Results 21 to 30 of about 1,357 (186)

Response Surface Optimization for Water-Assisted Extraction of Two Saponins from Paris polyphylla var. yunnanensis Leaves

Molecules
The process of extracting polyphyllin II and polyphyllin VII by water-assisted extraction was established and optimized in this study. Response surface methodology was used to establish a prediction model to optimize the extraction conditions.
Yutian Jin, Qing Qiao, Linmei Dong, Mokun Cao, Ping Li, Aizhong Liu, Rui Sun   +6 more
doaj   +2 more sources

Disruption of Colorectal Cancer Network by Polyphyllins Reveals Pivotal Entities with Implications for Chemoimmunotherapy [PDF]

Biomedicines, 2022
The prevalence of colorectal cancer has increased world-wide with high rates of mortality and morbidity. In the absence of efficacious drugs to treat this neoplasia, there is an imminent need to discover molecules with multifaceted effects.
Ram Siripuram, Zinka Bartolek, Ketki Patil, Saj S. Gill, S. Balakrishna Pai   +4 more
doaj   +3 more sources

Research trends and hotspots of polyphyllin in high-incidence cancers: A bibliometric analysis

Heliyon
Background: Polyphyllin, a natural compound derived primarily from the Paris genus, manifests its anticancer properties. Extensive research on its therapeutic potential in cancers has been reported.
Xin Jiang, Zhen Liu, Runlan Wan, Renming Cai, Jiaxin Yang, Linfeng Li, Huiling Hu, Lilan Ou, Chun Zhang, Qiuyu Liu   +9 more
doaj   +3 more sources

Polyphyllin B inhibited STAT3/NCOA4 pathway and restored gut microbiota to ameliorate lung tissue injury in cigarette smoke-induced mice

BMC Biotechnology
Objective Smoking was a major risk factor for chronic obstructive pulmonary disease (COPD). This study plan to explore the mechanism of Polyphyllin B in lung injury induced by cigarette smoke (CSE) in COPD.
Qing Wang, Zhiyi He, Jinqi Zhu, Mengyun Hu, Liu Yang, Hongzhong Yang   +5 more
doaj   +2 more sources

Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis [PDF]

Frontiers in Pharmacology, 2023
Background: Ferroptosis is a new form of regulated cell death characterized by the accumulation of iron-dependent lipid peroxides and membrane damages. Recent studies have identified an important role for cancer cell ferroptosis in antitumor therapy.
Fang Zheng, Fang Zheng, Yeshu Wang, Qunfang Zhang, Qunfang Zhang, Qiuyuan Chen, Chun-Ling Liang, Huazhen Liu, Feifei Qiu, Yuchao Chen, Haiding Huang, Haiding Huang, Weihui Lu, Weihui Lu, Zhenhua Dai, Zhenhua Dai   +15 more
doaj   +2 more sources

Effective prediction of biosynthetic pathway genes involved in bioactive polyphyllins in Paris polyphylla [PDF]

Communications Biology, 2022
Xin Hua, Wei Song, and ZheYong Xue et al. report an effective method to predict key genes involved in polyphyllin biosynthesis in plants. Their results provide further insight into biosynthesis pathways in Paris polyphylla, and the approach may be ...
Xin Hua, Wei Song, Kangzong Wang, Xue Yin, Changqi Hao, Baozhong Duan, Zhichao Xu, Tongbing Su, Zheyong Xue   +8 more
doaj   +4 more sources

Polyphyllin VI Induces Apoptosis and Autophagy in Human Osteosarcoma Cells by Modulation of ROS/JNK Activation

Drug Design, Development and Therapy, 2019
Yong-Liang Yuan,1,* Neng Jiang,2,* Ze-Yun Li,1 Zhi-Zhen Song,1 Zhi-Heng Yang,1 Wen-Hua Xue,1 Xiao-Jian Zhang,1 Yue Du11Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China ...
Neng Jiang, Wen-Hua Xue, Xiao-Jian Zhang
exaly   +2 more sources

The Mechanism of Polyphyllin in the Treatment of Gastric Cancer Was Verified Based on Network Pharmacology and Experimental Validation

Heliyon
Background: Polyphyllin is a class of saponins extracted from Paris polyphylla rhizomes and has been used in clinical application in China for more than 2000 years. However, the mechanism for treating gastric cancer (GC) is still unclear.
Ling Yuan, Yi Nan, Duojie Xu
exaly   +3 more sources

Paridis Rhizoma Saponins ameliorate CCl4-induced liver fibrosis via modulation of the Nrf2-HO-1/NQO-1 and TGF-β1/Smads signaling pathways [PDF]

Biochemistry and Biophysics Reports
Objective/background: Paridis Rhizoma is a common traditional Chinese medicine (TCM), possessing therapeutic effects including heat-clearing, detoxification, and liver calming effects.
Yan Hong, Shuang Geng, Huihao Ao, Mengya Fu, Xiaojun Yang, Gang Cao, Yanquan Han   +6 more
doaj   +2 more sources

Metabolomics and transcriptomics profiling of three Paris species with varied polyphyllin compositions

Scientific Data
Most of the species in Paris have important medicinal values in China. Polyphyllins are the key components in Paris, with varying levels and compositions among different species.
Ping Xu, Jia Chen, Qi Mi, Wenchun Li, You Lu, Wenxiu Luo, Mengwen Yu, Xuan Zhang, Zhenhua Tu, Honggao Xu, Guowei Zheng   +10 more
doaj   +3 more sources