Results 111 to 120 of about 786,143 (326)

Determination of the binding affinities of Neisseria meningitidis serogroup W capsule polymerase with two nucleotide sugar substrates

BMC Research Notes, 2018
Objective Meningococcal meningitis is a public health burden. Immunization strategies have reduced global incidence of the disease. Glycoconjugate vaccines are the most effective type of vaccine to combat most causes of meningococcal meningitis.
Abeer Sharyan, Cendy Gonzalez, Ophelia Ukaegbu, Kayla Powell, Pumtiwitt C. McCarthy   +4 more
doaj   +1 more source

Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue [PDF]

, 2011
The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria.
AD Reynolds, AM Faria, C Jokinen, C Laine, C O'Mahony, Carlos Javier Orihuela, D Bogaert, DM Musher, EJ Novak, EK Mulholland, EM Laughlin, G Oldenhove, H Christensen, HM Foy, HW Lim, I Rudan, JC Paton, Jeffrey Pido-Lopez, JL Round, JN Stoop, K Wing, KA Robinson, L Strauss, L Weiss, M Hara, M Hussain, M Lipsitch, M Livingston, M Quigley, MJ Butte, MJ van Kempen, MW Mureithi, N Iikuni, Neil A. Williams, PC Hill, PR Myles, Q Zhang, Q Zhang, Q Zhang, R Austrian, R Malley, R Malley, RM Wong, Robert S. Heyderman, S Hori, S Paust, S Rapola, S Read, S Sakaguchi, S Sakaguchi, SE Sandner, SK Obaro, SQ Crome, T Sturniolo, T Takahashi, Timothy J. Mitchell, V Davenport, William W. Kwok, X Zhang, Y Belkaid, Y Cong, YJ Lu, Z Zhang   +62 more
core   +3 more sources

Beyond FimH: Diversity and Relevance of Carbohydrate‐Binding Fimbrial Proteins in Escherichia coli

ChemBioChem, EarlyView.
This review discusses fimbrial lectins found in Escherichia coli (E. coli) other than FimH, which could be targeted to treat E. coli pathogenicity as an alternative to antibiotic treatment. Escherichia coli (E. coli) is responsible for multiple diseases in humans and animals.
Oliwier R. Dulawa, Shane M. Coyle, Fiona Walsh, Trinidad Velasco‐Torrijos   +3 more
wiley   +1 more source

Socioeconomic determinants of vaccination against pneumococcus in 763 945 patients with heart failure

ESC Heart Failure, EarlyView.
Respiratory infections heighten risks for heart failure (HF) patients, yet 2020 data from France show low vaccination rates: 12.6% for pneumococcus and 63.1% for influenza. Using logistic regression on 763,945 HF patients, older age, female sex, and social deprivation were associated with lower pneumococcus vaccination, despite frequent healthcare ...
F. Roubille, B. Wyplosz, J. Fernandes, B. Grenier, F. Raguideau, E. Blanc, G. Goussiaume   +6 more
wiley   +1 more source

A computational pipeline for the diagnosis of CVID patients [PDF]

, 2019
Common variable immunodeficiency (CVID) is one of the most frequently diagnosed primary antibody deficiencies (PADs), a group of disorders characterized by a decrease in one or more immunoglobulin (sub) classes and/or impaired antibody responses caused ...
Bogaert, Delfien, Dullaers, Melissa, Emmaneel, Annelies, Haerynck, Filomeen, Saeys, Yvan, Tavernier, Simon, Van Gassen, Sofie   +6 more
core   +2 more sources

Conjugate vaccines and polysaccharide response [PDF]

Canadian Medical Association Journal, 2006
Purified polysaccharide vaccines work by activation of B cells in a T-independent manner, producing predominantly IgM and little memory B cells.[1][1] Protein-polysaccharide conjugate vaccines (such as Prevnar/PCV7 which uses 7 prevalent polysaccharides to bind to non-toxic variant of ...
openaire   +2 more sources

Synthesis of Rare‐Bacterial Sugar Analogs: Thomosamine and Fluorinated Thomosamine

European Journal of Organic Chemistry, EarlyView.
We present the synthesis of protected thomosamine (4‐amino‐4,6‐dideoxy‐d‐galactopyranose), 3‐deoxy‐3‐fluoro‐thomosamine, and 2,3‐dideoxy‐2,3‐difluoro‐thomosamine from levoglucosan (1,6‐anhydro‐β‐d‐glucopyranose). Bacterial carbohydrates that include unusual deoxy amino sugars represent interesting targets in drug discovery.
Sam Bahadori, Mathilde Grosset‐Magagne, Denis Giguère   +2 more
wiley   +1 more source

Progress and prospect of polysaccharides as adjuvants in vaccine development

Virulence
Vaccines are an effective approach to confer immunity against infectious diseases. Modern subunit vaccines offer more precise target and safe protection compared to traditional whole-pathogen vaccines.
Xinlong Liang, Jiaying Zhou, Mengmeng Wang, Jing Wang, Houhui Song, Yigang Xu, Yuan Li   +6 more
doaj   +1 more source

Development of a Promising Bivalent Vaccine Against Klebsiella pneumoniae Based on Glycoengineered GMMA (geGMMA)

Exploration, EarlyView.
Multidrug‐resistant Klebsiella pneumoniae poses a significant threat as a nosocomial pathogen, with no current licensed vaccines available. This study used a mutant E. coli strain expressing exogenous polysaccharides (from K. pneumoniae) to establish glycoengineered generalized modules for membrane antigens (geGMMA) vaccine platform, which demonstrated
Jingqin Ye, Wenhua Huang, Shujuan Yu, Yan Guo, Peng Sun, Ziyuan Chen, Linhui Hao, Yan Zhang, Caixia Li, Yongqiang Jiang, Jun Wu, Li Zhu, Hengliang Wang, Chao Pan   +13 more
wiley   +1 more source

Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. [PDF]

, 2019
BackgroundAlzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline.
Agadjanyan, Michael G, Antonyan, Tatevik, Blurton-Jones, Mathew, Chailyan, Gor, Coburn, Morgan A, Cribbs, David H, Danhash, Emma, Davtyan, Hayk, Ghochikyan, Anahit, Hovakimyan, Armine, Kiani Shabestari, Sepideh, Petrovsky, Nikolai, Petrushina, Irina, Svystun, Olga, Zagorski, Karen   +14 more
core