Results 51 to 60 of about 1,357 (186)

Analysis of drug efficacy for inflammatory skin on an organ-chip system

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
Bacterial skin infections cause a variety of common skin diseases that require drugs that are safer than antibiotics and have fewer side effects.
Qianghua Quan   +7 more
doaj   +1 more source

Establishment of a multicomponent quality control method and the transfer characteristics of five markers from Qidongning Formula to rat tissues by HPLC-QQQ-MS/MS

open access: yesFrontiers in Pharmacology, 2023
Introduction: Traditional Chinese medicine compound preparations have become an increasingly utilized strategy for tumour treatment. Qidongning Formula (QDN) is a kind of antitumour compound preparation used in hospitals, and it can inhibit the growth of
Di Zhou   +4 more
doaj   +1 more source

Additional file 2 of RNA-Seq analysis reveals the important co-expressed genes associated with polyphyllin biosynthesis during the developmental stages of Paris polyphylla

open access: yes, 2022
Additional file 2: This PDF contains all the additional figures (Figure S1-S6) associated with the manuscript. Figure numbers and titles are listed as follows: Figure S1. BUSCO assessment results. Figure S2.
Jiawei Guo (1488853)   +7 more
core   +1 more source

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng   +7 more
wiley   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

open access: yesPrecision Medical Sciences, Volume 15, Issue 3, Page 206-226, September 2026.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Fluorophore-Appended Steroidal Saponin (Dioscin and Polyphyllin D) Derivatives

open access: yes, 2016
The synthesis of three fluorophore-appended derivatives of dioscin and polyphyllin D is reported herein. Starting from trillin, dansyl derivatives A−C were prepared in overall yields of 7−12% over 7−10 steps.
Zhiqi Yang (2692909)   +4 more
core   +1 more source

Haplotype‐resolved autotetraploid genome of Dioscorea nipponica provides insights into recent polyploidization, metabolic rewiring, and environmental adaptation

open access: yesThe Plant Journal, Volume 127, Issue 6, September 2026.
SUMMARY Whole‐genome duplication (WGD, or polyploidization) is a major evolutionary force in plants, yet the genomic, transcriptional, and metabolic consequences of autopolyploidy remain less understood than those of allopolyploidy. Dioscorea nipponica, a medicinal species producing diosgenin‐type steroidal saponins, harbors both diploid and ...
Shan‐Shan Li   +8 more
wiley   +1 more source

Mass Spectrometry and NMR Spectroscopy‐Based Structural Characterization of Polysaccharide From Gastrodia elata Blume

open access: yesFood Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Structural characterization of complex carbohydrates remains challenging. This study employed methylation, acid hydrolysis, 1‐phenyl‐3‐methyl‐5‐pyrazolone (PMP) derivatization, and ultra‐high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) to determine monosaccharides, glycosidic linkages, and sequence of ...
Hui Yan   +4 more
wiley   +1 more source

The role of Rhizoma Paridis saponins on anti-cancer: The potential mechanism and molecular targets

open access: yesHeliyon
Cancer is a disease characterized by uncontrolled cell proliferation, leading to excessive growth and invasion that can spread to other parts of the body.
Famin Ke   +7 more
doaj   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

open access: yesThe Chemical Record, Volume 26, Issue 7, July 2026.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source

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