Results 41 to 50 of about 240,390 (129)

Regulation of cyclic lipopeptide biosynthesis in Pseudomonas fluorescens by the ClpP protease [PDF]

, 2009
Cyclic lipopeptides produced by Pseudomonas species exhibit potent surfactant and broad-spectrum antibiotic properties. Their biosynthesis is governed by large multimodular nonribosomal peptide synthetases, but little is known about the genetic ...
Bruijn, I., de, Raaijmakers, J.M.
core   +1 more source

Separation and Purification of Two Saponins from Paris polyphylla var. yunnanensis by a Macroporous Resin

, 2022
An effective method for separating and purifying critical saponins (polyphyllin II and polyphyllin VII) from a Paris polyphylla var. yunnanensis extract was developed in this study which was environmentally friendly and economical.
Aizhong Liu, Anmin Yu, Guangxi Wang, Li, Ping, Qin, Long, Liu, Aizhong, Wu, Junli, Sun, Rui, Long Qin, Rui Sun, Zhang, Xiaoya, Ping Li, Junli Wu, Wang, Guangxi, Xiaoya Zhang, Yu, Anmin   +15 more
core   +1 more source

Programmed Cell Death in Cancer

MedComm, Volume 6, Issue 9, September 2025.
Cancer is one of the most common and lethal diseases globally, with programmed cell death (PCD) playing a pivotal role in its pathogenesis and treatment. This comprehensive review covers the origin, developmental trajectory, and mechanisms of various PCDs, as well as their molecular connections with cancers. Latest studies have increasingly highlighted
Yuang Wei, William Hankey, Dongliang Xu, Fuwen Yuan   +3 more
wiley   +1 more source

Polyphyllin VII increases sensitivity to gefitinib by modulating the elevation of P21 in acquired gefitinib resistant non-small cell lung cancer

, 2017
Blockade of EGFR with reversible EGFR tyrosine kinase inhibitors (TKIs) is considered the frontline strategy for advanced NSCLC with EGFR mutations. However, acquired resistance to EGFR-TKI has been observed, resulting in disease progression and limited ...
Zhenghua Fei, Hao Jiang, Honggang Wang
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Gut microbiota in health and disease: advances and future prospects

MedComm, Volume 5, Issue 12, December 2024.
This review discusses how gut microbiota influences metabolic and neurological diseases, then delves into the specific immune inflammation mechanisms related to cell death, such as pyroptosis and ferroptosis. Advanced technologies like organ‐on‐chip, single‐bacterium transcriptomics, and spatial metabolomics are highlighted for their potential in ...
Yusheng Zhang, Hong Wang, Yiwei Sang, Mei Liu, Qing Wang, Hongjun Yang, Xianyu Li   +6 more
wiley   +1 more source

Blocking Ubiquitin‐Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl‐CoA Desaturase

Advanced Science, Volume 11, Issue 18, May 15, 2024.
A novel Ubiquitin‐Specific Protease 7 (USP7) inhibitor, DHPO, is identified through in silico screening for gastric cancer (GC) treatment. DHPO demonstrates robust anti‐tumor effects, inducing ferroptosis and effectively suppressing GC growth and metastasis both in vitro and in vivo.
Xiaoqing Guan, Yichao Wang, Wenkai Yu, Yong Wei, Yang Lu, Enyu Dai, Xiaowu Dong, Bing Zhao, Can Hu, Li Yuan, Xin Luan, Kai Miao, Bonan Chen, Xiang‐Dong Cheng, Weidong Zhang, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Molecular Mechanisms of Apoptosis in HepaRG Cell Line Induced by Polyphyllin VI via the Fas Death Pathway and Mitochondrial-Dependent Pathway

, 2018
Polyphyllin VI, which is an active saponin, is mainly isolated from traditional medicinal plant Paris polyphylla, which causes liver damage in rats. In the present study, we aimed to explore the potential cytotoxicity of polyphyllin VI on the growth of ...
Xingbin Yin, Wenping Wang, Longtai You, Chunjing Yang, Xin Leng, Jian Ni, Yi Liu, Na Sai, Xiaoxv Dong   +8 more
core   +1 more source

Effect of provenance and water stress on biomass and polyphyllin content in the medicinal plant Paris polyphylla Smith var. yunnanensis [PDF]

, 2019
Water stress and provenance could affect the secondary metabolites synthesis and accumulation in herbs. Thus, this study explored the effect of soil water moisture and provenance on the growth of Paris polyphylla Smith var. yunnanensis (PPY).
Wu, X., Zhang, Q., Wang, Y., Zuo, .
core   +2 more sources

Fluorophore-Appended Steroidal Saponin (Dioscin and Polyphyllin D) Derivatives

, 2016
The synthesis of three fluorophore-appended derivatives of dioscin and polyphyllin D is reported herein. Starting from trillin, dansyl derivatives A−C were prepared in overall yields of 7−12% over 7−10 steps.
Zhiqi Yang (2692909), Chi-Ming Che (1268400), Ella Lai-Ming Wong (1958881), Tina Yuen-Ting Shum (2308552), Yongzheng Hui (2692912)   +4 more
core   +1 more source

Diversity and functional analysis of LuxR-type transcriptional regulators of cyclic lipopeptide biosynthesis in Pseudomonas fluorescens [PDF]

, 2009
Cyclic lipopeptides (CLPs) are produced by many Pseudomonas species and have several biological functions, including a role in surface motility, biofilm formation, virulence, and antimicrobial activity.
Bruijn, I., de, Raaijmakers, J.M.
core   +1 more source