Results 51 to 60 of about 756,756 (215)
Advances in Cytosolic Delivery of Proteins: Approaches, Challenges, and Emerging Technologies
Chemistry &Biodiversity, EarlyView.Proteins regulate almost all biological processes, and overcoming the protein's natural membrane inpermeability will provide a unique opportunity for intracellular targeting of related therapeutic proteins. Chemical modification of proteins and different types of delivery vectors can mediate intracellular transport of proteins, providing new ideas for ...
Wenyan Zhang +8 more
wiley +1 more source
Quantification of sulfated polysaccharides in urine by the Heparin Red mix-and-read fluorescence assay [PDF]
arXiv, 2018 Quantification of sulfated polysaccharides in urine samples is relevant to pharmacokinetic studies in drug development projects and to the non-invasive diagnosis and therapy monitoring of mucopolysaccharidoses. The Heparin Red Kit is a particularly simple and user friendly fluorescence assay for the quantification of sulfated polysaccharides and has ...
arxiv
Chemistry &Biodiversity, Accepted Article.Objective: Cancer remains a global health challenge, necessitating new therapeutic options. Phytochemicals, with diverse chemical structures and biological activities, show promise as anticancer agents. This review explores key phytochemicals, their mechanisms, and their potential integration into cancer therapy.
Alaa A. A. Aljabali +11 more
wiley +1 more source
Vaccination dilemma on an evolving social network [PDF]
arXiv, 2019 Vaccination is crucial for the control of epidemics. Yet it is a social dilemma since non-vaccinators can benefit from the herd immunity created by the vaccinators. Thus the optimum vaccination level is not reached via voluntary vaccination at times.
arxiv
Promising Prodiginins Biological Activities
Chemistry &Biodiversity, EarlyView.ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto +6 more
wiley +1 more source
Detecting Anti-Vaccine Users on Twitter [PDF]
arXiv, 2021 Vaccine hesitancy, which has recently been driven by online narratives, significantly degrades the efficacy of vaccination strategies, such as those for COVID-19. Despite broad agreement in the medical community about the safety and efficacy of available vaccines, a large number of social media users continue to be inundated with false information ...
arxiv
Bioactives From Brown Algae: Antioxidant, Anti‐Inflammatory, Anticancer, and Antimicrobial Potential
ChemBioEng Reviews, EarlyView.This review explores key bioactives in brown algae and their antioxidant, anti‐inflammatory, anticancer, and antimicrobial properties. Covering studies from 2014 to 2024, it highlights their relevance in pharmaceuticals, nutraceuticals, cosmetics, and foods, while addressing challenges and future directions to unlock their full potential.
Irvin Fonseca‐Barahona +2 more
wiley +1 more source
Quantification of sulfated polysaccharides in mouse and rat plasma by the Heparin Red mix-and-read fluorescence assay [PDF]
arXiv, 2017 Sulfated polysaccharides constitute a large and complex group of macromolecules which possess a wide range of important biological properties. Many of them hold promise as new therapeutics, but determination of their blood levels during pharmacokinetic studies can be challenging.
arxiv
Reviewing Glycosyl‐Inositols: Natural Occurrence, Biological Roles, and Synthetic Techniques
ChemBioChem, Volume 26, Issue 6, March 15, 2025.Overall, this comprehensive review underscores the significance of glycosyl inositols as versatile molecules with diverse biological functions and promising applications in scientific research and industry. Methods for their chemical and enzymatic synthesis are also reviewed, highlighting recent advances and challenges in the field.
Alfonso Miranda‐Molina +3 more
wiley +1 more source
ChemBioChem, EarlyView.This analysis reveals structural heterogeneity in the lipopolysaccharide lipid A from the cold‐adapted Gram‐negative bacterium Polaribacter sp. SM1127, with variations in fatty acid chain number, length, branching, saturation, and hydroxylation degree, likely aiding bacterial adaptation to cold environmental stressors. Lipopolysaccharide is shown to be
Roberta Cirella +9 more
wiley +1 more source