Results 71 to 80 of about 9,911 (183)

Targeting YAP1‐Mediated Tubular Cell Senescence to Attenuate Maladaptive Repair and Fibrotic Transition After Acute Kidney Injury

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
YAP1 mediates tubular cell senescence and drives maladaptive repair following AKI, promoting the AKI to CKD transition. Single‐cell RNA‐seq reveals sustained YAP1 overexpression, fibroblast activation, and pro‐fibrotic tubular cell shift. Senolytic agents or verteporfin (YAP1/TEAD1 inhibitor) suppress YAP1 activity, reduce renal senescence, alleviate ...
Zhibo Zhao, Huiping An, Yonghou Sang, Si Chen, Jinxiu Zhou, Tingting Zhang, Junhu Li, Xiaoshuang Zhou   +7 more
wiley   +1 more source

3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species

Advanced Science, Volume 13, Issue 41, 22 July 2026.
ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu, Chenhui Han, Cheng Xue, Manyi Sun, Bobo Song, Yongsong Xue, Guangyan Yang, Shaozhuo Xu, Wei Wei, Jiaming Li, Runze Wang, Jun Wu   +11 more
wiley   +1 more source

Cytogenetic Analysis of Altitude‐Associated Chromosome Variations in Campeiostachys nutans From Western Sichuan Plateau Using Multicolor GISH and ND‐FISH Approaches

Ecology and Evolution, Volume 16, Issue 7, July 2026.
The genomic and chromosomal organization of C. nutans was investigated using GISH and ND‐FISH with four oligonucleotide probes. The results showed that repetitive sequence distribution exhibited genome‐specific patterns: the H genome demonstrated high structural stability with low polymorphism, while the St genome showed moderate variation, and the Y ...
Cairong Yang, Jiezhi Yang, Yi Ou, Yueju Zhou, Zhimeng Wang, Weiliang Qi, Dingfang Luo, Yutong Qiao   +7 more
wiley   +1 more source

Gene Expression Changes During the Allo-/Deallopolyploidization Process of Brassica napus

Frontiers in Genetics, 2019
Gene expression changes due to allopolyploidization have been extensively studied in plants over the past few decades. Nearly all these studies focused on comparing the changes before and after genome merger.
Qi Pan, Bin Zhu, Dawei Zhang, Chaobo Tong, Chaobo Tong, Xianhong Ge, Shengyi Liu, Shengyi Liu, Zaiyun Li   +8 more
doaj   +1 more source

Complete Chloroplast Genome of Cardamine microzyga and Phylogenetic Analysis

Ecology and Evolution, Volume 16, Issue 7, July 2026.
This study reports the first complete chloroplast genome of Cardamine microzyga, a perennial herb from mountainous southwestern China. The genome is 154,661 bp in length with a typical quadripartite structure and contains 129 genes. Comparative genomic analyses identified several hypervariable regions (e.g., trnS‐GCU, rrn4.5S, ycf1) as promising DNA ...
Yongming Fan, Yan Wu, Heng Zeng, Can Zhao, Chu Li, Le Chen, Jian Hu, Lingjun Li   +7 more
wiley   +1 more source

Genome‐wide analysis of DNA methyltransferases in a model extremophyte, Schrenkiella parvula: Transcriptional dynamics during development and under salt stress

Annals of Applied Biology, Volume 189, Issue 1, July 2026.
Classification of DMTs into 4 subfamilies: two METs, three CMTs, three DRMs, and one DNMT2. The cis‐elements are associated with stress‐response, hormonal regulation, light‐response, and development. RNA‐seq analysis revealed differential expression of DMTs under NaCl stress.
Seher Yolcu, Amin Mirshamsi Kakhki, Ahmad Jalilian, Emre Sevindik, Ismail Turkan   +4 more
wiley   +1 more source

Characterization and Stress Response of the JmjC Domain-Containing Histone Demethylase Gene Family in the Allotetraploid Cotton Species Gossypium hirsutum

Plants, 2020
Histone modification is an important epigenetic modification that controls gene transcriptional regulation in eukaryotes. Histone methylation is accomplished by histone methyltransferase and can occur on two amino acid residues, arginine and lysine ...
Jie Zhang, Junping Feng, Wei Liu, Zhongying Ren, Junjie Zhao, Xiaoyu Pei, Yangai Liu, Daigang Yang, Xiongfeng Ma   +8 more
doaj   +1 more source

MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia

British Journal of Haematology, Volume 209, Issue 1, Page 16-27, July 2026.
Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu, Johan Rebetz, Lamya Garabet, Waleed Ghanima, Peipei Xu, Hans Wadenvik, Drew Provan, Rick Kapur, John W. Semple   +8 more
wiley   +1 more source

Polyploidy induction in Phlox paniculata L. under in vitro conditions

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2010
The objective of this work was to find an effective method of polyploidy induction using chemomutagens, colchicine and oryzalin, in diploid cultivar of Phlox paniculata ‘Fujiyama’ (syn. Mt. Fuji, Fuji).
Pavel Matiska, Hana Vejsadová
doaj   +1 more source

Diagnostic yield of OCT3/4 reflex testing in testicular biopsy

Histopathology, Volume 89, Issue 1, Page 136-143, July 2026.
GCNIS detection frequency was 48/3353 (1.4%) testicular biopsies from 42/1870 (2.2%) men who underwent testicular biopsy with or without testicular sperm extraction (TESE). OCT3/4 was particularly helpful for detecting interstitial seminoma, GCNIS coexisting with mature spermatogenesis, and focal GCNIS.
Roselyne Choiniere, Willem PA Boellaard, Geert JLH van Leenders   +2 more
wiley   +1 more source