Results 31 to 40 of about 1,357 (186)

Polyphyllin II Triggers Pyroptosis in Hepatocellular Carcinoma via Modulation of the ROS/NLRP3/Caspase-1/GSDMD Axis [PDF]

Antioxidants
Pyroptosis is a type of programmed cell death (PCD) with pro-inflammatory properties, which is characterized by the swelling with bubbles and the release of LDH and inflammatory cell cytokines.
Huating Huang, Boran Ni, Qi Chen, Wenqi Wang, Zishuo Guo, Nan Wang, Rui Chen, Xingbin Yin, Changhai Qu, Jian Ni, Xiaoxv Dong   +10 more
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In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways

Molecules, 2019
Background: Polyphyllin VII (PP7), a steroidal saponin from Paris polyphylla, has been found to exert strong anticancer activity. Little is known about the anti-inflammatory property of PP7.
Chao Zhang, Chaoying Li, Xuejing Jia, Kai Wang, Yanbei Tu, Rongchun Wang, Kechun Liu, Tao Lu, Chengwei He   +8 more
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Endophyte-inoculated rhizomes of Paris polyphylla improve polyphyllin biosynthesis and yield: a transcriptomic analysis of the underlying mechanism

Frontiers in Microbiology, 2023
IntroductionPolyphyllin from Paris polyphylla var. yunnanensis exhibits anti-inflammatory, analgesic, antibacterial, and antiviral properties. However, the current production of polyphyllin can barely meet market demand.
Qing Zhang, Sheng Chang, Ying Yang, Congfang Xi, Yumei Dong, Lufeng Liu, Yunchao He, Yu Liu, Bo Cai, Tao Liu   +9 more
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Therapeutic effects on cancer of the active ingredients in rhizoma paridis

Frontiers in Pharmacology, 2023
Cancer is a major threat to human health, with high mortality and a low cure rate, continuously challenging public health worldwide. Extensive clinical application of traditional Chinese medicine (TCM) for patients with poor outcomes of radiotherapy and ...
Jie Li, Jinhao Jia, Weiwei Zhu, Jianfei Chen, Qiusheng Zheng, Defang Li   +5 more
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RNA-Seq analysis reveals the important co-expressed genes associated with polyphyllin biosynthesis during the developmental stages of Paris polyphylla

BMC Genomics, 2022
Background Plants synthesize metabolites to adapt to a continuously changing environment. Metabolite biosynthesis often occurs in response to the tissue-specific combinatorial developmental cues that are transcriptionally regulated.
Xiaoyang Gao, Qixuan Su, Jing Li, Wenjing Yang, Baolin Yao, Jiawei Guo, Shengying Li, Changning Liu   +7 more
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Correlation analysis between soil factors with biomass and medicinal components of Paris polyphylla var. chinensis

Guangxi Zhiwu, 2023
Inorder to study the effect of soil factors on the growth and medicinal component of Paris polyphylla var. chinensis, the biomass and the polyphyllin contents of different samples from different origins were determined, soil composition was measured, and
Ke XIA, Zhiguo ZHAO, Qiaofen WU, Xiujuan LI, Wenjun ZHENG, Shuo QIU   +5 more
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Proteomics Analysis of Polyphyllin D-Treated Triple-Negative Breast Cancer Cells Reveal the Anticancer Mechanisms of Polyphyllin D

Applied Biochemistry and Biotechnology, 2023
AbstractPolyphyllin D (PD), one of the important steroid saponins in traditional medicinal herb Paris polyphylla, has been demonstrated to have anticancer activity both in vitro and in vivo. However, the mechanisms through which PD exerts its anticancer effects in triple-negative breast cancer (TNBC) remain unclear.
Wei, Chuanchao, Mao, Anwei, Liu, Yongzhi, Zhang, Qing, Pan, Gaofeng, Liu, Weiyan, Liu, Jiazhe   +6 more
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Polyphyllin Ⅲ-Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT

Frontiers in Pharmacology, 2021
Ferroptosis, which is characterized by the accumulation of intracellular iron and subsequent lipid peroxidation, is a newly discovered form of regulated cell death and plays an important role in tumor suppression.
Yulu Zhou, Yulu Zhou, Jingjing Yang, Jingjing Yang, Cong Chen, Cong Chen, Zhaoqing Li, Zhaoqing Li, Yongxia Chen, Yongxia Chen, Xun Zhang, Xun Zhang, Linbo Wang, Linbo Wang, Jichun Zhou, Jichun Zhou   +15 more
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Development of EST-SSR Markers Related to Polyphyllin Biosynthesis Reveals Genetic Diversity and Population Structure in Paris polyphylla

Diversity, 2022
Paris polyphylla is an important medicinal plant that can biosynthesize polyphyllins with multiple effective therapies, ranging from anti-inflammation to antitumor; however, the genetic diversity of Paris polyphylla is still unclear.
Xiaoyang Gao, Qixuan Su, Baolin Yao, Wenjing Yang, Weisi Ma, Bin Yang, Changning Liu   +6 more
doaj   +1 more source

Antitumor effect of polyphyllin D on liver metastases of neuroblastoma

Pediatric Surgery International, 2022
Abstract PurposeWe previously reported that polyphyllin D, a main component of the traditional Chinese medicinal herb Paris polyphylla, exhibited anticancer effects in vitro against human neuroblastoma cells. The aim of this investigation was to examine the presence or absence of in vivo anti-metastasis effects of polyphyllin D ...
Yasuhiro, Kondo, Shunsuke, Watanabe, Atsuki, Naoe, Toshiyuki, Takeuchi, Atsuko, Niimi, Motoshi, Suzuki, Naoya, Asai, Seiji, Okada, Tomonori, Tsuchiya, Mika, Murayama, Toshihiro, Yasui, Mikihiro, Inoue, Tatsuya, Suzuki   +12 more
openaire   +2 more sources