Results 11 to 20 of about 29,849 (247)

Promising directions for vaccine development to prevent shigellosis

Биопрепараты: Профилактика, диагностика, лечение, 2022
Shigellosis (bacterial dysentery) is an acute infectious disease caused by Shigella spp., members of the Enterobacteriaceae family. The disease has the highest mortality rate amongst bacterial enteric infections.
M. V. Abramtseva, E. O. Nemanova, N. S. Alekhina   +2 more
doaj   +1 more source

Non-capsular based immunization approaches to prevent Streptococcus pneumoniae infection

Frontiers in Cellular and Infection Microbiology, 2022
Streptococcus pneumoniae is a Gram-positive bacterium and the leading cause of bacterial pneumonia in children and the elderly worldwide. Currently, two types of licensed vaccines are available to prevent the disease caused by this pathogen: the 23 ...
Pedro H. Silva, Pedro H. Silva, Yaneisi Vázquez, Yaneisi Vázquez, Camilo Campusano, Camilo Campusano, Angello Retamal-Díaz, Margarita K. Lay, Christian A. Muñoz, Pablo A. González, Pablo A. González, Alexis M. Kalergis, Alexis M. Kalergis, Susan M. Bueno, Susan M. Bueno   +14 more
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Polyvalent pneumococcal polysaccharide vaccines [PDF]

Journal of Infection, 1979
A 14-valent pneumococcal vaccine has recently been licensed for general use after extensive testing in human subjects. Antibody production was satisfactory in 92% of individuals and a highly significant (76-92%) reduction was found in the rates for pneumococcal pneumonias caused by the capsular types present in the vaccine. Children over 2 years of age
M R, Hilleman, A A, McLean, P P, Vella, R E, Weibel, A F, Woodhour   +4 more
openaire   +2 more sources

Carrier Proteins Facilitate the Generation of Antipolysaccharide Immunity via Multiple Mechanisms

mBio, 2022
Capsular polysaccharides (CPSs) are important antigenic targets against bacterial infections. As T-independent antigens, however, CPSs elicit short-lived immune responses in adults and are poorly immunogenic in young children.
Fan Zhang, Claudette Thompson, Nicole Ma, Ying-Jie Lu, Richard Malley   +4 more
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Longitudinal multiparameter single-cell analysis of macaques immunized with pneumococcal protein-conjugated or unconjugated polysaccharide vaccines reveals distinct antigen specific memory B cell repertoires.

PLoS ONE, 2017
BackgroundThe efficacy of protein-conjugated pneumococcal polysaccharide vaccines has been well characterized for children. The level of protection conferred by unconjugated polysaccharide vaccines remains less clear, particularly for elderly individuals
Bin Jia, Lisa K McNeil, Christopher D Dupont, Konstantinos Tsioris, Rachel M Barry, Ingrid L Scully, Adebola O Ogunniyi, Christopher Gonzalez, Michael W Pride, Todd M Gierahn, Paul A Liberator, Kathrin U Jansen, J Christopher Love   +12 more
doaj   +1 more source

Reduction of free polysaccharide contamination in the production of a 15-valent pneumococcal conjugate vaccine.

PLoS ONE, 2020
Glycoconjugate vaccines are vaccines in which a bacterial polysaccharide antigen is conjugated to a carrier protein to enhance immunogenicity by promoting T cell-dependent immune response. However, the free (unreacted) polysaccharides remaining after the
Yoon Hee Whang, Soo Kyung Kim, Hyeseon Yoon, Seuk Keun Choi, Yeong Ok Baik, Chankyu Lee, Inhwan Lee   +6 more
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PROTEINS AND OTHER CARRIERS FOR CREATION OF CONJUGATED VACCINES: PROPERTIES AND APPLICATION

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Vaccination is a key element in prophylaxis of infectious diseases. Effective vaccines based on polysaccharide capsules were developed for a number of microorganisms. Effectiveness of polysaccharides as antigens, however, is low in the main risk groups -
L. A. Lisitskaya, A. V. Kolesnikov, A. V. Kozyr, I. G. Shemyakin, A. K. Ryabko, O. N. Krasavtseva, LA. .. Dyatlov   +6 more
doaj   +1 more source

A universal UHPLC-CAD platform for the quantification of polysaccharide antigens

Scientific Reports, 2023
Several glycoconjugate-based vaccines against bacterial infections have been developed and licensed for human use. Polysaccharide (PS) analysis and characterization is therefore critical to profile the composition of polysaccharide-based vaccines. For PS
A. Corrado, M. De Martino, V. Bordoni, S. Giannini, F. Rech, S. Cianetti, F. Berti, C. Magagnoli, R. De Ricco   +8 more
doaj   +1 more source

SEROTYPE-INDEPENDENT VACCINES AGAINST PNEUMOCOCCAL INFECTION

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Creation of serotype-independent vaccines includes 4 directions - construction of protein vaccines based on recombinant pneumococcus proteins, whole-cell killed or attenuated vaccines, DNA-vaccines and use of Streptococcus pneumoniae as a carrier for ...
I. B. Semenova, N. A. Mikhailova
doaj   +1 more source

Safety, immunogenicity and dose ranging of a new Vi-CRM₁₉₇ conjugate vaccine against typhoid fever: randomized clinical testing in healthy adults. [PDF]

PLoS ONE, 2011
Typhoid fever causes more than 21 million cases of disease and 200,000 deaths yearly worldwide, with more than 90% of the disease burden being reported from Asia.
Pierre van Damme, Froukje Kafeja, Alessandra Anemona, Venere Basile, Anne Katrin Hilbert, Ilse De Coster, Simona Rondini, Francesca Micoli, Rana M Qasim Khan, Elisa Marchetti, Vito Di Cioccio, Allan Saul, Laura B Martin, Audino Podda   +13 more
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