Results 11 to 20 of about 1,357 (186)
Diversity of endophytic bacteria in Paris Polyphylla var. yunnanensis and their correlation with polyphyllin content [PDF]
BMC MicrobiologyBackground Paris polyphylla var. yunnanensis (PPY) is commonly used in traditional Chinese medicine formulas and folk families. Nearly more than 100 chemical substances with medicinal values have been reported in PPY, among which steroidal saponins are ...
Qing Shu +7 more
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Polyphyllin H Reverses Paclitaxel Resistance in Breast Cancer by Binding Membrane Cholesterol to Inhibit Both ABCB1 and ABCC3 [PDF]
PharmaceuticalsBackground/Objectives: Breast cancer is the most prevalent malignancy among women, and paclitaxel (PTX) is a first-line chemotherapeutic, but chemoresistance driven by ATP-binding cassette (ABC) transporters limits its efficacy.
Zheng Ye +9 more
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Molecules, 2022 An effective method for separating and purifying critical saponins (polyphyllin II and polyphyllin VII) from a Paris polyphylla var. yunnanensis extract was developed in this study which was environmentally friendly and economical.
Xiaoya Zhang +7 more
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Molecules, 2021 Natural products have continued to offer tremendous opportunities for drug development, as they have long been used in traditional medicinal systems. SHP2 has served as an anticancer target.
Se Jeong Kwon +4 more
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Bioinorganic Chemistry and Applications, 2021 Nasopharyngeal carcinoma (NPC) is a malignant tumor in southern China, and nano Traditional Chinese Medicine (TCM) represents great potential to cancer therapy.
Meng-Zhe Yang +8 more
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Journal of Pharmacological Sciences, 2017 Blockade of EGFR with reversible EGFR tyrosine kinase inhibitors (TKIs) is considered the frontline strategy for advanced NSCLC with EGFR mutations. However, acquired resistance to EGFR-TKI has been observed, resulting in disease progression and limited ...
Honggang Wang, Zhenghua Fei, Hao Jiang
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Optimization of ultrasound-assisted extraction of two saponins from Paris polyphylla var. yunnanensis leaves using response surface methodology [PDF]
Frontiers in Sustainable Food SystemsParis polyphylla var. yunnanensis is one of the famous Chinese herbs, in which two saponins (polyphyllin II and polyphyllin VII) have anticancer effects. The endangerment of Paris polyphylla var.
Xianming Guo +8 more
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Diversity, 2022 Paris polyphylla Smith is a perennial medicinal herb with records from around 2000 years ago. Polyphyllins are the main bioactive compounds of this herb, which are found to have remarkable effects on bacteriostatic, antiphlogistic, sedative, and ...
Qixuan Su +6 more
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Fluorophore-Appended Steroidal Saponin (Dioscin and Polyphyllin D) Derivatives
Organic Letters, 2005 The synthesis of three fluorophore-appended derivatives of dioscin and polyphyllin D is reported herein. Starting from trillin, dansyl derivatives A-C were prepared in overall yields of 7-12% over 7-10 steps. A study of their behavior in a variety of polar solvents suggests that dansyl derivatives A-C are capable of micellar self-assembly and can ...
Che, CM +4 more
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EFFECT OF PROVENANCE AND WATER STRESS ON BIOMASS AND POLYPHYLLIN CONTENT IN THE MEDICINAL PLANT Paris polyphylla Smith var. yunnanensis [PDF]
Acta Scientiarum Polonorum: Hortorum Cultus, 2019 Water stress and provenance could affect the secondary metabolites synthesis and accumulation in herbs. Thus, this study explored the effect of soil water moisture and provenance on the growth of Paris polyphylla Smith var. yunnanensis (PPY).
Xue-mei Wu +3 more
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