Campylobacter Polysaccharide Capsules: Virulence and Vaccines [PDF]
Frontiers in Cellular and Infection Microbiology, 2012 Campylobacter jejuni remains a major cause of bacterial diarrhea worldwide and is associated with numerous sequelae, including Guillain Barre Syndrome, inflammatory bowel disease, reactive arthritis, and irritable bowel syndrome. C.
Patricia Guerry +2 more
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Efficacy of Pam3CSK4 as a cross-species adjuvant for polysaccharide vaccines in humanized mouse and non-human primate models [PDF]
Nature CommunicationsPolysaccharide-based vaccines are essential for preventing bacterial infections, but their effectiveness is limited by weak antibody responses and lack of suitable adjuvants. TLR4 agonists enhance polysaccharide-specific antibody responses through B cell–
Jamie E. Jennings-Gee +2 more
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mGem: Progress on the development of conjugate vaccines for Cryptococcus neoformans infections [PDF]
mBioCryptococcus neoformans is an important fungal pathogen that causes cryptococcosis, a life-threatening disease predominantly affecting immunocompromised individuals.
Piotr R. Stempinski +2 more
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Recombinant plants provide a new approach to the production of bacterial polysaccharide for vaccines. [PDF]
PLoS ONE, 2014 Bacterial polysaccharides have numerous clinical or industrial uses. Recombinant plants could offer the possibility of producing bacterial polysaccharides on a large scale and free of contaminating bacterial toxins and antigens.
Claire M Smith +8 more
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Future Pneumococcal Vaccines: Shifting from Capsular Polysaccharides to Protein-Based Immunogens [PDF]
VaccinesStreptococcus pneumoniae (S. pneumoniae) is a leading cause of pneumonia, meningitis, and sepsis worldwide, posing a major threat to young children and older adults.
Ruodan Zheng +6 more
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Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines [PDF]
Molecules, 2018 Francesco Berti +2 more
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Triptych of the Hermit Saints: pneumococcal polysaccharide vaccines for the elderly. [PDF]
Risk Manag Healthc Policy, 2018 Ger T Rijkers,1,2 Laura IE Yousif,1 Simone MC Spoorenberg,3 Frans J van Overveld1 1Department of Science, University College Roosevelt, Middelburg, the Netherlands; 2Department of Medical Microbiology and Immunology, St. Antonius Hospital ...
Rijkers GT +3 more
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Carrier-Protein-Free Pneumococcal Glycoconjugate Vaccines Enabled by SPAAC: Serotype 15C CPS–PADRE Conjugates and the Impact of an RR Cleavage Motif [PDF]
VaccinesBackground/Objectives: Polysaccharide-protein conjugate vaccines have proven highly effective, yet they remain limited by manufacturing complexity, cost, and variable performance across serotypes, while carrier proteins can add unwanted immunological and
Huimin Yang +5 more
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Биопрепараты: Профилактика, диагностика, лечение, 2018 Despite the progress in fighting against infectious diseases of bacterial origin, the incidence of generalized forms of meningococcal infection (GFMI) remains a topical public health problem not only in countries with historical high incidence, but also ...
M. V. Abramtseva +2 more
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Conjugation Mechanism for Pneumococcal Glycoconjugate Vaccines: Classic and Emerging Methods
Bioengineering, 2022 Licensed glycoconjugate vaccines are generally prepared using native or sized polysaccharides coupled to a carrier protein through random linkages along the polysaccharide chain.
Victor Morais, Norma Suarez
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