeast. [PDF]

Biodes Res
Polyphyllins, a class of isospirostan-type steroidal saponins, exhibit cytotoxicity against a wide range of cancer cells. Despite extensive research, the complete biosynthetic pathway of these compounds remains elusive. To investigate these pathways, various tissues from Trillium tschonoskii were collected for sequencing, yielding 173,382 high-quality ...
Yang Y, Wang H, Wu Z, Wang X, Tong Y, Huang W, Liu X, Zhao H, Guo J, Hu Y, Zhang X.   +10 more
europepmc   +4 more sources

Genomic insights into Aspergillus tamarii TPD11: enhancing polyphyllin production and uncovering potential therapeutic applications [PDF]

BMC Genomics
Background The excavation and utilization of endophytic fungi from medicinal plants is highly important for the development of new drugs. The endophytic fungus Aspergillus tamarii TPD11, which was isolated and obtained by the authors in the previous ...
Qing Zhang, Hai Liu, Xiaojun Zhao, Jili Yang, Weidi Tang, Ying Yang, Sheng Chang, Bo Cai, Juan Liu, Yaoshun Zhu, Bo Zhou, Tao Liu   +11 more
doaj   +2 more sources

Metabolomics and transcriptomics profiling of three Paris species with varied polyphyllin compositions [PDF]

Scientific Data
Most of the species in Paris have important medicinal values in China. Polyphyllins are the key components in Paris, with varying levels and compositions among different species.
Ping Xu, Jia Chen, Qi Mi, Wenchun Li, You Lu, Wenxiu Luo, Mengwen Yu, Xuan Zhang, Zhenhua Tu, Honggao Xu, Guowei Zheng   +10 more
doaj   +2 more sources