Results 31 to 40 of about 291,495 (261)

Longitudinal multiparameter single-cell analysis of macaques immunized with pneumococcal protein-conjugated or unconjugated polysaccharide vaccines reveals distinct antigen specific memory B cell repertoires.

PLoS ONE, 2017
BackgroundThe efficacy of protein-conjugated pneumococcal polysaccharide vaccines has been well characterized for children. The level of protection conferred by unconjugated polysaccharide vaccines remains less clear, particularly for elderly individuals
Bin Jia, Lisa K McNeil, Christopher D Dupont, Konstantinos Tsioris, Rachel M Barry, Ingrid L Scully, Adebola O Ogunniyi, Christopher Gonzalez, Michael W Pride, Todd M Gierahn, Paul A Liberator, Kathrin U Jansen, J Christopher Love   +12 more
doaj   +1 more source

PROTEINS AND OTHER CARRIERS FOR CREATION OF CONJUGATED VACCINES: PROPERTIES AND APPLICATION

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Vaccination is a key element in prophylaxis of infectious diseases. Effective vaccines based on polysaccharide capsules were developed for a number of microorganisms. Effectiveness of polysaccharides as antigens, however, is low in the main risk groups -
L. A. Lisitskaya, A. V. Kolesnikov, A. V. Kozyr, I. G. Shemyakin, A. K. Ryabko, O. N. Krasavtseva, LA. .. Dyatlov   +6 more
doaj   +1 more source

Prospects for ion chromatography in quality assessment of biologicals

Биопрепараты: Профилактика, диагностика, лечение, 2022
Quantitative characterisation of excipients in biologicals is an important part of the quality assurance process both at the level of finished products and intermediates, as well as active pharmaceutical ingredients.
A. S. Minero, O. B. Runova, O. B. Ustinnikova, A. A. Movsesyants   +3 more
doaj   +1 more source

SEROTYPE-INDEPENDENT VACCINES AGAINST PNEUMOCOCCAL INFECTION

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Creation of serotype-independent vaccines includes 4 directions - construction of protein vaccines based on recombinant pneumococcus proteins, whole-cell killed or attenuated vaccines, DNA-vaccines and use of Streptococcus pneumoniae as a carrier for ...
I. B. Semenova, N. A. Mikhailova
doaj   +1 more source

A universal UHPLC-CAD platform for the quantification of polysaccharide antigens

Scientific Reports, 2023
Several glycoconjugate-based vaccines against bacterial infections have been developed and licensed for human use. Polysaccharide (PS) analysis and characterization is therefore critical to profile the composition of polysaccharide-based vaccines. For PS
A. Corrado, M. De Martino, V. Bordoni, S. Giannini, F. Rech, S. Cianetti, F. Berti, C. Magagnoli, R. De Ricco   +8 more
doaj   +1 more source

Carrier Proteins Facilitate the Generation of Antipolysaccharide Immunity via Multiple Mechanisms

mBio, 2022
Capsular polysaccharides (CPSs) are important antigenic targets against bacterial infections. As T-independent antigens, however, CPSs elicit short-lived immune responses in adults and are poorly immunogenic in young children.
Fan Zhang, Claudette Thompson, Nicole Ma, Ying-Jie Lu, Richard Malley   +4 more
doaj   +1 more source

THE ROLE OF PROTEINS OF STREPTOCOCCUS PNEUMONIAE IN THE DEVELOPMENT OF SEROTYPE-INDEPENDENT PNEUMOCOCCAL VACCINES

Журнал микробиологии, эпидемиологии и иммунобиологии, 2019
Infections caused by Streptococcus pneumoniae are relevant for Russia and the world. One of the key factors in the pathogenicity of pneumococcus is a polysaccharide capsule.
E. S. Petukhova, D. S. Vorobyev, I. B. Semenova   +2 more
doaj   +1 more source

Bacterial Vaccine Antigen Discovery in the Reverse Vaccinology 2.0 Era: Progress and Challenges

Frontiers in Immunology, 2018
The ongoing, and very serious, threat from antimicrobial resistance necessitates the development and use of preventative measures, predominantly vaccination.
Fadil A. Bidmos, Sara Siris, Camilla A. Gladstone, Paul R. Langford   +3 more
doaj   +1 more source

Safety, immunogenicity and dose ranging of a new Vi-CRM₁₉₇ conjugate vaccine against typhoid fever: randomized clinical testing in healthy adults. [PDF]

PLoS ONE, 2011
Typhoid fever causes more than 21 million cases of disease and 200,000 deaths yearly worldwide, with more than 90% of the disease burden being reported from Asia.
Pierre van Damme, Froukje Kafeja, Alessandra Anemona, Venere Basile, Anne Katrin Hilbert, Ilse De Coster, Simona Rondini, Francesca Micoli, Rana M Qasim Khan, Elisa Marchetti, Vito Di Cioccio, Allan Saul, Laura B Martin, Audino Podda   +13 more
doaj   +1 more source

Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants. [PDF]

, 2010
BACKGROUND: Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are persistent herpesviruses that have various immunomodulatory effects on their hosts. Both viruses are usually acquired in infancy in Sub-Saharan Africa, a region where childhood vaccines ...
Ebrima S Touray, Whittle, H., Miles David J. C., Kaye, Steve, Melba S Palmero, Roberts, E., Ojuola, Olubukola, Miles, DJ, Palmero Melba S., Ojuola, O, Kaye Steve, Duah, NO, Mohammed, N.I., Cotten, M., Marianne van der Sande, Waight Pauline, Rowland-Jones, S., van der Sande, M, Cotten, M, Touay, Ebrima S., Holder, B., Cotten Matthew, Mohammed, NI, van der Sande Marianne, Whittle, H, Crozier, Sarah, Roberts, Elishia, Rowland-Jones, Sarah, Crozier, S., Miles, David J.C., Palmero, Melba S., Ojuola Olubukola, Waight, P., Touray, ES, Beth Holder, Roberts Elishia, Nuredin Ibrahim Mohammed, Nancy O Duah, Sarah Crozier, Touray, E.S., Hilton Whittle, Mohammed, Nuredin Ibrahim, Elishia Roberts, Sarah Rowland-Jones, Ebrima S. Touray, Touray, Ebrima S, van der Sande, M., Nancy O. Duah, Matthew Cotten, Whittle Hilton, Miles, David J C, Steve Kaye, Miles, David JC, van der Sande, Marianne, Kaye, S, Ojuola, O., David J C Miles, Mohammed Nuredin Ibrahim, Holder Beth, Palmero, M.S., Duah Nancy O., Melba S. Palmero, Cotten, Matthew, Duah, Nancy O, Palmero, Melba S, Whittle, Hilton, Miles, DJC, Rowland-Jones Sarah, Miles, D.J., Kaye, S., Holder, B, Olubukola Ojuola, David J. C. Miles, Touray Ebrima S., Duah, Nancy O., Palmero, MS, Duah, N.O., Waight, Pauline, Roberts, E, Rowland-Jones, S, Holder, Beth, Waight, P, Crozier, S, Pauline Waight, Crozier Sarah   +84 more
core   +1 more source