Results 61 to 70 of about 1,357 (186)

Polyphyllin I inhibits endometriosis in vitro by inducing apoptosis and autophagy via the inactivation of AKT/mTOR signalling pathway

, 2023
Previous research has indicated that Polyphyllin I (PPI) possesses potent anticancer properties. However, its impact on endometriosis remains unexplored.
Qiwen Hu (235978), Jinhua Wang (1506), Yong Luo (138733), Xiumei Zhang (352357), Liping Li (120326), Jin Chen (130241)   +5 more
core   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Polyphyllin I inhibits the growth of ovarian cancer cells in nude mice

Oncology Letters, 2016
Polyphyllin I (PPI) is an active component in Rhizoma Paridis, which displays extensive pharmacological antitumor activities. In a previous study, we found that polyphyllin I exhibited inhibitory effects on cell growth in the human ovarian cancer HO-8910PM cell line, as well as promoting apoptosis and the inhibition of cell migration. Furthermore, gene
Gu, Linhui, Feng, Jianguo, Zheng, Zhiguo, Xu, Haiyan, Yu, Wei   +4 more
openaire   +3 more sources

Plant‐Derived Treatments for Monogenean Parasites in Farmed Fish: A Systematic Review and Meta‐Analysis

Reviews in Aquaculture, Volume 18, Issue 3, June 2026.
ABSTRACT Monogeneans are among the most problematic ectoparasites in finfish aquaculture. Plant‐derived compounds have been widely explored as therapeutic agents, yet their efficacy and safety have not been quantitatively synthesized across studies. This study provides a meta‐analysis of plant‐based treatments against monogeneans, integrating 453 in ...
Francisco Neptalí Morales‐Serna
wiley   +1 more source

Punicalagin Inhibits the Growth and Proliferation of Ovarian Epithelial Adenocarcinoma Cells Via Apoptosis and Autophagic Cell Death

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.
Punicalagin targets ovarian cancer via multiple anti‐cancer mechanisms. This graphical abstract summarizes the key findings of the study on the effects of Punicalagin (PCG), a pomegranate‐derived polyphenol, on ovarian cancer cells (OVCAR‐3 and SKOV‐3).
Zeeshan Ahmad Bhutta, Cho‐Won Kim, Hwayoung Na, Hong Kyu Lee, Kyung‐Chul Choi   +4 more
wiley   +1 more source

Discrimination of wild Paris based on near infrared spectroscopy and high performance liquid chromatography combined with multivariate analysis.

PLoS ONE, 2014
Different geographical origins and species of Paris obtained from southwestern China were discriminated by near infrared (NIR) spectroscopy and high performance liquid chromatography (HPLC) combined with multivariate analysis.
Yanli Zhao, Ji Zhang, Tianjun Yuan, Tao Shen, Wei Li, Shihua Yang, Ying Hou, Yuanzhong Wang, Hang Jin   +8 more
doaj   +1 more source

Additional file 1: of Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways

, 2016
Polyphyllin VII (PP7) inhibited the proliferation of human cancer cells. Cells were treated with increasing concentrations of PP7 for 24 h and cell viability was determined by MTT assay as described in Methods sections. Each IC50 value represents means ± 
Yulin Zhang (510822), Xuejing Jia (847990), Yitao Wang (313075), Jiaolin Bao (519829), Chengwei He (125487), Shenghui Chen (801841), Peng Li (69518), Jian-Bo Wan (500188), Chao Zhang (51048), Kai Wang (21246), Huanxing Su (104291), Zhinan Mei (847991)   +11 more
core   +1 more source

Biomimetic Cell Membrane‐Coated MOFs System for Targeted Cancer Therapy

Advanced Science, Volume 13, Issue 21, 13 April 2026.
Biomimetic MOF‐based drug delivery nanoplatforms synthesized using liposomes or cell membranes as camouflage for multiple cancer therapeutics. ABSTRACT The integration of metal‐organic frameworks (MOFs) with cell membrane coatings has emerged as a revolutionary strategy to enhance the therapeutic efficacy of cancer nanomedicine.
Qilu Wu, Jia Song Deon Chon, Yuxiao Feng, Kang Liang, Shiming Li, Can Yang Zhang, Jun Ge   +6 more
wiley   +1 more source

Rutaceae Zanthoxylum–Derived 7‐Demethylsuberosin Alleviates the Rheumatoid Arthritis Through Inhibiting the Maturation of Dendritic Cells via Targeting MAPK14 Functional Food‐Based 7‐Demethylsuberosin

Food Frontiers, Volume 7, Issue 2, March 2026.
This study revealed that 7‐demethylsuberosin exhibits immunosuppressive effects both in vivo and in vitro. Furthermore, it inhibits the phosphorylation of MAPK14 by targeting it, thereby modulating dendritic cell (DC) maturation and function and reducing inflammation across various in vivo models.
Peng Han, Bo Wang, Luyang Han, Yanbo Zhu, Jiawei Dong, Yuekang Xu, Xiaoying Liu, Jinyao Li   +7 more
wiley   +1 more source

Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing

, 2023
Inflammatory pain, sustained by a complex network of inflammatory mediators, is a severe and persistent illness affecting many of the general population.
Wang, Tingting, Yi, Mengqin, Luo, Zhenhui, Tang, Dan, Zhang, Zhenglang, Zeng, Hekun, Nie, Hong, Li, Peiyang, Verkhratsky, Alexei; id_orcid, Zaib, Muhammad Haris   +9 more
core   +1 more source