Results 91 to 100 of about 320,389 (303)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Gayana, 2012 La zona central de Chile se caracteriza por ser un ambiente de tipo mediterráneo con marcada estacionalidad climática. En esta zona de gran actividad agrícola existen tranques artificiales destinados al regadío, los cuales pueden generar ambientes que ...
Isaac Peña-Villalobos +3 more
doaj
Water Quality Characteristics of Some Ponds in Van (Türkiye) Province
Çanakkale Onsekiz Mart University Journal of Marine Sciences and FisheriesThis study was conducted to investigate the physical and chemical properties of the waters of Lower Tulgalı, Oymaklı, Sırımlı, Morçiçek and Sağmalı ponds in Van province during the Autumn (November 2022), Spring (May 2023) and Summer (July 2023) seasons.
Muhammet Demir
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Revue Archéologique du Centre de la France, 2013 For the last 25 years, the new development of Marne-la-Vallée, that includes the town of Bussy-Saint-Georges, has been under extensive archaeological investigation. The latest sectors to be surveyed to the East have revealed a network of moats, organized
Johann Blanchard
doaj
Traffic State Estimation With Spatio-Temporal Autoencoding Transformer (STAT Model)
IEEE AccessTraffic state estimation is an essential component of Intelligent Transportation System (ITS) designed for alleviating traffic congestion. As traffic data is composed of intricate information which can also be impacted by various factors, scholars have ...
Ali Reza Sattarzadeh +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Design of sediment oxygen demand (SOD) 'in-situ' measuring chamber and its application in several rivers [PDF]
, 2001 Sediment oxygen demand is defined as the rate of dissolved oxygen removal from the water column by the decomposition of organic materials in the bottom sediments.
Mohamed, Maketab, Yusop, Zulkifli
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source