Results 11 to 20 of about 756,756 (215)

The impact of protein-conjugate polysaccharide vaccines: an endgame for meningitis? [PDF]

Philos Trans R Soc Lond B Biol Sci, 2013
The development and implementation of conjugate polysaccharide vaccines against invasive bacterial diseases, specifically those caused by the encapsulated bacteria Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae, has been one ...
M. Maiden
semanticscholar   +2 more sources

Evaluating Bacillus Calmette-Guérin Polysaccharide Nucleic Acid as an Adjuvant for Influenza Vaccines in Mice. [PDF]

Influenza Other Respir Viruses
ABSTRACT Background To enhance influenza vaccine efficacy, it is essential to investigate new adjuvants that are both safe and effective. In a recent study utilizing a mouse model, Bacillus Calmette–Guérin polysaccharide nucleic acid (BCG‐PSN) emerged as a promising candidate vaccine adjuvant.
Yan S, Yang F, Ji J, Lin X, Wang P, Wu H, Cheng L, Liu F, Wu N, Yao H, Wu WSJ, Wu H.   +11 more
europepmc   +2 more sources

Are the pneumococcal polysaccharide vaccines effective? Meta-analysis of the prospective trials [PDF]

BMC Family Practice, 2000
The objective was to review the evidence of effectiveness of the polyvalent polysaccharide pneumococcal vaccine from prospective properly randomised controlled trials comparing pneumococcal vaccines with placebo in subjects who are immunocompetent and ...
R. Moore, P. Wiffen, Benjamin A Lipsky
semanticscholar   +2 more sources

The baboon as a nonhuman primate model for assessing the effects of maternal immunization with Haemophilus influenzae type b polysaccharide vaccines [PDF]

Infection and Immunity, 1997
M. Shearer, A. Lucas, P. Anderson, K. Carey, H. Jenson, T. Chanh, J. Stanley, R. Kennedy   +7 more
semanticscholar   +2 more sources

Polysaccharide structure dictates mechanism of adaptive immune response to glycoconjugate vaccines

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Helper T cell responses to glycoconjugate vaccines are regulated through mechanisms dependent upon the structure of the polysaccharide. We show that three of the four important conjugate vaccines tested induced antibody responses regulated ...
XiMei Sun, Giuseppe Stefanetti, F. Berti, Dennis L. Kasper   +3 more
semanticscholar   +1 more source

Randomized Clinical Trial To Evaluate the Immunogenicity of Quadrivalent Meningococcal Conjugate and Polysaccharide Vaccines in Adults in the United Kingdom

Clinical and Vaccine Immunology, 2014
Meningococcal conjugate vaccines are today successfully deployed in universal programs for children and adolescents in different geographic regions to control meningitis and septicemia.
M. Ramasamy, E. Clutterbuck, K. Haworth, J. Bowman, Omar Omar, A. Thompson, Geraldine Blanchard-Rohner, Ly-Mee Yu, M. Snape, A. Pollard   +9 more
semanticscholar   +1 more source

A Review of Pneumococcal Vaccines: Current Polysaccharide Vaccine Recommendations and Future Protein Antigens.

The Journal of Pediatric Pharmacology and Therapeutics, 2016
This review describes development of currently available pneumococcal vaccines, provides summary tables of current pneumococcal vaccine recommendations in children and adults, and describes new potential vaccine antigens in the pipeline.
Calvin C. Daniels, P. D. Rogers, Chasity M Shelton   +2 more
semanticscholar   +1 more source

Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells

Journal of Infectious Diseases, 2012
Background. A 23-valent unconjugated pneumococcal polysaccharide vaccine (23vP), routinely administered at the age of 65, has limited effectiveness, and revaccination induces attenuated antibody responses.
E. Clutterbuck, R. Lazarus, Ly-Mee Yu, J. Bowman, E. Bateman, L. Diggle, B. Angus, T. Peto, P. Beverley, D. Mant, A. Pollard   +10 more
semanticscholar   +1 more source

Protein Conjugate Polysaccharide Vaccines: Challenges in Development and Global Implementation

Indian Journal of Community Medicine, 2012
Pneumonia and meningitis caused by Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis are among the leading causes of under five mortality and morbidity.
M. Nair
semanticscholar   +1 more source

Comparison of pneumococcal conjugate polysaccharide and free polysaccharide vaccines in elderly adults: conjugate vaccine elicits improved antibacterial immune responses and immunological memory.

Clinical Infectious Diseases, 2008
BACKGROUND High functional antibody responses, establishment of immunologic memory, and unambiguous efficacy in infants suggest that an initial dose of conjugated pneumococcal polysaccharide (PnC) vaccine may be of value in a comprehensive adult ...
A. Roux, B. Schmoele-Thoma, G. Siber, J. Hackell, A. Kuhnke, N. Ahlers, S. Baker, A. Razmpour, E. Emini, P. Fernsten, W. Gruber, S. Lockhart, O. Burkhardt, T. Welte, H. Lode   +14 more
semanticscholar   +2 more sources